A5100326831- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Genomics and Phylogenetic Studies
- Cancer Cells and Metastasis
- Soil Carbon and Nitrogen Dynamics
- Plant Stress Responses and Tolerance
- RNA Interference and Gene Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- interferon and immune responses
- Plant Molecular Biology Research
- RNA Research and Splicing
- Immune cells in cancer
- Natural product bioactivities and synthesis
- Metal-Organic Frameworks: Synthesis and Applications
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Viral gastroenteritis research and epidemiology
- Autophagy in Disease and Therapy
- Photosynthetic Processes and Mechanisms
First Affiliated Hospital of Xi'an Jiaotong University
2014-2025
Dalian Medical University
2013-2025
Second Affiliated Hospital of Dalian Medical University
2013-2025
Northwest A&F University
2016-2025
Dalian Institute of Chemical Physics
2013-2025
Chinese Academy of Sciences
2015-2025
Xiangyang Central Hospital
2023-2025
Soochow University
2014-2025
Zhejiang A & F University
2014-2025
First Affiliated Hospital of Soochow University
2019-2025
Chemosynthetic symbioses are partnerships between invertebrate animals and chemosynthetic bacteria. The latter the primary producers, providing most of organic carbon needed for animal host's nutrition. We sequenced genomes symbionts from lucinid bivalve Loripes lucinalis stilbonematid nematode Laxus oneistus. both host species encoded nitrogen fixation genes. This is remarkable as no marine symbiont was previously known to be capable fixation. detected nitrogenase expression by clams at...
Microbial community structure can be analyzed by quantifying cell numbers or biomass for individual populations. Methods are already available (e.g., fluorescence in situ hybridization, 16-S rRNA gene amplicon sequencing), yet high-throughput methods assessing terms of lacking. Here we present metaproteomics-based microbial using protein abundance as a measure contributions We optimize the accuracy and sensitivity method artificially assembled communities show that it is less prone to some...
Emerging evidence suggests that metabolic adaptation is a vital hallmark and prerequisite for macrophage phenotype transition.Pyruvate kinase M2 (PKM2) an essential molecular determinant of adaptions in pro-inflammatory macrophages.Post-translational modifications play central role the regulation PKM2.However, doubt remains on whether lactylation PKM2 exists how modulates function PKM2.For first time, our study reports lactate inhibits Warburg effect by activating PKM2, promoting transition...
A simple microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay was developed for rapid COVID-19 detection.
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
Abstract Purpose RC48 contains the novel humanized anti-HER2 antibody hertuzumab conjugated to MMAE via a cleavable linker. A phase I study was initiated evaluate toxicity, MTD, PK, and antitumor activity of in patients with HER2-overexpressing locally advanced or metastatic solid carcinomas, particularly gastric cancer. Patients methods This 2-part study. Successive cohorts received escalating doses (0.1 mg/kg, 0.5 1.0 2.0 2.5 3.0 mg/kg). Dose expansion proceeded at dose mg/kg Q2W. The...
Abstract Insufficient activation of the stimulator interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits effect cancer immunotherapy. Herein, tumor (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING Toll‐like receptor 4 (TLR4) to augment via TLR4‐mediated nuclear factor‐kappa B stimulation, leading increased secretion type I interferons (i.e., 4.0‐fold enhancement IFN‐β) pro‐inflammatory cytokines...
Abstract Background The majority of epidemiological studies on migraine have been conducted in a specific country or region, and there is lack globally comparable data. We aim to report the latest information global incidence overview trends from 1990 2019. Methods In this study, available data were obtained Global Burden Disease present temporal for world its 204 countries territories over past 30 years. Meanwhile, an age-period-cohort model be used estimate net drifts (overall annual...
Chaperone-mediated autophagy (CMA), a proteolytic system contributing to the degradation of intracellular proteins in lysosomes, is upregulated tumors for pro-tumorigenic and pro-survival purposes. In this study, bioinformatics analysis revealed co-occurrence CMA PD-L1 accumulation metastatic melanoma with adaptive immune resistance (AIR) anti-PD1 treatment, suggesting potential therapeutic effects rewiring degradation. Furthermore, attributed IFN-γ-mediated compensatory up-regulation CMA,...
Although the antibody-drug conjugates (ADCs) have significantly improved survival outcomes of patients with human epidermal receptor 2 (HER2)-expressing gastric or gastroesophageal junction (G/GEJ) cancer, efficacy ADC used as a single agent is limited. Therefore, it necessary to investigate effective and safe combination regimens. Preclinical data indicated synergetic antitumour effect RC48 programmed cell death protein 1 (PD-1) inhibitors. We aimed evaluate safety plus toripalimab in...
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells...
Abstract Background While circulating metabolites have been increasingly linked to cancer risk, the causality underlying these associations remains largely uninterrogated. Methods We conducted a comprehensive 2-sample Mendelian randomization (MR) study evaluate potential causal relationship between 913 plasma and risk of seven cancers among European-ancestry individuals. Data on variant-metabolite were obtained from genome-wide association (GWAS) 14,296 subjects. variant-cancer gathered...
Abstract Background Ovarian cancer (OC) is a malignant neoplasm that displays increased vascularization. Angiopoietin-like 4 (ANGPTL4) secreted glycoprotein functions as regulator of cell metabolism and angiogenesis plays critical role in tumorigenesis. However, the precise ANGPTL4 OC microenvironment, particularly its involvement angiogenesis, has not been fully elucidated. Methods The expression was confirmed by bioinformatics IHC OC. potential molecular mechanism measured RNA-sequence. We...
Abstract Biochar and organic fertilizer substitution have been utilized to improve crop yields promote sustainable agricultural development. However, few studies focused on how biochar regulate the diversities of bacterial meta-communities sub-communities (i.e., habitat specialists generalists) within soil aggregates Loess Plateau. A field experiment, containing six treatments, namely no (CK), plus 10 4 kg ha −1 (CK + B), traditional N (TF, 150 ), (TF replacing (OF), (OF was adopted explore...
Atherosclerosis (AS) is the principal pathological cause of atherosclerotic cardiovascular diseases. Chronic endoplasmic reticulum stress (ERS) has been implicated in AS aetiopathogenesis, but underlying molecular interactions remain unclear. This study aims to identify mechanisms ERS pathogenesis inform innovative diagnostic approaches and therapeutic targets for managing AS. GSE28829 GSE43292—human early advanced carotid tissue samples—were obtained from Gene Expression Omnibus database....
Abstract Epithelial cadherin (E‐cadherin) is a Ca 2+ ‐dependent cell‐cell adhesion molecule that connects cells via homotypic interactions. Its function critical in the induction and maintenance of cell polarity differentiation, its loss downregulation associated with an invasive poorly differentiated phenotype colon other tumours. We have used avidin‐biotin immunoperoxidase technique to localize E‐cadherin microwave‐treated, paraffin‐embedded sections from 36 patients pancreatic...