Gabriele Valentini
A5105230322- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Dermatologic Treatments and Research
- Rheumatoid Arthritis Research and Therapies
- Mast cells and histamine
- Pulmonary Hypertension Research and Treatments
- Connective Tissue Growth Factor Research
- Autoimmune Bullous Skin Diseases
- Skin Diseases and Diabetes
- Eosinophilic Disorders and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Diagnosis and Treatment of Venous Diseases
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging and Pathology Studies
- Urticaria and Related Conditions
- Autoimmune and Inflammatory Disorders Research
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Dermatological and Skeletal Disorders
- Celiac Disease Research and Management
- Hepatitis C virus research
- Chronic Lymphocytic Leukemia Research
- Inflammatory Bowel Disease
Azienda Ospedaliera Santa Maria Degli Angeli
2025
University of Campania "Luigi Vanvitelli"
2013-2022
Regione Campania
2021
University of Naples Federico II
2011-2020
Policlinico Universitario di Catania
2013-2019
Ospedale Monaldi
2010-2019
Magna Graecia University
2018
University of Bari Aldo Moro
2018
University of Palermo
2018
University of L'Aquila
2018
Objective The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new Methods Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested 1) determining...
<h3>Objective</h3> The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new <h3>Methods</h3> Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested...
<h3>Objectives</h3> To determine the causes and predictors of mortality in systemic sclerosis (SSc). <h3>Methods</h3> Patients with SSc (n=5860) fulfilling American College Rheumatology criteria prospectively followed EULAR Scleroderma Trials Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause death comorbidities. Kaplan–Meier Cox proportional hazards models used to analyse survival subgroups identify mortality. <h3>Results</h3> Questionnaires...
Purpose: The optimal treatment of systemic sclerosis (SSc) is a challenge because the pathogenesis SSc unclear and it an uncommon clinically heterogeneous disease affecting multiple organ systems. aim European League Against Rheumatism (EULAR) Scleroderma Trials Research group (EUSTAR) was to develop evidence-based, consensus-derived recommendations for SSc. Methods: To obtain maintain high level intrinsic quality comparability this approach, EULAR standard operating procedures were...
<h3>Objectives:</h3> To develop evidence-based recommendations for the use of methotrexate in daily clinical practice rheumatic disorders. <h3>Methods:</h3> 751 rheumatologists from 17 countries participated 3E (Evidence, Expertise, Exchange) Initiative 2007–8 consisting three separate rounds discussions and Delphi votes. Ten questions concerning disorders were formulated. A systematic literature search Medline, Embase, Cochrane Library 2005–7 American College Rheumatology/European League...
Objectives To assess the effects of Rituximab (RTX) on skin and lung fibrosis in patients with systemic sclerosis (SSc) belonging to European Scleroderma Trial Research (EUSTAR) cohort using a nested case-control design. Methods Inclusion criteria were fulfilment American College Rheumatology classification for SSc, treatment RTX availability follow-up data. RTX-treated matched control from EUSTAR database not treated RTX. Matching parameters skin/lung modified Rodnan Skin Score (mRSS),...
Objective To identify a core set of preliminary items considered as important for the very early diagnosis systemic sclerosis (SSc). Methods A list provided by European League Against Rheumatism (EULAR) Scleroderma Trial and Research(EUSTAR) centres were subjected to Delphi exercise among 110 experts in field SSc. In round 1, asked choose they most 2, reconsider accepted after first stage. 3, clinical relevance selected their importance measures that would lead an referral process rated...
<h3>Objectives</h3> Systemic sclerosis (SSc) is a rare disease requiring multicentre collaboration to reveal comprehensive details of disease-related causes for morbidity and mortality. <h3>Methods</h3> The European League Against Rheumatism (EULAR) Scleroderma Trials Research (EUSTAR) group initiated database prospectively gather key data patients with SSc using minimal essential dataset that was reorganised in 2008 introducing new items. Baseline visit who were registered between 2004 2011...
Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating life-threatening rheumatic disease, with largely unknown pathogenesis. We have designed two-stage genome-wide association study of using case-control samples from France, Italy, Germany, Northern Europe. The initial scan was conducted in French post quality-control sample 564 cases 1,776 controls, almost 500 K SNPs. Two SNPs MHC...
Validity of European Scleroderma Study Group (EScSG) activity indexes currently used to assess disease in systemic sclerosis (SSc) has been criticised.Three investigators assigned an score on a 0-10 scale for 97 clinical charts. The median served as gold standard. Two other labelled the inactive/moderately active or active/very active. Univariate-multivariate linear regression analyses were define variables predicting 'gold standard', their weight and derive index. cut-off point index best...
To develop criteria for disease activity in systemic sclerosis (SSc) that are valid, reliable, and easy to use.Investigators from 19 European centres completed a standardised clinical chart consecutive number of patients with SSc. Three protocol management members blindly evaluated each assigned score on semiquantitative scale 0-10. Two them, addition, gave blinded, qualitative evaluation ("inactive moderately active" or "active very disease). Both these evaluations were found be reliable. A...
Abstract Objective The Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes (TEMPO) is a 3‐year, double‐blind, multicenter study evaluating the efficacy safety etanercept, methotrexate, combination etanercept plus methotrexate in patients active rheumatoid arthritis (RA). results after 1 2 years have been previously reported. Here we provide 3‐year clinical radiographic outcomes RA. Methods In this randomized, TEMPO study, 682 received 25 mg twice weekly, ≤20 or...
To examine the role of sex steroid hormones in development autoimmune diseases, we studied five patients with Klinefelter's syndrome associated disease, three whom had Sjögren's (SS) and two systemic lupus erythematosus (SLE). Serum testosterone (T) LH levels, antinuclear antibodies (ANA) rheumatoid factor (RF) titers, erythrocyte sedimentation rate (ESR), hemolytic complement (CH50) peripheral T lymphocyte subsets (OKT3+, OKT4+, OKT8+) were measured before treatment, after 60 days placebo...
Early diagnosis of systemic sclerosis (SSc) may allow the start treatment that could slow disease progression. For this reason early is pivotal importance. However, lack diagnostic criteria and valid predictors significantly limit patient evaluation use potentially effective drugs in earliest phase SSc. SSc be suspected on basis Raynaud's phenomenon, puffy fingers, autoantibodies capillaroscopic pattern. In practice, aim to have for very The are proposed obviously provisional need validated:...
Adult-onset Still’s disease (AOSD) is rare inflammatory of unknown etiology that usually affects young adults. The more common clinical manifestations are spiking fevers, arthritis, evanescent rash, elevated liver enzymes, lymphadenopathy, hepatosplenomegaly, and serositis. multi-visceral involvement the different complications, such as macrophage activation syndrome, may strongly decrease life expectancy AOSD patients. This study aimed to identify positive negative features correlated with...
To assess fetal and maternal outcomes in women with systemic sclerosis (SSc).Prospectively collected data on 99 SSc from 25 Italian centers were analyzed retrospectively. Women observed during 109 pregnancies (from 2000 to 2011), compared those the general obstetric population (total of 3,939 deliveries). The age at conception was a mean ± SD 31.8 5.3 years, median disease duration 60 months (range 2-193 months).SSc patients, population, had significantly increased frequency preterm...
Objective Systemic sclerosis (SSc) is associated with a significant reduction in life expectancy. A simple prognostic model to predict 5-year survival SSc was developed 1999 280 patients, but it has not been validated other patients. The predictions of are usually less accurate especially from centres or countries. study undertaken validate the throughout Europe. Methods European multicentre cohort patients diagnosed before 2002 established. Patients according preliminary American College...