A5101456018- Tryptophan and brain disorders
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Metabolomics and Mass Spectrometry Studies
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Stress Responses and Cortisol
- Gut microbiota and health
- Child and Adolescent Psychosocial and Emotional Development
- Enterobacteriaceae and Cronobacter Research
- Attention Deficit Hyperactivity Disorder
- Intraocular Surgery and Lenses
- Antibiotics Pharmacokinetics and Efficacy
- Treatment of Major Depression
- Toxic Organic Pollutants Impact
- Healthcare professionals’ stress and burnout
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy metals in environment
- Salivary Gland Disorders and Functions
- Neuroscience and Neuropharmacology Research
- Pesticide Exposure and Toxicity
- Ocular Surface and Contact Lens
- Mental Health Research Topics
- Cancer, Hypoxia, and Metabolism
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Chongqing Public Health Medical Center
2022-2025
South China Agricultural University
2014-2025
Ministry of Agriculture and Rural Affairs
2025
Research Center for Eco-Environmental Sciences
2018-2024
Chinese Academy of Sciences
2018-2024
Peking University Third Hospital
2019-2024
California University of Pennsylvania
2022-2024
Peking University
2019-2024
Abstract The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), provides family database resources to support global academic and industrial communities. With rapid accumulation multi-omics data at an unprecedented pace, CNCB-NGDC continuously expands updates core through big archiving, integrative analysis value-added curation. Importantly, NGDC collaborates closely with major international databases initiatives ensure seamless exchange...
The objective of this study was to assess the impact diverse plasmids bearing colistin resistance gene mcr-1 on host fitness. Forty-seven commensal E. coli isolates recovered from pig farm where first identified were screened for mcr-1. mcr-1-bearing characterized by sequencing. fitness evaluated in vitro competition assays. Twenty-seven (57.5%) positive genes mainly located belonging IncI2 (n = 5), IncX4 11), IncHI2/ST3 8), IncFII 2), and IncY 2). InHI2 also carried other (floR, blaCTX-M,...
ABSTRACT mcr-1 was initially reported as the first plasmid-mediated colistin resistance gene in clinical isolates of Escherichia coli and Klebsiella pneumoniae China has subsequently been identified worldwide various species family Enterobacteriaceae . encodes a phosphoethanolamine transferase, its expression shown to generate phosphoethanolamine-modified bis-phosphorylated hexa-acylated lipid A E. Here, we investigated effects on susceptibility lipopolysaccharide structures laboratory...
Abstract Extensive research has been carried out on the metabolomic changes in animal models of depression; however, there is no general agreement about which metabolites exhibit constant changes. Therefore, aim this study was to identify consistently altered large-scale metabolomics studies depression models. We performed vote counting analyses upregulated or downregulated brain, blood, and urine based 3743 differential from 241 studies. found that serotonin, dopamine, gamma-aminobutyric...
Importance No clinically applicable diagnostic test exists for severe mental disorders. Lipids harbor potential as disease markers. Objective To define a reproducible profile of lipid alterations in the blood plasma patients with schizophrenia (SCZ) independent demographic and environmental variables to investigate its specificity association other psychiatric disorders, ie, major depressive disorder (MDD) bipolar (BPD). Design, Setting, Participants This was multicohort case-control...
The objective of this study was to determine the minimal inhibitory concentration colistin for Escherichia coli from food animals and possible underlying resistance mechanisms. During 2007–2014, 4,438 E. isolates animal origins were collected. susceptibility tested by agar dilution method. Mutations in pmrA, pmrB, mgrB presence mcr-1 gene determined PCR DNA sequencing. Complementation experiments carried out evaluate contribution mutations resistance. There a high frequency pigs on farm...
The purpose of this study was to examine the occurrence fosfomycin-resistant Escherichia coli from chickens and characterize plasmids carrying fosA3. A total 661 E. isolates chicken origin collected 2009 2011 were screened for plasmid-mediated fosfomycin resistance determinants by PCR. Plasmids characterized using PCR-based replicon typing, plasmid multilocus sequence restriction fragment length polymorphisms. Associated addiction systems genes identified PCR-mapping used analysis genetic...
Major depressive disorder (MDD) is a common mood disorder. Gut microbiota may be involved in the pathogenesis of depression via microbe-gut-brain axis. Liver vulnerable to exposure bacterial products translocated from gut portal vein and In this study, germ-free mice underwent fecal transplantation MDD patients healthy controls. Behavioral tests verified model. Metabolomics using gas chromatography-mass spectrometry, nuclear magnetic resonance, liquid spectrometry determined influence...
Abstract Numerous studies have investigated metabolite alterations resulting from pharmacological treatment in depression models although few quantitative explored metabolites exhibiting constant alterations. This study aimed to identify consistently dysregulated across such using a knowledgebase-driven approach. was based on 157 that identified an assembly of 2757 differential the brain, blood, urine, liver, and feces samples with medication. The use vote-counting approach upregulated...
Introduction Schizophrenia is a complex psychiatric disorder, of which molecular pathogenesis remains largely unknown. Accumulating evidence suggest that gut microbiota may affect brain function via the gut-brain axis, be potential contributor to schizophrenia. However, alteration showed high heterogeneity across different studies. Therefore, this study aims identify consistently altered microbial taxa associated with Methods We conducted systematic search and synthesis up-to-date human...