A5065034639- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- Autoimmune and Inflammatory Disorders Research
- Salivary Gland Disorders and Functions
- Cancer-related molecular mechanisms research
- Case Reports on Hematomas
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Inflammatory Myopathies and Dermatomyositis
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Tuberculosis Research and Epidemiology
- Biosimilars and Bioanalytical Methods
- Pharmacological Effects of Natural Compounds
- HER2/EGFR in Cancer Research
- Pelvic and Acetabular Injuries
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
Second Affiliated Hospital of Zhejiang University
2016-2025
Nanjing Agricultural University
2024
Hanyang University
2024
Nankai University
2023
First People's Hospital of Yuhang District
2021
Zhejiang University
2009-2021
Second Affiliated Hospital of Jiangxi University of TCM
2021
Shanghai Stomatological Hospital
2020
Fudan University
2020
Changhai Hospital
2008
Abstract Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels soluble scavenger receptor-A (sSR-A) are increased patients with RA correlate positively clinical immunological features the disease. This discriminatory capacity sSR-A clinically valuable complements for early stage...
Abstract Background Rheumatoid arthritis (RA) is the most common chronic autoimmune connective tissue disease. However, early RA difficult to diagnose due lack of effective biomarkers. This study aimed identify new biomarkers and mechanisms for disease progression at transcriptome level through a combination microarray bioinformatics analyses. Methods Microarray datasets synovial in or osteoarthritis (OA) were downloaded from Gene Expression Omnibus (GEO) database, differentially expressed...
In addition to the kidney, intestine is one of most important organs involved in uric acid excretion. However, mechanism urate excretion remains unclear. Therefore, relationship between soluble and gut human intestinal cells was explored. The relevant signaling molecules were then also examined. HT-29 Caco-2 cell lines stimulated with acid. Western blotting qRT-PCR used measure protein mRNA levels. Subcellular fractionation methods immunofluorescence quantify proteins different subcellular...
Efficacy of adalimumab for ankylosing spondylitis (AS) has been established Western populations but not in the Chinese population. This study is first to evaluate efficacy and safety patients with AS.Chinese adults active AS who had an inadequate response or were intolerant ≥1 non-steroidal anti-inflammatory drugs randomised 40 mg (N=229) matching placebo (N=115) subcutaneously every other week (EOW) 12 weeks, followed by a 12-week open-label EOW phase. The primary endpoint was percentage...
Abstract Objectives Anti-melanoma differentiation-associated gene 5 (MDA5) positive DM is a life-threatening disease often complicated with rapidly progressive interstitial lung (ILD). This study aimed to establish and validate clinical prediction model for 6-month all-cause mortality in Chinese patients anti-MDA5 DM-ILD. Methods We conducted retrospective observational using single-centre derivation cohort multicentre validation cohort. Hospitalized antibody ILD course ≤3 months on...
IMPORTANCE Digital health applications have been shown to be effective in the management of chronic diseases with simple treatment targets. The potential clinical value digital rheumatoid arthritis (RA) has not well studied. OBJECTIVE To investigate whether assessing patient-reported outcomes using could result disease control for patients RA. DESIGN, SETTING, AND PARTICIPANTS This is a multicenter, open-label randomized trial 22 tertiary hospitals across China. Eligible participants were...
Abstract Background This study aimed to describe the clinical characteristics and analyze poor prognostic factors in patients with anti-MDA5 dermatomyositis. Methods A total of 126 adults dermatomyositis were enrolled this retrospective study. Information on survival time, cause death, baseline was collected. Patients divided into two groups: a group non-survival group. Items significance that showed significant differences between groups screened by Kaplan–Meier Cox regression analyses...
The purpose of this study was to investigate the role macrophage polarization in pathogenesis primary Sjogren's syndrome (pSS).
BACKGROUNDMacrophage activation syndrome (MAS) is a life-threatening complication of Still's disease (SD) characterized by overt immune cell and cytokine storm. We aimed to further understand the immunologic landscape SD MAS.METHODWe profiled PBMCs from people in healthy control group patients with or without MAS using bulk RNA-Seq single-cell (scRNA-Seq). validated expanded findings mass cytometry, flow vitro studies.RESULTSBulk SD-associated revealed strong expression genes associated type...
Current diagnosis and treatment of rheumatoid arthritis (RA) is still challenging. More than one-third patients with RA could not be accurately diagnosed because lacking biomarkers. Our recent study reported that scavenger receptor-A (SR-A) a biomarker for RA, especially anticyclic citrullinated peptide antibody (anti-CCP)–negative RA. Here, we further identified the B cell autoantigenic epitopes SR-A. By large-scale multicenter including one training three validation cohorts 1954...
Objective To compare the effectiveness and safety of tofacitinib (TOF) versus calcineurin inhibitor (CNI) as initial immunosuppressive regimen for anti-melanoma differentiation-associated gene 5-positive dermatomyositis with interstitial lung disease (MDA5+DM-ILD). Methods Adult Chinese patients newly-diagnosed MDA5+DM-ILD (ILD course<3 months) from five tertiary referral centres between April 2014 January 2023 were included this retrospective cohort study. The primary endpoint was...
Abstract Objective To assess the efficacy and safety of T‐614 versus methotrexate (MTX) in patients with active rheumatoid arthritis (RA). Methods In this multicenter, double‐blind trial, 489 randomly received either 25 mg/day for first 4 weeks 50 subsequent 20 (group 1, n = 163), 24 2, or MTX 10 mg/week 15 (n 163). Clinical laboratory parameters were analyzed at baseline 4, 10, 17, weeks. Results After treatment, American College Rheumatology 20% improvement criteria response rate group 2...
Bergenin is a C-glucoside of 4-O-methyl gallic acid isolated from several medicinal plants and has multiple biological activities. The aim this study was to assess the potential usefulness bergenin in hyperuricemia. We found that reduced serum urate levels hyperuricemia mice by promoting renal gut uric excretion. treatment increased Abcg2 expression both kidneys intestine, while Slc2a9 suppressed kidney intestine. Moreover, induced ABCG2 HK-2 Caco-2 cells, as well SLC2A9 via activation...
To investigate the role and mechanism of microRNAs (miRNAs) in fibrotic processes involved pathology systemic sclerosis (SSc).R language bioinformatics methods were used to identify differential miRNAs mRNAs analyze their biological functions. Transfection experiments performed evaluate function regulatory miR-27a-3p vitro. Levels fibrosis-related genes, SPP1 cell proliferation assessed.MiR-27a-3p is reduced both SSc lung skin tissues. Overexpression significantly inhibited genes expression...
Background Dysregulation of cell death and defective clearance dying cells are closely related to the pathogenesis lupus nephritis (LN). However, contribution a recently discovered form programmed (PCD) called ferroptosis LN has not been explored in detail. The purpose this study was investigate role its associated metabolic pathways LN. Methods composite gene expression scores were calculated by averaging z-scored transformed log2 expressed genes within each PCD pathway....
Objective: The effectiveness and safety of belimumab in Chinese lupus patients with different disease activities were investigated a real-world setting. Method: Patients who received 10 mg/kg intravenously on weeks 0, 2, 4, then every 4 background standard-of-care (SoC) therapy had follow-up more than 6 months enrolled from four centers China. They stratified according to the Safety Estrogens Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) score at baseline...
Macrophage activation syndrome (MAS) is a rare complication of autoimmune inflammatory rheumatic diseases (AIIRD) characterized by progressive and life-threatening condition with features including cytokine storm hemophagocytosis. Predisposing factors are typically associated microbial infections, genetic (distinct from typical genetically related hemophagocytic lymphohistiocytosis (HLH)), inappropriate immune system overactivation. Clinical include unremitting fever, generalized rash,...
The aim of this study was to evaluate the efficacy and safety biosimilar candidate adalimumab (HS016) compared with (Humira) for treatment active ankylosing spondylitis. A multicenter, randomized, double-blind, parallel, positive control, phase III clinical trial conducted at 28 locations in China. Patients spondylitis were randomized a 2:1 ratio subcutaneously receive 40 mg either HS016 or every other week 24 weeks. primary endpoint achieve least 20% improvement (ASAS20) patients weeks...