Oliver Distler
A5059359523- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Mast cells and histamine
- Connective Tissue Growth Factor Research
- Pulmonary Hypertension Research and Treatments
- Autoimmune Bullous Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Eosinophilic Disorders and Syndromes
- Medical Imaging and Pathology Studies
- Systemic Lupus Erythematosus Research
- Dermatological and Skeletal Disorders
- Skin Diseases and Diabetes
- Cancer Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Fibroblast Growth Factor Research
- SARS-CoV-2 and COVID-19 Research
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Spondyloarthritis Studies and Treatments
- Urticaria and Related Conditions
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
University of Zurich
2015-2025
University Hospital of Zurich
2016-2025
Universitätsklinik Balgrist
2020-2024
Center for Rheumatology
2009-2023
University of California, San Francisco
2023
University of Lausanne
2023
University of Florence
2004-2022
University of Birmingham
2021-2022
University of Trieste
2022
Università Cattolica del Sacro Cuore
2022
Objective The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new Methods Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested 1) determining...
<h3>Objective</h3> The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new <h3>Methods</h3> Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested...
Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis and leading cause sclerosis–related death. Nintedanib, tyrosine kinase inhibitor, has been shown to have antifibrotic antiinflammatory effects in preclinical models ILD.
<h3>Objective</h3> Earlier detection of pulmonary arterial hypertension (PAH), a leading cause death in systemic sclerosis (SSc), facilitates earlier treatment. The objective this study was to develop the first evidence-based algorithm for PAH SSc. <h3>Methods</h3> In cross-sectional, international conducted 62 experienced centres from North America, Europe and Asia, adults with SSc at increased risk (SSc >3 years predicted diffusing capacity carbon monoxide <60%) underwent broad panel...
The transforming growth factor-β (TGF-β) signalling pathway is a key mediator of fibroblast activation that drives the aberrant synthesis extracellular matrix in fibrotic diseases. Here we demonstrate novel link between and canonical Wnt pathway. TGF-β stimulates p38-dependent manner by decreasing expression antagonist Dickkopf-1. Tissue samples from human diseases show enhanced proteins decreased Activation fibroblasts vitro induces fibrosis vivo. Transgenic overexpression Dickkopf-1...
The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with arterial (PAH). Low-, intermediate- and high-risk strata are defined by estimated 1-year mortality risks of <5%, 5–10% >10%, respectively. This assessment awaits validation. We analysed data from newly diagnosed PAH enrolled into COMPERA (Comparative, Prospective Registry Newly Initiated Therapies Pulmonary Hypertension), European-based PH registry. An abbreviated version...
Background— Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis and increased cardiovascular morbidity mortality. Striking similarities exist in the inflammatory immunologic response RA atherosclerosis. Indeed, adhesion molecules cytokines, tumor necrosis factor (TNF)-α particular, are key mediators of joint inflammation vascular dysfunction progression atherosclerotic disease. Hence, aim present study was to assess effect chronic antiinflammatory treatment anti-TNF-α...
Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 2011, we examined certificates all French patients with SSc to death. Then developed a score associated all-cause mortality from international European Scleroderma Trials Research (EUSTAR) database. Candidate prognostic were tested by Cox proportional hazards regression model single variable analysis, followed multiple stratified centres. The bootstrapping technique was used for...
To investigate the role of microRNA (miRNA) as posttranscriptional regulators profibrotic genes in systemic sclerosis (SSc).MicroRNA, which target collagens, were identified by silico analysis. Expression miRNA-29 (miR-29) was determined TaqMan real-time polymerase chain reaction analysis skin biopsy and fibroblast samples from SSc patients healthy controls well mouse model bleomycin-induced fibrosis. Cells transfected with precursor miRNA (pre-miRNA)/anti-miRNA miR-29 using Lipofectamine....
The modified Rodnan skin score (mRSS) is a measure of thickness and used as primary or secondary outcome in clinical trials systemic sclerosis (scleroderma). This state-of-art review provides historical perspective the development mRSS, summarizes performance mRSS an measure, guidance on assessing makes recommendations for incorporation into trials.
Objectives To assess the effects of Rituximab (RTX) on skin and lung fibrosis in patients with systemic sclerosis (SSc) belonging to European Scleroderma Trial Research (EUSTAR) cohort using a nested case-control design. Methods Inclusion criteria were fulfilment American College Rheumatology classification for SSc, treatment RTX availability follow-up data. RTX-treated matched control from EUSTAR database not treated RTX. Matching parameters skin/lung modified Rodnan Skin Score (mRSS),...
Objective To identify a core set of preliminary items considered as important for the very early diagnosis systemic sclerosis (SSc). Methods A list provided by European League Against Rheumatism (EULAR) Scleroderma Trial and Research(EUSTAR) centres were subjected to Delphi exercise among 110 experts in field SSc. In round 1, asked choose they most 2, reconsider accepted after first stage. 3, clinical relevance selected their importance measures that would lead an referral process rated...
Imatinib mesylate is a clinically well-tolerated small molecule inhibitor that exerts selective, dual inhibition of the transforming growth factor beta (TGFbeta) and platelet-derived (PDGF) pathways. This study was undertaken to test potential use imatinib as an antifibrotic drug for treatment dermal fibrosis in systemic sclerosis (SSc).The expression extracellular matrix (ECM) proteins SSc normal fibroblasts analyzed by real-time polymerase chain reaction, Western blot, Sircol collagen...
<h3>Objectives</h3> Systemic sclerosis (SSc) is a rare disease requiring multicentre collaboration to reveal comprehensive details of disease-related causes for morbidity and mortality. <h3>Methods</h3> The European League Against Rheumatism (EULAR) Scleroderma Trials Research (EUSTAR) group initiated database prospectively gather key data patients with SSc using minimal essential dataset that was reorganised in 2008 introducing new items. Baseline visit who were registered between 2004 2011...
Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various kinases, several which have been implicated in aberrant fibroblast activation fibrotic diseases including systemic sclerosis (SSc). Here we show that profibrotic signals converge on STAT3 may be an important molecular checkpoint for tissue fibrosis. signaling hyperactivated SSc a TGFβ-dependent manner. Expression profiling functional studies vitro vivo demonstrate mediated the combined action JAK, SRC,...
To identify overall disease course, progression patterns and risk factors predictive for progressive interstitial lung (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials And Research (EUSTAR) database over long-term follow-up.
<h3>Objectives</h3> Autophagy is a homeostatic process to recycle dispensable and damaged cell organelles. Dysregulation of autophagic pathways has recently been implicated in the pathogenesis various diseases. Here, we investigated role autophagy during joint destruction arthritis. <h3>Methods</h3> osteoclasts was analysed vitro ex vivo by transmission electron microscopy, Western blotting immunohistochemistry for Beclin1 Atg7. Small molecule inhibitors, LysMCre-mediated knockout Atg7...