Franco Cozzi
A5102819818- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Mast cells and histamine
- Pulmonary Hypertension Research and Treatments
- Therapeutic Uses of Natural Elements
- Skin Diseases and Diabetes
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Eosinophilic Disorders and Syndromes
- Autoimmune Bullous Skin Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Peripheral Neuropathies and Disorders
- Diagnosis and Treatment of Venous Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vasculitis and related conditions
- Dermatological and COVID-19 studies
- Neonatal Health and Biochemistry
- Autoimmune and Inflammatory Disorders Research
- Dermatological and Skeletal Disorders
- Cardiovascular Function and Risk Factors
- Immunodeficiency and Autoimmune Disorders
University of Padua
2013-2022
University of Siena
2021
Ellis Hospital
2021
Inoue Hospital
2015-2019
Blackpool Teaching Hospitals NHS Foundation Trust
2018
Center for Rheumatology
2001-2016
March of Dimes
2015
Policlinico Universitario di Catania
2011
Loyola University Chicago
2009
University of Chicago
2009
<h3>Objectives</h3> To determine the causes and predictors of mortality in systemic sclerosis (SSc). <h3>Methods</h3> Patients with SSc (n=5860) fulfilling American College Rheumatology criteria prospectively followed EULAR Scleroderma Trials Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause death comorbidities. Kaplan–Meier Cox proportional hazards models used to analyse survival subgroups identify mortality. <h3>Results</h3> Questionnaires...
Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 2011, we examined certificates all French patients with SSc to death. Then developed a score associated all-cause mortality from international European Scleroderma Trials Research (EUSTAR) database. Candidate prognostic were tested by Cox proportional hazards regression model single variable analysis, followed multiple stratified centres. The bootstrapping technique was used for...
To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc).The EUSTAR database was first searched. A case-control study of a patient subset then performed to further identify independent with LV by simple multiple regression.Of 7073 patients, 383 (5.4%) had an ejection fraction (EF) <55%. By regression analysis, age, sex, diffuse cutaneous disease, disease duration, digital ulcerations, renal muscle involvement, activity score,...
Abstract Objective To develop criteria for the classification of systemic sclerosis (SSc) in children (juvenile SSc). Methods The study consisted 3 phases: 1) collection data on signs and symptoms actual patients with juvenile SSc that are useful defining involvement a particular organ; 2) selection parameters essential preparation set provisional (PCC) using 2 Delphi surveys; 3) consensus conference consisting steps: discussion rating clinical profiles 160 definite SSc, possible or other...
To assess fetal and maternal outcomes in women with systemic sclerosis (SSc).Prospectively collected data on 99 SSc from 25 Italian centers were analyzed retrospectively. Women observed during 109 pregnancies (from 2000 to 2011), compared those the general obstetric population (total of 3,939 deliveries). The age at conception was a mean ± SD 31.8 5.3 years, median disease duration 60 months (range 2-193 months).SSc patients, population, had significantly increased frequency preterm...
Objective Systemic sclerosis (SSc) is a systemic autoimmune disease with high morbidity and significant mortality. There great need of predictors that would allow risk stratification patients SSc ultimately initiation treatment early enough to ensure optimal clinical results. In this study, we evaluated whether history digital ulcers (HDU) at presentation may be predictor vascular outcomes overall worsening death in SSc. Methods Patients from the EULAR Scleroderma Trials Research (EUSTAR)...
Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that typically subdivided into limited cutaneous SSc (lcSSc) and diffuse (dcSSc) depending on the extent of skin involvement. This subclassification may not capture entire variability clinical phenotypes. The European Scleroderma Trials Research (EUSTAR) database includes data prospective cohort patients from 122 referral centers. study was undertaken to perform cluster analysis EUSTAR distinguish characterize homogeneous...
In agreement with other autoimmune diseases, systemic sclerosis (SSc) is associated a strong sex bias. However, unlike lupus, the effects of on disease phenotype and prognosis are poorly known. Therefore, we aimed to determine outcomes.We performed prospective observational study using latest 2013 data extract from EULAR scleroderma trials research (EUSTAR) cohort. We looked at (i) influence characteristics baseline (ii) then focused patients least 2 years follow-up estimate progression...
The multisystem manifestations of SSc can greatly impact patients' quality life. aim this study was to identify factors associated with disability in SSc. patients from the prospective DeSScipher cohort who had completed scleroderma health assessment questionnaire (SHAQ), a score that combines and five visual analogue scales, were included analysis. effect possibly analysed multiple linear regressions. mean SHAQ HAQ scores 944 0.87 (s.d. = 0.66) 0.92 0.78); 59% mild moderate difficulty...
Abstract Objective Previous studies have revealed the presence of IgG antifibroblast antibodies (AFAs) capable binding to surface fibroblasts in systemic sclerosis (SSc) sera. Since chemokines may directly or indirectly affect development fibrosis, this study was undertaken investigate production induced by AFAs fibroblasts, and characterize signaling pathways molecules involved. Methods AFA‐positive AFA‐negative were tested on fibroblasts. Chemokine messenger RNA expression screened...
Despite the efficacy of angiotensin-converting enzyme (ACE) inhibitors, prognosis patients with Scleroderma renal crisis (SRC) is characterized by a high rate mortality and progression into end-stage disease (ESRD). Our aim was to evaluate SRC in our cohort scleroderma patients. We reviewed clinical charts all who developed from 1980 2005. Outcome measures were ESRD, patients' survival SRC-related mortality. ESRD defined as need for chronic dialysis; calculated time occurrence Kaplan–Meier...
Abstract Objectives Racial factors play a significant role in SSc. We evaluated differences SSc presentations between white patients (WP), Asian (AP) and black (BP) analysed the effects of geographical locations. Methods characteristics from EUSTAR cohort were cross-sectionally compared across racial groups using survival multiple logistic regression analyses. Results The study included 9162 WP, 341 AP 181 BP. developed first non-RP feature faster than WP but slower less frequently...
To characterize patients with positive anti-topoisomerase I (ATA) in lcSSc.SSc enrolled the EUSTAR cohort a disease duration of ≤3 years at database entry were considered. We assessed risk major organ involvement following groups: ATA-lcSSc vs ACA-lcSSc and ANA without specificity (ANA)-lcSSc, ATA-dcSSc. Cox regression models time-dependent covariates performed outcomes: new-onset interstitial lung (ILD), ILD progression [forced vital capacity (FVC) decline ≥10% ≥5% values diagnosis),...
Pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF) has been poorly studied in patients systemic sclerosis (SSc). We sought compare clinical characteristics and survival of SSc PH-HFpEF (SSc-PH-HFpEF) versus pulmonary arterial (SSc-PAH). hypothesized that SSc-PH-HFpEF have a similar poor overall prognosis compared SSc-PAH when matched for total right ventricular load. The analysis included 117 SSc-PH (93 24 SSc-PH-HFpEF) enrolled prospectively the Johns...