A5091322217- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- IL-33, ST2, and ILC Pathways
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Eosinophilic Esophagitis
- Process Optimization and Integration
- Pharmacological Effects of Natural Compounds
- T-cell and B-cell Immunology
- Animal health and immunology
- Osteoarthritis Treatment and Mechanisms
- Birth, Development, and Health
- Biomedical Research and Pathophysiology
- Vagus Nerve Stimulation Research
- Fluorine in Organic Chemistry
- Spinal Dysraphism and Malformations
- Water Quality Monitoring Technologies
- Fusion materials and technologies
- Gut microbiota and health
- Endometriosis Research and Treatment
- Preterm Birth and Chorioamnionitis
Anhui Medical University
2018-2025
Tongji University
2025
Shanghai Pulmonary Hospital
2025
University of Science and Technology Liaoning
2025
Wenzhou Medical University
2024
Chinese Academy of Sciences
2015-2022
National Space Science Center
2022
The University of Texas Health Science Center at Houston
2022
Shanghai Institute of Organic Chemistry
2018
University of Chinese Academy of Sciences
2018
Abstract Hepatitis B virus (HBV) persistence is a fundamental process in chronic HBV infection and key factor all related liver diseases; however, the mechanisms have yet to be elucidated. We studied role of TLR2 using well-established HBV-carrier mouse model generated by hydrodynamically injecting phospho–adeno-associated virus/HBV1.2 plasmid into mice. found that genetic deficiency improves elimination, whereas activating led more stable persistence, suggesting activation critical...
Background: Chronic cadmium exposure can induce the onset and progression of hepatorenal fibrosis; however, its molecular basis is unclear. Insulin-like growth factor-binding protein 7 (IGFBP7) not only a biomarker acute kidney injury (AKI), but also plays functional role in promoting inflammation. Abnormal repair AKI causes fibrosis chronic disease. IGFBP7 has been reported as more sensitive for liver fibrosis. However, requires further investigation. Methods: global conditional knockout...
Significance We present a unique study of liver-induced systemic tolerance using an intact virus, other than single protein component-induced liver-persistent model. Liver-educated regulatory cells migrate into peripheral sites and mediate the tolerance. Kupffer induce generation type 1-like in IL-10–dependent manner. A possible role suppressing germinal center formation via secreting IL-10 is demonstrated. observed that “regulatory cell-based” tolerizing mechanism, rather “clonal deletion”...
Abstract Acetaminophen (APAP)-induced liver injury (AILI) is the most frequent cause of acute failure; but underlying mechanisms still remain obscure. Macrophages and endoplasmic reticulum (ER) stress play an important role in pathogenesis AILI. Mesencephalic astrocyte-derived neurotrophic factor (MANF) a newly identified 18-kDa soluble protein, whose expression secretion are stimulated by ER stress. To investigate myeloid cell MANF AILI, we assayed serum samples from AILI model mice...
Background and Aims: A better understanding of the underlying mechanism acetaminophen (APAP)‐induced liver injury (AILI) remains an important endeavor to develop therapeutic approaches. Eosinophils have been detected in biopsies patients with APAP overdose. We recently demonstrated a profound protective role eosinophils against AILI; however, molecular had not elucidated. Approach Results: In agreement our previous data from experiments using genetic deletion eosinophils, we found that...
In order to address with the defects of poor cooling capacity and uniformity rail air-quenching technology, supersonic profiling nozzle (SP nozzle) was designed improve through jet structure head. Numerical simulation method combined experimental were used study heat transfer characteristics SP on rail. The results showed that air-cooled quenching at a pressure 0.4 MPa increased by 23.96%, 15.35% 31.69%, 36.82%, 46.98% 22.19% over existing circular normal nozzle, respectively. A segmented...
Background and Aims: Insufficient liver regeneration causes post‐hepatectomy failure small‐for‐size syndrome. Identifying therapeutic targets to enhance hepatic regenerative capacity remains urgent. Recently, increased IL‐33 was observed in patients undergoing resection mice after partial hepatectomy (PHx). The present study aims investigate the role of PHx elucidate its underlying mechanisms. Approach Results: We performed −/− , suppression tumorigenicity 2 (ST2) wild‐type control mice,...
Background & AimsLiver contains high frequency of group 1 innate lymphoid cells (ILC), which are composed comparable number type ILC (ILC1) and natural killer (NK) in steady state. Little is known about whether how the interaction between ILC1 NK affects development alcoholic liver disease.MethodsA mouse model chronic alcohol abuse plus single-binge (Gao-Binge model) was established. The levels alanine aminotransferase/aspartate aminotransferase, hepatic lipid, inflammatory cytokines or...
Abstract Background Interleukin‐15 ( IL ‐15) is a pleiotropic cytokine known to modulate both innate and adaptive immunity. It suggested that ‐15 may play an important role in the regulation of immune response hepatitis B virus HBV ). Aims We investigated whether could . Methods A mouse model for tolerance was established by hydrodynamical injection pAAV / 1.2 plasmid into C 57 BL /6 mice. This ‐carrier simultaneously hydrodynamically injected with either ‐15‐expression pLIVE ‐ or mock...
BACKGROUND:Alcoholic liver disease (ALD), an important cause of acute or chronic injury, results from binge drinking long-term alcohol consumption. To date, there is no well-established mouse model with a comprehensive metabolic profile that mimics ALD in humans. This study aimed to explore the differential pathways and related metabolites model. MATERIAL AND METHODS:A C57BL/6J was induced by feeding for 10 days plus feeding. The metabolomic profiles detected through ultra-high-pressure...
This study aims to investigate the number changes and clinical significance of peripheral blood T lymphocyte subsets NK (natural killer) cells in unexplained recurrent spontaneous abortion (URSA) patients before after abortion, as well successful pregnancy.Thirty-nine URSA (URSA-abortion group), among who 22 were followed up until final parturition (URSA-pregnancy 31 normal-pregnancy (NP) cases 25 normal non-pregnancy (NNP) control which lymphocytes subsets, B cells, assessed flow...
Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, causing a major risk of liver disease and hepatocellular carcinoma (HCC). Many mouse models have been tried to establish HBV infection through injection with various HBV-containing plasmids. However, it is not well understood that different plasmids, all which contain the similar genome, even same plasmids dose, results in opposite immune responses toward HBV. In this study, we investigated role plasmid...
Despite the fact that both Hepatitis B virus (HBV) infection and excessive alcohol consumption represent health problems worldwide, mechanism by which affected progression of HBV-associated liver disease are not completely understood. Therefore, we studied how affects development HBV role T cells NK in antiviral response. Mononuclear (MNCs) derived from HBV-carrier mice wild type (WT) were characterized for phenotype flow cytometry, antigen gene expression detected Radio Immunoassay (RIA),...
Background: Alcohol-associated liver disease (ALD) is a major clinical issue characterized by progressive stages, including hepatic steatosis, fibrosis, cirrhosis, and HCC. Patients with long-term chronic alcoholism often present gut microbiota dysbiosis reduced plasma levels of vitamin B 6 . This study aimed to verify that disruption in ALD significantly contributes vivo production investigate the role this reduction pathogenesis ALD. Methods: The was investigated utilizing Gao-binge mouse...
The development and immune recognition of natural killer (NK) cell are regulated critically by major histocompatibility complex (MHC) class I molecules. However, it remains unclear whether the function NK cells is MHC II To test this, we monitored development, phenotype using deficient (H2−/−) mice. numbers keep unaltered in H2−/− mice, compared with those wide type (H2+/+) A part Ly49 family receptors on down-regulated both mRNA protein expression absence Furthermore, obtained from mice...