Xiaomei Li
A5100413466- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Tumors Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Oral Health Pathology and Treatment
- Chemokine receptors and signaling
- Systemic Sclerosis and Related Diseases
- Acute Kidney Injury Research
- Adipokines, Inflammation, and Metabolic Diseases
- Gout, Hyperuricemia, Uric Acid
- Organ Transplantation Techniques and Outcomes
- Circadian rhythm and melatonin
- Cardiovascular Function and Risk Factors
Lanzhou University
2021-2025
Lanzhou University Second Hospital
2021-2025
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
Anhui Provincial Hospital
2015-2024
University of Science and Technology of China
2018-2024
Jiangxi University of Traditional Chinese Medicine
2023-2024
National Clinical Research Center for Digestive Diseases
2017-2024
Air Force Medical University
2017-2024
Xijing Hospital
2017-2024
We report the WIMP dark matter search results using first physics-run data of PandaX-II 500 kg liquid xenon dual-phase time-projection chamber, operating at China JinPing Underground Laboratory. No candidate is identified above background. In combination with set during commissioning run, a total exposure 3.3$\times10^4$ kg-day,the most stringent limit to spin-independent interaction between ordinary and for range mass 3.5 1000 GeV/c$^2$. The best upper on scattering cross section found...
The circadian timing system controlled by the suprachiasmatic nuclei (SCN) of hypothalamus regulates daily rhythms motor activity and adrenocortical secretion. An alteration in these is associated with poor survival patients metastatic colorectal or breast cancer. We developed a mouse model to investigate consequences severe dysfunction upon tumor growth.The SCN mice were destroyed bilateral electrolytic lesions, body temperature recorded radio transmitter implanted into peritoneal cavity....
Objectives To investigate beliefs about medicines and their association with medicine adherence in patients chronic diseases China. Design A cross-sectional questionnaire-based study Setting Two large urban hospitals Hefei Tianjin, China Participants Hospital inpatients (313 stroke patients) outpatients (315 diabetic 339 rheumatoid arthritis (RA) were recruited between January 2014 September 2014. Outcome measures The Beliefs Medicines Questionnaire (BMQ), assessing patients’ the specific...
Objective Limited data are available on the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis (PVT). This study aimed to compare transjugular intrahepatic portosystemic shunt (TIPS) covered stents versus endoscopic band ligation (EBL) plus propranolol for among cirrhosis and PVT. Design Consecutive (94% Child-Pugh class A or B) PVT who had bleeding past 6 weeks were randomly assigned TIPS group (n=24) EBL (EBL+drug, n=25), respectively. Primary endpoint was...
Abstract Immune checkpoint blockade (ICB) offers a new opportunity for treatment gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve efficacy ICB therapy. Herein, using CRISPR-Cas9-based genome-wide screening, we identified TRIM28 as one most significant regulators PD-L1, protein, in G.C. cells. Mechanistically, directly binds and stabilizes PD-L1 by inhibiting ubiquitination promoting SUMOylation. Furthermore, facilitates K63...
Background: Disrupted circadian coordination accelerates malignant growth, but the molecular mechanism is unclear. Methods: Healthy or Glasgow osteosarcoma–bearing mice (n = 162) were synchronized with light and darkness over 2–3 weeks, submitted to an 8-hour advance onset of every 2 days (chronic jet lag) disrupt coordination, chronic lag meal timing prevent clock alteration. The expression genes cell cycle c-Myc p53 in liver tumor was determined quantitative reverse...
To analyse the influence of geolocation and ethnicity on clinical presentation primary Sjögren's syndrome (SjS) at diagnosis.The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses performed.We included 7748 women (93%) 562 men (7%), with a mean age diagnosis SjS 53 years. Ethnicity data available for 7884 patients (95%): 6174 (78%)...
Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore plasma levels five (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) their potential as SLE biomarkers. Compared with healthy controls, GAS5 lnc-DC were significantly decreased (P < 0.001 P = 0.002, respectively) while linc0597 overexpressed patients 0.001). When...
The combination of immune checkpoint blockade and chemotherapy has revolutionized the treatment advanced gastric cancer (GC). It is crucial to unravel chemotherapy-induced tumor microenvironment (TME) modulation identify which immunotherapy would improve antitumor effect.
This phase 2b, randomised, double-blind, placebo-controlled trial evaluated the efficacy and safety of telitacicept, a novel fusion protein that neutralises signals B lymphocyte stimulator proliferation-inducing ligand, in active systemic lupus erythematosus (SLE).
Abstract Objective To evaluate the efficacy and safety of telitacicept in adult patients with primary SS (pSS) a phase II randomized double-blind placebo-controlled trial. Methods Patients pSS positive anti-SSA antibody ESSDAI ≥ 5 were randomly assigned, 1:1:1 ratio, to receive weekly subcutaneous 240 mg, 160 or placebo for 24 weeks. The end point was change from baseline at week 24. Safety monitored. Results A total 42 enrolled (n = 14 per group). Administration mg resulted significant...
Type 2 diabetes mellitus (T2DM) is a serious threat to human health and remains incurable. Insulin deficiency seems be attributed the progressive failure of pancreatic islet β-cells immune cells such as T mediated cytotoxicity may involved in loss T2DM. Targeting on system maintain functional activity could an attractive way treat Mesenchymal stem (MSCs) exert potent capacity immunomodulation. MSCs have been successfully applied for treatment several types autoimmune diseases. So, aim this...
We present the results of a search for weakly interacting massive particles (WIMPs) from commissioning run PandaX-II experiment located at China Jinping Underground Laboratory. A WIMP data set with an exposure $306\ifmmode\times\else\texttimes\fi{}19.1\text{ }\text{ }\mathrm{kg}\text{\ensuremath{-}}\text{day}$ was taken, while its dominant $^{85}\mathrm{Kr}$ background used as electron recoil calibration. No candidates are identified, and 90% upper limit is on spin-independent elastic...