A5050836527- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Inflammatory Myopathies and Dermatomyositis
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Vasculitis and related conditions
- Dermatologic Treatments and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Tumors Diagnosis and Treatment
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Pulmonary Hypertension Research and Treatments
- Nonlinear Optical Materials Research
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Mast cells and histamine
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Oral Health Pathology and Treatment
- Diabetes and associated disorders
- Solid-state spectroscopy and crystallography
- Liver Diseases and Immunity
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
National Clinical Research Center for Digestive Diseases
2021-2025
Academy of Medical Sciences
2014-2025
Ministry of Education of the People's Republic of China
2013-2025
National Clinical Research
2020-2025
University of Missouri
2025
Central Hospital of Zibo
2024
Capital Medical University
2009-2024
University of Toronto
2024
Abstract Objective To assess the overexpression of B lymphocyte stimulator (BLyS) over time in patients with systemic lupus erythematosus (SLE). Methods Sixty‐eight SLE were followed up longitudinally for a median 369 days. At each physician encounter, disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index, and blood collected determination serum BLyS level, messenger RNA (mRNA) cell surface expression. Twenty normal control subjects underwent similar laboratory...
Abstract Objective To determine whether synovial fluid (SF) levels and cell‐surface expression of B lymphocyte stimulator (BLyS) protein SF APRIL are elevated in patients with inflammatory arthritis (IA). Methods Same‐day blood samples from 89 103 knee effusions (81 knees IA 22 noninflammatory [NIA]) were evaluated for BLyS by enzyme‐linked immunosorbent assay. Blood mononuclear cells double‐stained surface CD14 (monocyte marker) analyzed flow cytometry. Complete cell counts nucleated...
Abstract The biochemical response to ursodeoxycholic acid (UDCA) in primary biliary cirrhosis is a strong predictor of long-term outcome and thus facilitates the rapid identification patients needing new therapeutic approaches. Numerous criteria for predicting treatment have been studied based on UDCA at 1 year. We sought determine whether an earlier 3 or 6 months could as efficiently identify risk poor outcome, defined by liver-related death, liver transplantation, complications cirrhosis....
To characterize serum IgG subclass levels in several autoimmune diseases, including primary Sjogren syndrome (pSS), systemic sclerosis (SSc), lupus erythematosus (SLE), and biliary cirrhosis (PBC). We aimed to analyze distribution test whether IgG4 are elevated these diseases. Serum from 102 pSS, SSc, 100 SLE, 59 PBC patients, as well 40 healthy controls (HCs), were measured using the immunonephelometric assay. The of subclasses among diseases was analyzed. In this cross-sectional study,...
This phase 2b, randomised, double-blind, placebo-controlled trial evaluated the efficacy and safety of telitacicept, a novel fusion protein that neutralises signals B lymphocyte stimulator proliferation-inducing ligand, in active systemic lupus erythematosus (SLE).
Abstract Objective To evaluate the efficacy and safety of telitacicept in adult patients with primary SS (pSS) a phase II randomized double-blind placebo-controlled trial. Methods Patients pSS positive anti-SSA antibody ESSDAI ≥ 5 were randomly assigned, 1:1:1 ratio, to receive weekly subcutaneous 240 mg, 160 or placebo for 24 weeks. The end point was change from baseline at week 24. Safety monitored. Results A total 42 enrolled (n = 14 per group). Administration mg resulted significant...
Abstract Motivation: Unlike traditional diagnosis of an existing disease state, detecting the pre-disease state just before serious deterioration a is challenging task, because system may show little apparent change or symptoms this critical transition during progression. By exploring rich interaction information provided by high-throughput data, dynamical network biomarker (DNB) can identify but requires multiple samples to reach correct for one individual, thereby restricting its clinical...
The objective of this study was to evaluate the safety and efficacy allogeneic bone marrow mesenchymal stromal/stem cell transplantation (BM-MSCT) for patients with ursodeoxycholic acid (UDCA)-resistant primary biliary cirrhosis (PBC). Ten were enrolled in trial BM-MSCT. All permitted concurrently continue their previous UDCA treatment. BM-MSCT UDCA-resistant PBC assessed at various time points throughout 12-month follow up. No transplantation-related side effects observed. life quality...
To investigate the clinical features, outcome, and risk factors of disease flares in patients with pregnancy-related lupus (PRL).Medical charts 155 consecutive PRL inpatients were systematically reviewed, including demographic data, laboratory findings, treatment, complications, outcome.PRL cases divided into active (a-PRL) (n = 82, 53.0%) stable (s-PRL) 73, 47.0%). Compared nonpregnant female systemic erythematosus (SLE) patients, a-PRL new-onset (n-PRL) flare (f-PRL) 41 respectively), had...
Abstract Objective To determine whether overexpression of BAFF can accelerate the development systemic lupus erythematosus–associated end‐organ disease in hosts with an underlying autoimmune diathesis. Methods We introduced a transgene (Tg) into autoimmune‐prone B6.Sle1 and B6.Nba2 mice evaluated these for serologic autoimmunity renal pathology. Results B6.Sle1.BAFF B6.Nba2.BAFF mice, but not non‐Tg littermates, frequently developed severe glomerular pathology by 3 months age. Age‐matched...
To investigate the clinical features of Rhupus syndrome, we retrospectively reviewed medical records 56 patients with who were hospitalized at Peking Union Medical College Hospital, Beijing, China, between January 2000 and March 2013. We analyzed manifestations syndrome compared these a control group 160 randomly selected systemic lupus erythematosus (SLE) without coexisting rheumatoid arthritis (RA). In our center, 1.30% (56/4301) SLE had syndrome. The median disease duration was 8.0 years...
Abstract Objectives Racial factors play a significant role in SSc. We evaluated differences SSc presentations between white patients (WP), Asian (AP) and black (BP) analysed the effects of geographical locations. Methods characteristics from EUSTAR cohort were cross-sectionally compared across racial groups using survival multiple logistic regression analyses. Results The study included 9162 WP, 341 AP 181 BP. developed first non-RP feature faster than WP but slower less frequently...
Objectives Primary Sjögren's syndrome (pSS) is an important cause of pulmonary arterial hypertension (PAH), which remains insufficiently studied and needs attention. This study aimed to investigate the clinical characteristics, risk factors, prognosis assessment pSS-PAH. Methods We established a multicentre cohort pSS-PAH diagnosed by right heart catheterisation. The case–control was conducted with pSS-non-PAH patients as control group identify factors for PAH. In study, survival calculated,...
Background Synovial hypoxia is a hallmark of rheumatoid arthritis (RA). Photoacoustic (PA) imaging, based on the use laser-generated US, can detect oxygenation status tissue in individuals with RA. However, large studies are lacking, few investigating correlation between and disease activity. Purpose To measure synovial participants RA by using multimodal PA US imaging system to determine imaging-measured oxygen saturation (SO2) Materials Methods In this prospective observational cohort...
To characterize 414 patients with primary SS who developed haematological malignancies and to analyse how the main SS- lymphoma-related features can modify presentation patterns outcomes.By January 2021, Big Data Sjögren Project Consortium database included 11 966 fulfilling 2002/2016 classification criteria. Haematological diagnosed according World Health Organization (WHO) were retrospectively identified.There (355 women, mean age 57 years) (in 43, malignancy preceded at least one year...
Abstract Objective Early personalized identification of systemic sclerosis (SSc) patients at risk for scleroderma renal crisis (SRC) can help provide better treatment and improve outcomes. This study aimed to create validate a new multi-predictor nomogram predict SRC compare it an existing model. Methods A retrospective multicentre observational was conducted using clinical data from SSc with registered in the Chinese Rheumatism Data Center (CRDC) database. Each patient matched four without...