A5051167940- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Neuroendocrine regulation and behavior
- Gut microbiota and health
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Birth, Development, and Health
- Biochemical effects in animals
- Dementia and Cognitive Impairment Research
- Neuropeptides and Animal Physiology
- Clostridium difficile and Clostridium perfringens research
- Neuroinflammation and Neurodegeneration Mechanisms
- Ultrasound and Hyperthermia Applications
- Microscopic Colitis
- Metabolomics and Mass Spectrometry Studies
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
Federal Medical Research Centre for Psychiatry and Narcology
2014-2025
Moscow Research and Clinical Center for Neuropsychiatry
2013-2025
Ministry of Health of the Russian Federation
2011-2025
Kharkiv Regional Clinical Psychiatric Hospital No 3
2025
Vavilov Institute of General Genetics
2020-2024
Russian Academy of Sciences
2024
Federal Center Research Fundamentals of Biotechnology
2024
Mental Health Commission
2022-2023
Moscow Regional Psychiatry Hospital No.5
2023
Pirogov Russian National Research Medical University
2011
Importance No clinically applicable diagnostic test exists for severe mental disorders. Lipids harbor potential as disease markers. Objective To define a reproducible profile of lipid alterations in the blood plasma patients with schizophrenia (SCZ) independent demographic and environmental variables to investigate its specificity association other psychiatric disorders, ie, major depressive disorder (MDD) bipolar (BPD). Design, Setting, Participants This was multicohort case-control...
Nowadays, depressive disorder is spreading rapidly all over the world. Therefore, attention to studies of pathogenesis disease in order find novel ways early diagnosis and treatment increasing among scientific medical communities. Special drawn a biomarker therapeutic strategy through microbiota–gut–brain axis. It known that symbiotic interactions between gut microbes host can affect mental health. The review analyzes mechanisms action microbiota on pathophysiology depression. possibility...
Major depressive disorder (MDD) is among the most prevalent mental disorders worldwide. Factors causing pathogenesis of MDD include gut microbiota (GM), which interacts with host through gut-brain axis. In previous studies GM in patients, 16S rRNA sequencing was used, provided information about composition but not function. our study, we analyzed whole metagenome data to assess changes both and functional profile GM. We looked at 36 compared that 38 healthy volunteers. Comparative taxonomic...
Inflammatory bowel disease (IBD) is highly prevalent globally and, in the majority of cases, remains asymptomatic during its initial stages. The gastrointestinal microbiota secretes volatile organic compounds (VOCs), and their composition alters IBD. examination VOCs could prove beneficial complementing diagnostic techniques to facilitate early identification IBD risk. In this protocol, a model sodium dextran sulfate (DSS)-induced colitis rats was successfully implemented for non-invasive...
BACKGROUND: Functional and structural studies of the brain highlight importance white matter alterations in schizophrenia. However, molecular associated with disease remain insufficient. AIM: To study lipidome transcriptome composition corpus callosum schizophrenia, including analyzing a larger number biochemical lipid compounds their spatial distribution sections, data. integrate results approaches to create comprehensive perspective disease. METHODS: A total 8 tissue samples (4 from...
Some studies suggest that Toxoplasma gondii infection may increase the risk of developing schizophrenia. Determining changes in blood biomarker concentrations provide new insights into underlying mechanisms associated with The aim study was to evaluate several serum neurobiological and immune parameters identify their could potentially be indicators psychopathologic infection. concentration biomarkers determined from patients schizophrenia (uninfected n = 50, infected 30) mentally healthy...
Background: Cognitive decline during aging is a factor that inevitably affects everyone. In some older adults, cognitive function declines more rapidly to mild impairment (MCI) and eventually dementia. Our work aimed determine the associations between suicide-related single-nucleotide genetic polymorphisms (SNPs) dynamics in people over 65 years old three-year follow-up. Suicide-related SNPs have already shown an association with dementia our previous study. Methods: The present study...
ABSTRACT Inflammatory bowel diseases are characterized by chronic intestinal inflammation and alterations in the gut microbiota composition. Bacteroides fragilis , which secretes outer membrane vesicles (OMVs) with polysaccharide A (PSA), can moderate inflammatory response possibly alter In this study, we created a murine model of sodium dextran sulfate (DSS)-induced colitis treated it B. OMVs. We monitored efficiency OMV therapy determining disease activity index (DAI) performing...
Willner's "chronic mild stress" (CMS) model is a globally recognized and most commonly used depression model. A induced by ultrasonic exposure of variable frequencies has been created in our laboratory. This article compares two models the depressive-like state according to three validity criteria. Face demonstrated sucrose preference test, Porsolt social interest, open field Morris water maze. Rats after ultrasound impact have more pronounced anhedonia isolation. The construct proven due...
We investigated the associations of rs4680 COMT, rs6280 DRD3 and rs7322347 5HT2A with youth-onset schizophrenia in Russian population a case-control study, role genotype severity clinical features. The association between (p = 0.0001) is described for first time. Furthermore, we found link females 0.001 p 0.02 respectively) males 0.002). Clinical symptoms were assessed on three scales: Clinician-Rated Dimensions Psychosis Symptom Severity scale, PANSS FAB. Gender differences features are...
Fetal development is susceptible to environmental factors. One such factor exposure stress during pregnancy. The present study aimed investigate the effects of chronic prenatal (PS) on and behavior rat offspring infancy juvenile ages. Existing approaches modeling animals do not correlate with main type in pregnant women, namely psychological stress. We used a new paradigm experiment, namely, induced by variable frequency ultrasound (US), which acted Wistar rats gestational days 1–21. This...
The detection of specific markers dementia and mild cognitive decline (MCI) could be the key to disease prevention forehanded treatment. Female gender is one major risk factor for dementia. aim our study was compare serum concentration some factors related lipid metabolism immune system in patients with MCI performed on women >65 years old: controls (n = 75), diagnosed 73) 142). Patients were evaluated using Mini-Mental State Examination, Clock Drawing Test Montreal Cognitive Assessment...
Vindeburnol (VIND, RU24722, BC19), a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological effects, but its antidepressant-like effects are poorly understood and have only been described in few patents. To reliably estimate this effect, vindeburnol was studied model of long-term variable-frequency ultrasound (US) exposure at 20–45 kHz male Wistar rats BALB/c mice. administered chronically for 21 days against background simultaneous dose...
Schizophrenia is a psychiatric disorder known to affect brain structure and functionality. Structural changes in the at level of gross anatomical structures have been fairly well studied, while microstructural changes, especially those associated with molecular composition brain, are still being investigated. Of special interest lipids metabolites, for which some previous studies shown association schizophrenia.
We investigated the associations of DRD3 rs6280, HTR1A rs6295, BDNF rs6265, SCL6A4 rs16965628, and 5HT2A rs7322347 with schizophrenia in a case–control study, these genetic variants several clinical features. also markers inflammatory response (C-reactive protein, IL-2, IL-6, IL-10), activity leukocytic elastase (LE) α1-proteinase inhibitor (a1-PI), antibodies to S100B myelin basic protein (MBP) schizophrenia. Clinical symptoms were assessed on three scales: Positive Negative Syndrome Scale,...
Emotional stress is considered a serious pathogenetic factor of depression. In this study an ultrasound model emotional developed in our laboratory was applied. It characterized by the use as stressor agent. Animals are triggered not any organic or physical disturbances but perception adverse information. This type can induce depressive-like behavioral changes rodents, manifested decreased sucrose preference and increased time immobility forced swim test. Ultrasound also levels oxidative...