A5100440855- Liver physiology and pathology
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Reconstructive Surgery and Microvascular Techniques
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Reproductive System and Pregnancy
- Pancreatitis Pathology and Treatment
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Pelvic and Acetabular Injuries
- Autoimmune and Inflammatory Disorders Research
- Endometrial and Cervical Cancer Treatments
- Advanced biosensing and bioanalysis techniques
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
Deleted Institution
2025
Soochow University
2023-2025
First Affiliated Hospital of Soochow University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
First Affiliated Hospital of Anhui Medical University
2023-2024
Hainan Medical University
2022-2024
First Affiliated Hospital of Shihezi University Medical College
2011-2024
Shihezi University
2024
Huazhong University of Science and Technology
2021-2024
Tongji Hospital
2022-2024
4500 Background: Programmed death-1 (PD-1) inhibitor–based combination therapy shows clinical benefit in first-line accRCC. However, data are limited on impact of PD-1 inhibitor monotherapy. KEYNOTE-427 (NCT02853344) is a single-arm, open-label, 2-cohort, phase 2 study that evaluates efficacy and safety the pembrolizumab (pembro) as monotherapy accRCC anccRCC. Results from cohort (cohort A) presented. Methods: Patients (pts) with histologically confirmed who received no prior systemic were...
Influenza vaccines elicit antigen-specific antibodies and immune memory to protect humans from infection with drift variants. However, what supports or limits vaccine efficacy duration is unclear. Here, we vaccinated healthy volunteers annual formulations investigated the dynamics of T cell, natural killer (NK) cell antibody responses upon restimulation heterologous homologous influenza virus strains. induced potential NK cells increased recall IFN-γ during first 6 months. In absence...
Lysine crotonylation is a newly discovered protein post-translational modification and was reported to share transferases deacylases with lysine acetylation. The acetyltransferase p300 also contain crotonyltransferase activity, class I histone deacetylases were demonstrated be the major decrotonylases. However, decrotonylases for nonhistone proteins are unclear. Moreover, because of lack high-quality pan-antibodies, large-scale analysis crotonylome still remains challenge. In this work, we...
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has been confirmed altering viral antigenicity resulting immune escape. To identify crucial mutations that escape humoral response, we evaluated cross-neutralization convalescent plasmas and RBD-specific monoclonal antibodies (mAbs) against various protein-based pseudoviruses. Three 24 pseudoviruses containing different protein, including...
To determine serum cytokine profiles in Graves’ disease (GD) patients with or without active and inactive thyroid associated ophthalmopathy (TAO), we recruited 65 subjects: 10 GD only (without TAO), 25 + TAO, 20 healthy controls. Liquid chip assay was used to measure Th1/Th2/Th17 cytokines including IFN- γ (interferon-gamma), TNF- α (tumor necrosis factor-alpha), IL-1 (interleukin-1 alpha), IL-1Ra (IL-1 receptor antagonist), IL-2, IL-4, IL-6, IL-17 two chemokines: RANTES (regulated upon...
Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) has emerged as a novel therapy for acute liver failure (ALF). However, the homing efficiency BMSCs to injured sites appears be poor. In this study, we aimed determine if overexpression c-Met in could promote ability rat livers affected by ALF.Overexpression (c-Met-BMSCs) was attained transfection naive with lenti-c-Met-GFP. The impact transplanted c-Met-BMSCs on both and repair ALF evaluated compared lenti-GFP empty vector...
Background Stomolophus meleagris envenomation causes severe cutaneous symptoms known as jellyfish dermatitis. The potential molecule mechanisms and treatment efficiency of dermatitis remain elusive because the complicated venom components. biological activity molecular regulation mechanism Troxerutin (TRX) was firstly examined a for Methods We inhibit effects TRX on tentacle extract (TE) obtained from S. in vivo vitro using mice paw swelling models corresponding assays Enzyme-Linked...
Recent studies have described beneficial effects of an infusion mesenchymal stem cells (MSCs) derived from Wharton’s jelly tissue, for the treatment acute liver failure (ALF). However, data on therapeutic potential culture-expanded MSCs are lacking. We examined passage five (P5) and ten (P10) human umbilical cord- (hUC-) via their transplantation into Sprague-Dawley (SD) rats with D-galactosamine (D-GalN) LPS-induced SD were randomly divided three groups: control group, P5 hUC-MSCs P10...
Idiopathic pulmonary fibrosis (IPF) is a progressing lethal disease with few clinically effective therapies. Corilagin tannin derivative which shows anti-inflammatory and antifibrotics properties potentiated in treating IPF. Here, we investigated the effect of corilagin on lung injury following bleomycin exposure an animal model fibrosis. abrogated bleomycin-induced as assessed by H&E; Masson's trichrome staining hydroxyproline content tissue. reduced number apoptotic cells prevented...
Abstract The outbreak of the novel coronavirus disease 2019 (COVID-19) infection began in December Wuhan, and rapidly spread to many provinces China. number cases has increased markedly Anhui, but information on clinical characteristics patients is limited. We reported 75 with COVID-19 First Affiliated Hospital USTC from Jan 21 Feb 16, 2020, Hefei, Anhui Province, was confirmed by real-time RT-PCR respiratory nasopharyngeal swab samples. Epidemiological, laboratory data were collected...
Abstract Acetaminophen (APAP)-induced liver injury (AILI) is the most frequent cause of acute failure; but underlying mechanisms still remain obscure. Macrophages and endoplasmic reticulum (ER) stress play an important role in pathogenesis AILI. Mesencephalic astrocyte-derived neurotrophic factor (MANF) a newly identified 18-kDa soluble protein, whose expression secretion are stimulated by ER stress. To investigate myeloid cell MANF AILI, we assayed serum samples from AILI model mice...
Background/Aims: The Wnt/β-catenin signaling pathway has been reported to play an important role in liver fibrosis.This study was designed investigate whether mesodermspecific transcript homologue (Mest), a strong negative regulator of signaling, could inhibit fibrosis.Methods: pcDNA-Mest transfected into hepatic stellate cells (HSCs) and rats.Rats were randomly divided four groups: normal group (normal saline), treatment (pcD-NA-Mest+CCl 4 ), control (pcDNA-neo+CCl model saline+CCl...