A5100718070- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Nephrotoxicity and Medicinal Plants
- Drug-Induced Hepatotoxicity and Protection
- Dialysis and Renal Disease Management
- Sepsis Diagnosis and Treatment
- Renal and Vascular Pathologies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Microfluidic and Capillary Electrophoresis Applications
- Renal and related cancers
- Cardiac, Anesthesia and Surgical Outcomes
- MRI in cancer diagnosis
- Advancements in Transdermal Drug Delivery
- Muscle and Compartmental Disorders
- Extracellular vesicles in disease
- Electrochemical sensors and biosensors
- Cardiac Arrest and Resuscitation
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Epigenetics and DNA Methylation
- Complement system in diseases
- MicroRNA in disease regulation
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking University First Hospital
2016-2025
Peking University
2016-2025
University of Hong Kong
2025
Ministry of Education of the People's Republic of China
2017-2025
Nanjing University of Chinese Medicine
2022-2025
North Sichuan Medical University
2025
Peking University Sixth Hospital
2025
Soochow University
2024
Minzu University of China
2018-2024
Acute kidney injury (AKI) is a complex clinical disorder associated with poor outcomes. Targeted regulation of the degree inflammation has been potential strategy for AKI management. Macrophages are main effector cells inflammation. However, macrophage heterogeneity in ischemia reperfusion induced (IRI-AKI) remains unclear. Using single-cell RNA sequencing mononuclear phagocytic system murine IRI model, authors demonstrate complementary roles resident macrophages (KRMs) and monocyte-derived...
Abstract Diabetes is a prevalent chronic metabolic disease with multiple clinical manifestations and complications, it among the leading causes of death. Painless continuous monitoring interstitial glucose highly desirable for diabetes management. Here we unprecedentedly show an integrated microneedle biosensing device. The device was manufactured 3D printing process, microfabrication electroplating enzyme immobilization step. inserted into dermis layer mouse skin showed accurate sensing...
An intelligent closed-loop system that senses glucose and automatically delivers insulin can provide enhanced glycemic control for diabetes management. Here, we report the first time on development of a wearable, sensing-controlled, ultrasound-based microneedle smart Polylactic acid (PLA) hollow microneedles were fabricated by soft lithography maintain excellent mechanical strength stability in biofluids, followed deposition sensing electrodes outer layer. ultrasonic pump was constructed...
Impaired consciousness requires altered cortical function. This can occur either directly from disorders that impair widespread bilateral regions of the cortex or indirectly through effects on subcortical arousal systems. It has therefore long been puzzling why focal temporal lobe seizures so often consciousness. Early work suggested may with dominant seizure involvement. However, other do not More recent supports a 'network inhibition hypothesis' in which disrupt brainstem–diencephalic...
Cyclin G1 regulates G 2 -M arrest in proximal tubular cells, promoting a TASCC-induced secretory phenotype, fibrosis, and kidney disease progression.
Low cell retention and engraftment after transplantation limit the successful application of stem therapy for AKI. Engineered microenvironments consisting a hydrogel matrix growth factors have been increasingly in controlling fate by mimicking native niche components. Here, we synthesized bioactive immobilizing C domain peptide IGF-1 (IGF-1C) on chitosan, hypothesized that this could provide favorable adipose-derived mesenchymal cells (ADSCs) thereby enhance survival an AKI model. In vitro...
Objective More recent studies suggested that defects in autophagy contribute to the pathogenesis of SLE, especially adaptive immunity. Occurrence and progression lupus nephritis (LN) is end result complex interactions between regulation immune responses pathological process by renal resident cells, but there still a lot missing information for an establishment on role LN as therapy target. Methods Systemic organ-specific aetiologies were first evaluated protein quantification tissue...
Mitochondrial dysfunction has important roles in the pathogenesis of AKI, yet therapeutic approaches to improve mitochondrial function remain limited. In this study, we investigated pathogenic role microRNA-709 (miR-709) mediating impairment and tubular cell death AKI. a cisplatin-induced AKI mouse model biopsy samples human kidney tissue, miR-709 was significantly upregulated proximal cells (PTCs). The expression renal PTCs patients with correlated severity injury. cultured PTCs,...
Developing a miniaturized, low-cost, and smart closed-loop system for diabetes could significantly improve life quality benefit millions of people. Conventional devices are large in size exorbitant. Here, we unprecedentedly demonstrate an electrically controlled flexible patch continuous management by integrating hollow biodegradable microneedles with biosensing device electroosmotic pump. The were fabricated using combination soft lithography micromachining. outer layer the was...
Article11 January 2023Open Access Source DataTransparent process LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease Mi Bai Department of Nephrology, State Key Laboratory Reproductive Medicine, Children's Hospital Nanjing Medical University, Nanjing, China Jiangsu Pediatrics, Contribution: Data curation, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing - original draft Search for more papers by this author Mengqiu Wu...
Flexible miniature robots are expected to enter difficult-to-reach areas in vivo carry out targeted operations, attracting widespread attention. However, it is challenging for the existing soft substantially alter their stable shape once structure designed. This limitation leads a fixed motion mode, which subsequently restricts operating environment. In this study, we designed biocompatible flexible robot with variable form that capable of adapting complex terrain environments through...
Background & AimsNumerous studies have evaluated the role of human albumin (HA) in managing various liver cirrhosis-related complications. However, their conclusions remain partially controversial, probably because HA was different settings, including indications, patient characteristics, and dosage duration therapy.MethodsThirty-three investigators from 19 countries with expertise complications were invited to organize an International Special Interest Group. A three-round Delphi consensus...
The roles of nuclear receptor subfamily 1 group d member (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that genes, especially NR1D1, were dysregulated mice with carbon tetrachloride (CCl4)-induced fibrosis. In turn, disruption exacerbated experimental NR1D1-deficient more sensitive to CCl4-induced fibrosis, supporting a critical role NR1D1 development. Validation at tissue cellular levels was primarily degraded by N6-methyladenosine (m6A) methylation...
Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no model targeting among general hospitalized patients in developing countries has been published. Here we show simple, real-time, interpretable developed from large tertiary hospital China, which validated across five independent, geographically distinct, different tiered hospitals. The containing 20 readily available variables demonstrates consistent, high levels predictive...
Background.Aristolochic acid nephropathy (AAN) is a worldwide problem and one of the common causes chronic kidney disease (CKD) in China.
AKI is a clinical syndrome with various causes involving glomerular, interstitial, tubular, and vascular compartments of the kidney. Acute kidney disease (AKD) new concept that includes both conditions associated subacute decreases in GFR (AKD/non-AKI). This study aimed to investigate correlation between AKI/AKD defined by presentation diffuse histologic criteria for acute abnormalities based on renal biopsy.All 303 patients who were histologically diagnosed as having tubular necrosis (ATN),...