A5081643835- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Surgical Treatments
- Hydrology and Watershed Management Studies
- Hydrological Forecasting Using AI
- Breast Lesions and Carcinomas
- Circular RNAs in diseases
- Colorectal and Anal Carcinomas
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
First Hospital of China Medical University
2016-2025
China Medical University
2016-2025
Nanchang University
2019-2025
Zhengzhou University
2021-2025
Henan University
2024-2025
Shandong University
2010-2025
First Affiliated Hospital of Jiangxi Medical College
2025
State Key Laboratory of Microbial Technology
2022-2025
Central China Normal University
2025
University of Chinese Academy of Sciences
2017-2024
Abstract Background MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a miR-152 significantly down-regulated gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" miR-152. Although aberrant expression of been observed several types cancer, its pathophysiologic role relevance to tumorigenesis still largely unknown. The purpose this study was elucidate...
Magnetic hyperthermia therapy (MHT) is noninvasive and features excellent tissue penetration for deep-seated tumors, but unfortunately, it suffers the low therapeutic efficacy due to limited magneto-thermal efficiency insufficient intratumor accumulation of conventional intravenous-injected magnetic nanoparticles, which are actually mostly sequestered by mononuclear phagocyte system, especially liver. Such a disadvantageous characteristic preferential liver uptake here exploited, first time...
Periodontitis is a chronic inflammatory disease deriving from dental plaque, characterized by the excessive accumulation of reactive oxygen species (ROS), matrix metalloproteinase (MMP) and other substances, resulting in destruction periodontal tissues. At present, main therapeutic modalities, such as local mechanical debridement antibiotic delivery, are not only difficult to solve intractable bacterial biofilm effectively but also tricky ameliorate response well regenerate impaired Herein,...
Abstract Purpose RC48 contains the novel humanized anti-HER2 antibody hertuzumab conjugated to MMAE via a cleavable linker. A phase I study was initiated evaluate toxicity, MTD, PK, and antitumor activity of in patients with HER2-overexpressing locally advanced or metastatic solid carcinomas, particularly gastric cancer. Patients methods This 2-part study. Successive cohorts received escalating doses (0.1 mg/kg, 0.5 1.0 2.0 2.5 3.0 mg/kg). Dose expansion proceeded at dose mg/kg Q2W. The...
Fungal infection possesses the characteristics of high invasion depth and easy formation a biofilm under skin, which greatly hinders treatment process. Here, traditional Chinese medicine moxa is carbonized modified with zinc oxide (ZnO) nanosheets to synthesize moxa@ZnO (CMZ) dual response properties yellow light (YL) ultrasound (US) for synergistic antifungal therapy. CMZ narrow bandgap can respond long-wavelength YL that highly safe helpful skin repair. Simultaneously, piezoelectric effect...
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) have potential applications as food additives, but concerns persist about their safety. Children are identified having the highest exposure and may face greatest health risks. However, toxicological sensitivity of TiO NPs in different ages is not clear. Here, a comparative toxicity study 3‐week (youth) 8‐week (adult) old Sprague‐Dawley rats reported following oral at doses 0, 10, 50, 200 mg kg −1 body weight per day for 30 days. The organ...
Aberrant expression of miR-335 has been frequently reported in cancer studies, suggesting that there is a close correlation between and during its development, progression, metastasis prognosis. The gastric effects are not known. Relative 4 cell lines 70 tissues was confirmed by real-time quantitative reverse transcriptase-PCR compared with controls. Transwell migration Matrigel invasion assay vitro formation vivo were used to examine the on metastasis. effect proliferation estimated...
An original gadolinium-hybridized plasmonic gold nanocomposite is fabricated to provide an insightful and attractive strategy overcome both the physiological pathological barriers of tumor, increase transportation permeability imaging agents drugs in tumor interior for achieving high-sensitive multimodal simultaneously improving therapeutic efficacy cancer. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may...
Abstract Long noncoding RNAs (lncRNAs) are known to regulate the development and progression of various cancers. However, few lncRNAs have been well characterized in lung adenocarcinoma (LUAD). Here, we identified expression profile protein-coding genes via microarrays analysis paired LUAD tissues adjacent non-tumor from five female non-smokes with LUAD. A total 498 1691 were differentially expressed between normal tissues. novel lncRNA, transcript 1 (LUADT1), which is highly correlates T...
Breast cancer is a prominent cause of death among women worldwide. Recent studies have demonstrated that artemisinin (ART) displays anti-tumor activity. Using mouse breast model, we investigated the effects ART in vitro and vivo to determine how it influences immune response. We measured proliferation apoptosis 4T1 cells after treatment by MTT assay FACS. To examine vivo, tumor volumes survival rates were tumor-bearing mice. FACS was used frequencies Tregs, MDSCs, CD4+ IFN-γ+ T cells, CTLs...
Helicobacter pylori (H. pylori) infection is the leading cause of chronic gastritis, peptic ulcer, and gastric cancer. Antibiotics, as traditional method for eliminating H. pylori, have no targeting effect, which causes serious bacterial resistance gut dysbacteriosis. Moreover, antibiotics can hardly address hyperactive inflammatory response or damaged mucosal barrier caused by infection. Here, a pH-responsive metal-organic framework hydrogen-generation nanoparticle (Pd(H) @ ZIF-8) reported,...
Periodontitis is a bacterial infectious disease leading to the loss of periodontal supporting tissues and teeth. The current guided tissue regeneration (GTR) membranes for periodontitis treatments cannot effectively promote limited antibacterial properties excessively fast degradation rate. Besides, they need extra tailoring according variform defects before implantation, imprecise match. This study proposed an injectable sodium alginate hydrogel composite (CTP-SA) doped with cubic cuprous...
Osteoporosis is one of the most common diseases affecting bone metabolism. Nitric oxide (NO), an endogenous gas molecule involved in osteogenesis, can effectively promote proliferation and differentiation osteoblasts. Although exogenous NO reverse osteoporosis to a certain extent, transitory half-life short diffusion radius severely limit its application. In this work, generation nanoplatform with targeting property (UCPA) developed based on upconversion nanoparticles (UCNPs) that convert...
Abstract The use of gaseous and air-captured CO 2 for technical biosynthesis is highly desired, but elusive so far due to several obstacles including high energy (ATP, NADPH) demand, low thermodynamic driving force limited rate. Here, we present an ATP NAD(P)H-free chemoenzymatic system amino acid pyruvate by coupling methanol with . It relies on a re-engineered glycine cleavage the NAD(P)H-dependent L protein replaced biocompatible chemical reduction H dithiothreitol. latter provides higher...