A5032210497- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Sleep and Wakefulness Research
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Traumatic Brain Injury Research
- Neurobiology of Language and Bilingualism
- Genetics and Neurodevelopmental Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Photoreceptor and optogenetics research
- Mental Health and Psychiatry
- Neuroscience and Neural Engineering
- Takotsubo Cardiomyopathy and Associated Phenomena
- Visual perception and processing mechanisms
Yale University
2016-2025
Resonance Research (United States)
2008-2023
University of New Haven
2019-2023
University Hospital Frankfurt
2023
Goethe University Frankfurt
2023
University of Wisconsin–Madison
2023
Hospices Civils de Lyon
2022
Hôpital Femme Mère Enfant
2022
Erasmus Hospital
2022
Université Libre de Bruxelles
2019-2022
Generalized tonic-clonic seizures are among the most dramatic physiological events in nervous system.The brain regions involved during partial with secondary generalization have not been thoroughly investigated humans.We used single photon emission computed tomography (SPECT) to image cerebral blood flow (CBF) changes 59 secondarily generalized from 53 patients.Images were analysed using statistical parametric mapping detect cortical and subcortical commonly affected three different time...
Absence seizures are 5–10 s episodes of impaired consciousness accompanied by 3–4 Hz generalized spike-and-wave discharge on electroencephalography (EEG). The time course functional magnetic resonance imaging (fMRI) changes in absence relation to EEG and behavior is not known. We acquired simultaneous EEG–fMRI 88 typical childhood from nine pediatric patients. investigated concurrently using a continuous performance task or simpler repetitive tapping task. time–frequency analysis revealed...
Abstract This educational topical review and Task Force report aims to address learning objectives of the International League Against Epilepsy (ILAE) curriculum. We sought extract detailed features involving semiology from video recordings interpret semiological signs symptoms that reflect likely localization for focal seizures in patients with epilepsy. glossary was developed by a working group ILAE Commission on Diagnostic Methods incorporating EEG Force. paper identifies commonly used...
The relationship between conscious experience and brain activity has intrigued scientists philosophers for centuries. In the last decades, several theories have suggested different accounts these relationships. These developed in parallel, with little to no cross-talk among them. To advance research on consciousness, we established an adversarial collaboration proponents of two major field, Global Neuronal Workspace Integrated Information Theory. Together, devised preregistered experiments...
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other...
Summary Different theories explain how subjective experience arises from brain activity 1,2 . These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field 3 Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT) 4,5 Global Neuronal Workspace (GNWT) 6–10 , employing a theory-neutral consortium approach 11,12 We investigate neural correlates of content duration...
Functional MRI (fMRI) is widely assumed to measure neuronal activity, but no satisfactory mechanism for this linkage has been identified. Here we derived the changes in energetic component from blood oxygenation level-dependent (BOLD) fMRI signal and related it spiking frequency activated voxels. Extracellular recordings were used cerebral (Δν/ν) of a ensemble during forepaw stimulation α-chloralose anesthetized rat. Under same conditions localized brain energy metabolism (ΔCMR O2 /CMR )...
Temporal lobe seizures are accompanied by complex behavioral phenomena including loss of consciousness, dystonic movements and neuroendocrine changes. These may arise from extended neural networks beyond the temporal lobe. To investigate this, we imaged cerebral blood flow (CBF) changes during human with single photon emission computed tomography (SPECT) while performing continuous video/EEG monitoring. We found that associated consciousness produced CBF increases in lobe, followed bilateral...
Absence seizures (3–4 Hz) and sleep spindles (6–14 occur mostly during slow-wave have been hypothesized to involve the same corticothalamic network. However, mechanism by which this network transforms from one form of activity other is not well understood. Here we examine question using ferret lateral geniculate nucleus slices stimulation tract. A feedback circuit, meant mimic cortical influence in vivo , was arranged such that thalamic burst firing resulted Stimuli were either single shocks...
To study the effects of protein synthesis inhibition on long-term sensitization gill- and siphon-withdrawal reflex Aplysia, we have developed an isolated preparation in which could expose inhibitor to only that part central nervous system involved mediating not other parts animal's system, thus minimizing possible systemic side effects. We found can be obtained gill reflex, this process, but short-term is blocked selectively by anisomycin, a reversible synthesis. Moreover, obtain blockade...
Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used in neuroscience to study brain activity. However, BOLD fMRI does not measure neuronal activity directly but depends on cerebral blood flow (CBF), volume (CBV), and metabolic rate of (CMRO(2)) consumption. Using fMRI, CBV, CBF, recordings, CMRO(2) modeling, we investigated how the signals are related during seizures rats. We found that increases hemodynamic, neuronal, were associated with positive...
Current treatments for epilepsy may control seizures, but have no known effects on the underlying disease. We sought to determine whether early treatment in a model of genetic would reduce severity phenotype adulthood.We used Wistar albino Glaxo rats Rijswijk (WAG/Rij) rats, an established human absence epilepsy. Oral ethosuximide was given from age p21 5 months, covering usual period which seizures develop this (age approximately 3 months). Two experiments were performed: (1) cortical...
Impaired consciousness requires altered cortical function. This can occur either directly from disorders that impair widespread bilateral regions of the cortex or indirectly through effects on subcortical arousal systems. It has therefore long been puzzling why focal temporal lobe seizures so often consciousness. Early work suggested may with dominant seizure involvement. However, other do not More recent supports a 'network inhibition hypothesis' in which disrupt brainstem–diencephalic...
Summary Purpose: Absence seizures cause transient impairment of consciousness. Typical absence occur in children, and are accompanied by 3–4‐Hz spike–wave discharges (SWDs) on electroencephalography (EEG). Prior EEG–functional magnetic resonance imaging (fMRI) studies SWDs have shown a network cortical subcortical changes during these electrical events. However, fMRI typical childhood with confirmed impaired consciousness has not been previously investigated. Methods: We performed EEG‐fMRI...
Seizures have both local and remote effects on nervous system function. Whereas propagated seizures are known to disrupt cerebral activity, little work has been done network of that do not propagate. Human focal temporal lobe demonstrate changes including slow waves electroencephalography (EEG) decreased blood flow (CBF) in the neocortex. Ictal neocortical interpreted as seizure propagation; however, we hypothesize they reflect a depressed cortical state resembling sleep or coma. To...
Summary Purpose: Central nervous system plasticity is essential for normal function, but can also reinforce abnormal network behavior, leading to epilepsy and other disorders. The role of altered ion channel expression in has not been thoroughly investigated. Nav1.6 the most abundantly expressed sodium system. Because its distribution cell body axon initial segment, crucial action potential generation. goal present study was investigate possible changes abnormal, activity‐dependent...
The default mode network has been hypothesized based on the observation that specific regions of brain are consistently activated during resting state and deactivated engagement with task. primary nodes this network, which typically include precuneus/posterior cingulate, medial frontal lateral parietal cortices, thought to be involved in introspective social cognitive functions. Interestingly, same shown selectively impaired epileptic seizures associated loss consciousness. Using a wide...