A5111967755- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Nephrotoxicity and Medicinal Plants
- Ginseng Biological Effects and Applications
- Phytochemistry and Biological Activities
- Drug-Induced Hepatotoxicity and Protection
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Phytochemical Studies and Bioactivities
- Heavy Metals in Plants
- Metabolomics and Mass Spectrometry Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive natural compounds
- Ginger and Zingiberaceae research
- Flavonoids in Medical Research
- Phytoestrogen effects and research
- Plant-based Medicinal Research
- Traditional Chinese Medicine Studies
- Garlic and Onion Studies
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activity of medicinal plants
- Medicinal Plant Pharmacodynamics Research
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Plant Parasitism and Resistance
Peking University
2016-2025
China Medical University
2024
First Hospital of China Medical University
2024
Guangdong Pharmaceutical University
2024
State Key Laboratory of Natural and Biomimetic Drugs
2016
Food and Drug Administration
2016
University of Toyama
2015
Tsinghua University
2014
Hong Kong Baptist University
2009
Kyushu University
2003
Molecular analysis at cellular and subcellular levels, whether on selected molecules or the metabolomics scale, is still a challenge now. Here we propose method based probe ESI mass spectrometry (PESI-MS) for single cell analysis. Detection of metabolites levels was successfully achieved. In our work, tungsten probes with tip diameter about 1 μm were directly inserted into live cells to enrich metabolites. Then enriched desorbed/ionized from (MS) detection. The direct desorption/ionization...
Six new phenolic compounds, named smiglabrone A (1), B (2), smilachromanone (3), smiglastilbene (4), smiglactone (5), smiglabrol (6), together with fifty-seven known ones 7-63 were isolated from the rhizomes of Smilax glabra. Their structures elucidated on basis extensive spectroscopic analyses, as well by comparison literature data. Twenty-seven these compounds obtained and identified in genus for first time. The absolute configuration (2S)-1,2-O-di-trans-p-coumaroylglycerol (43) was...
Taxifolin is a ubiquitous bioactive constituent of foods and herbs. To thoroughly explore its metabolism in vivo, an HPLC-ESI-IT-TOF-MS(n) method combined with specific metabolite detection strategy was used to detect identify the metabolites taxifolin rats. Of 191 tentatively identified, 154 were new metabolites, 69 compounds 32 dimers. This first report vivo biotransformation single compound into more than 100 metabolites. Furthermore, acetylamination pyroglutamic acid conjugation...
Abstract This experiment studied the effect of Cordyceps sinensis extract (CSE) on mice aged by d ‐galactose and castrated rats to analyse its antiaging effect. Water maze step‐down type avoidance tests were used examine CSE learning memory. shortened escape latency, prolonged latency decreased number errors in ‐galactose. The sexual function was evaluated measuring penis erection mount ejaculation latency. appeared shorten rats. study also measured activity age‐related enzymes. results...
Background.Aristolochic acid nephropathy (AAN) is a worldwide problem and one of the common causes chronic kidney disease (CKD) in China.
A comparative study on the triterpene saponins of 47 samples Ginseng drugs derived from 12 Panax taxa was conducted using a reverse-phase high-performance liquid chromatography (HPLC) method. Eleven ginsenosides, which represent 4 types typical sapogenins, were chosen as standards for quantitative determination in order to characterize chemical constituent pattern each drug and investigate relationship between genetic varieties pattern. The results showed that ginsenoside compositions...
To profile absorption of Astragali Radix decoction and identify its orally absorbable constituents their metabolites, four complementary in silico, vitro, vivo methods, i.e., a computational chemistry prediction method, Caco-2 cell monolayer model experiment, an improved rat everted gut sac healthy human volunteer were used. According to the silico computation result, 26 compounds could be regarded as available compounds, including 12 flavonoids. In vitro experiments, 21 tentatively...
The combination of Chinese herbs, Astragali Radix and Angelicae Sinensis Radix, could alleviate renal interstitial fibrosis. Astragaloside IV (AS-IV) ferulic acid (FA) are the two major active constituents in this combination. In study, we employed rats with unilateral ureteral obstruction to determine whether AS-IV FA have same renoprotective effects investigated mechanisms action.Renal pathological changes were evaluated after treatment AS-IV, or + (AF) for 10 days. Meanwhile, expression...
Phytochemical investigation of the n-BuOH-soluble fraction EtOH extract herbaceous stems Ephedra sinica, which is known as Ephedrae Herba in Traditional Chinese Medicine, led to isolation and identification 12 A-type proanthocyanidins, containing five dimers, two trimers tetramers [i.e., (+)-epigallocatechin-(2α→O→7,4α→8)-(-)-catechin, named ephedrannin D1, a dimer; epigallocatechin-(2α→O→7,4α→8)-epigallocatechin-(4α→8)-catechin (ephedrannin Tr1), trimer;...
Abstract Traditional herbal medicines adulterated and contaminated with plant materials from the Aristolochiaceae family, which contain aristolochic acids (AAs), cause acid nephropathy. Approximately 256 traditional Chinese patent medicines, containing Aristolochiaceous materials, are still being sold in markets today. In order to protect consumers health risks due AAs, hidden assassins, efficient methods differentiate herbs their putative substitutes need be established. this study, 158...
Ethnopharmacological relevanceIn the clinical practice of traditional Chinese medicine, concept toxic heat and blood stasis syndrome (THBSS) is commonly observed in many critical diseases. Although herbal medicine Paeoniae Radix Rubra (PRR) has been employed for treating various diseases associated with THBSS, difference pharmacokinetic characteristics its bioactive constituents between such pathological state normal remains unknown.Aim studyTo elucidate profiles six from PRR following oral...
Abstract Background The effects of enterolignans, e.g., enterodiol (END) and particularly its oxidation product, enterolactone (ENL), on prevention hormone-dependent diseases, such as osteoporosis, cardiovascular hyperlipemia, breast cancer, colon prostate cancer menopausal syndrome, have attracted much attention. To date, the main way to obtain END ENL is chemical synthesis, which expensive inevitably leads environmental pollution. explore a more economic eco-friendly production method, we...
Anti-inflammatory compounds were investigated from the ethanol extract of roots and rhizomes Asarum heterotropoides var. mandshuricum, a traditional Chinese medicine called Xixin used for pain inflammatory. Nine new isolated, including six lignans, neoasarinin A-C (1-3), neoasarininoside A B (4 5), asarinin (7), one monoterpene, asarincin (8), two amides, asaramid II III (10 11), natural asaricin (9), along with 37 known (6, 12-47). Their structures absolute configurations elucidated on...