A5060020912- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Polyamine Metabolism and Applications
- Folate and B Vitamins Research
- Cerebrovascular and Carotid Artery Diseases
- Cancer Research and Treatments
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- Head and Neck Cancer Studies
- RNA Interference and Gene Delivery
- S100 Proteins and Annexins
- RNA modifications and cancer
- Pharmacological Effects and Toxicity Studies
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Head and Neck Surgical Oncology
- Chemical Synthesis and Analysis
- Hepatitis Viruses Studies and Epidemiology
- Amino Acid Enzymes and Metabolism
- Extracellular vesicles in disease
Henan University
2015-2025
Beijing Anzhen Hospital
2018-2024
Capital Medical University
2016-2024
Huashan Hospital
2010-2024
Fudan University
2013-2024
Jinzhou Kangning Hospital
2024
Shenzhen KangNing Hospital
2021-2024
Shanxi Cardiovascular Hospital
2023-2024
Fujian Provincial Hospital
2024
Xijing Hospital
2013-2023
Background: Stroke is a leading cause of adult disability that can severely compromise the quality life patients, yet no effective medication currently exists to accelerate rehabilitation. A variety circular RNA (circRNA) molecules are known function in ischemic brain injury. Lentivirus-based expression systems have been widely used basic studies circRNAs, but safety issues with such delivery limited exploration potential therapeutic roles for circRNAs. Methods: Circular SCMH1 (circSCMH1)...
Objective Limited data are available on the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis (PVT). This study aimed to compare transjugular intrahepatic portosystemic shunt (TIPS) covered stents versus endoscopic band ligation (EBL) plus propranolol for among cirrhosis and PVT. Design Consecutive (94% Child-Pugh class A or B) PVT who had bleeding past 6 weeks were randomly assigned TIPS group (n=24) EBL (EBL+drug, n=25), respectively. Primary endpoint was...
To evaluate the long-term outcomes of percutaneous recanalization and determine predictors patency survival in a large case series Chinese patients with Budd-Chiari syndrome (BCS).This retrospective study was approved by institutional ethics committee. Informed consent for procedure obtained from all patients. Between July 1999 August 2010, 177 consecutive primary BCS were treated followed up until death or their last clinical evaluation. Recanalization therapeutic strategy complications...
Stroke is a leading cause of death and disability but most the clinical trials have failed in past, partially because majority current approaches are focusing on neural protection rather than neuroregeneration. In this study, we report an vivo regeneration approach through AAV NeuroD1-based gene therapy to repair damaged brains after ischemic stroke adult non-human primates (NHPs). We demonstrate that ectopic expression transcription factor NeuroD1 reactive astrocytes monkey cortical can...
Transition-metal dyshomeostasis has been identified as a critical pathogenic factor for the aggregates of amyloid-beta (Aβ) peptide, which is associated with onset and progression Alzheimer's disease (AD). Excessive transition-metal ions, especially copper ion (Cu2+ ), catalyze formation reactive oxygen species (ROS), triggering neuroinflammation neuronal cell apoptosis. Therefore, developing robust chelating agent can not only efficiently bind toxic Cu2+ , but also simultaneously scavenge...
Brain size and cognitive skills are the most dramatically changed traits in humans during evolution yet genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys (8 first-generation 3 second-generation) carrying human copies of
INTRODUCTION: Current guidelines recommend anticoagulation as the mainstay of portal vein thrombosis (PVT) treatment in cirrhosis. However, because heterogeneity PVT, alone does not always achieve satisfactory results. This study aimed to prospectively evaluate an individualized management algorithm using a wait-and-see strategy (i.e., no treatment), anticoagulation, and transjugular intrahepatic portosystemic shunt (TIPS) treat PVT METHODS: Between February 2014 June 2018, 396 consecutive...
Abstract Background Treatment options for refractory metastatic colorectal cancer (mCRC) were limited. Anlotinib is a novel multitarget tyrosine kinase inhibitor. ALTER0703 study was conducted to assess efficacy and safety of anlotinib patients with mCRC. Materials Methods This multicenter, double-blinded, placebo-controlled, randomized phase III trial involving 33 hospitals in China. Patients had taken at least two lines therapies 2:1 receive oral (12 mg/day; days 1–14; 21 per cycle) or...
The role of transjugular intrahepatic portosystemic shunt (TIPS) for the secondary prophylaxis variceal bleeding in cirrhotic patients with portal vein thrombosis (PVT) remains obscure. This prospective cohort study aimed to assess risk factors associated TIPS technical success, outcome and prognosis PVT a history bleeding.Between May 2009 April 2011, 51 who attempted procedures prevention rebleeding were enrolled.TIPS success rate was 84% (43/51). An increased degree within trunk branches...
Little is known about the changes in allergen sensitization China secondary to environmental variations over past decade. We aimed at investigating among asthma and/or rhinitis patients between 2008 and 2018.This study analyzed cross-sectional data from national surveys conducted 2018. After finishing questionnaire, participants underwent serum specific IgE measurements. A total of 2322 2798 were enrolled 2018, respectively. The significance differences rates four regions assessed....
Background: P-glycoprotein (P-gp) mediated drug efflux across the blood–brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as carriers, can overcome P-gp activity and improve targeted delivery AEDs. However, their applications in AEDs have not been adequately investigated. The objective this study was to develop a nano-scale system solubility lamotrigine (LTG). Methods: LTG-loaded Pluronic ® P123 (P123)...