A5103189019- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Acupuncture Treatment Research Studies
- Gut microbiota and health
- Esophageal and GI Pathology
- Vagus Nerve Stimulation Research
- Infant Health and Development
- Wireless Body Area Networks
- Potassium and Related Disorders
- Cardiovascular Function and Risk Factors
- Music Therapy and Health
- Dermatology and Skin Diseases
- EEG and Brain-Computer Interfaces
- Vascular anomalies and interventions
- Cardiac, Anesthesia and Surgical Outcomes
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- Abdominal Surgery and Complications
- Neural dynamics and brain function
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Respiratory and Cough-Related Research
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2015-2024
Zhejiang Sci-Tech University
2024
Functional dyspepsia is of high prevalence with little treatment options. The aim this study was to develop a new method using self-management transcutaneous electroacupuncture (TEA) for functional (FD). Twenty-eight patients FD were enrolled and underwent crossover clinical trial 2-week TEA at ST36 PC6 sham-TEA nonacupuncture sham-points. Questionnaires used assess symptoms quality life. Physiological testing included gastric emptying electrogastrography. It found that (1) but not...
Objective We measured the fecal levels of short-chain fatty acids (SCFAs) in subjects with slow transit constipation (STC) and assessed correlation between SCFA disease severity as well quality life. Methods isolated supernatant from samples healthy STC levels. To assess life, we used Constipation Scoring System, Patient Assessment Symptoms, Quality Life questionnaires. Results 16 controls were enrolled. had lower levels, but difference was not statistically significant (475.85 ± 251.68 vs....
High-resolution manometry (HRM) has improved the accuracy of in detecting achalasia and helped distinguish between clinically relevant subtypes. This study investigated whether HRM metrics correlate with symptoms symptomatic outcomes peroral esophageal myotomy (POEM).Of 30 patients who were enrolled, 25 treated POEM, 12 underwent after 3 months. All completed Eckardt score questionnaires, those POEM followed up for about 6 Pearson correlation was used to assess relationship outcomes.The...
Little data exists about esophageal body dysmotility and reflux patterns in refractory gastroesophageal disease (RGERD) patients off therapy. We aimed to evaluate effects of on parameters RGERD by combining impedance-pH monitoring high-resolution manometry (HRM).We retrospectively reviewed the HRM metrics with symptoms. Impedance-pH manometric were compared between 2 groups: ineffective motility (IEM) normal motility.Forty-eight (30 males, mean age 54.5 years) included (16 erosive...
Esophageal mean nocturnal baseline impedance (MNBI) levels and post-reflux swallow-induced peristaltic wave (PSPW) index could increase the diagnostic value of 24-hour multichannel intraluminal pH monitoring in patients with gastroesophageal reflux disease. This study aims to compare MNBI PSPW no evidence erosive disease.Impedance-pH tracings from 70 patients, 50 non-erosive disease (NERD) 20 functional heartburn (FH), were reviewed. According proton pump inhibitors (PPI) treatment response,...
Abstract To investigate the efficacy of sacral nerve stimulation (SNS) on growth factor (NGF) mediated visceral sensitivity in normal rat and hypersensitivity model rats. 120 male newborn rats were randomly divided into 6 groups: group A was group; B ~ F all sensitized with acetic acid enema grouped again. Group c2 given NGF antagonist, d2 agonist, e2 PI3K inhibitor, f2 PLC‐γ inhibitor. After treatment, expression NGF, TrKA, PI3K, AKT, PLC‐γ, NF‐κB, TRPV1, pTRPV1 intracellular Ca 2+ content...
Gastro-esophageal reflux disease (GERD) is a common in gastroenterology outpatients. However, some patients with typical symptoms does not satisfy diagnostic criteria. This study was to explore the value of adjunctive evidence from multichannel intraluminal impedance-pH (MII-pH) monitoring and esophageal high-resolution manometry (HRM) inconclusive GERD acid exposure time (AET) 4-6%.Endoscopy, MII-pH HRM were retrospectively analyzed consecutive tertiary hospital 2013 2019. Patients...
Numerous studies have investigated utility of esophageal intraluminal baseline impedance levels (BILs) in gastroesophageal reflux disease (GERD). However, effect BILs refractory GERD (RGERD) has not been well investigated. The aim this study is to evaluate role RGERD patients. Total 62 subjects with symptoms underwent 24-hour impedance-pH monitoring and gastroendoscopy. Distal acid type were significantly lower than those nonacid functional heartburn (FH) group. esophagitis (RE) patients...
Background/Aims: The incidence of reflux esophagitis (RE) has a striking predominance in males. Conversely, non-erosive disease (NERD) is more common females. This imbalance gastroesophageal (GERD) implies sex-related differences its pathogenesis. However, limited studies have analyzed the sex-based pH parameters and esophageal impedance GERD patients. Methods: study evaluated pathogenesis by comparing episodes, mean nocturnal baseline (MNBI) values, post-reflux swallow-induced peristaltic...
<title>Abstract</title> Estrogen and oxidative stress are associated with reflux esophagitis (RE) its underlying complications. It has been reported that 17β-estradiol (E2) protects the esophageal mucosa via antioxidant properties. Sirtuin-3 (SIRT3) is a member of Sirtuin family against diseases related to stress. We hypothesized E2 epithelial injury induced by noxious refluxes activating SIRT3 signaling pathway. In human cells (Het-1A), acidic bile salts (BA/A) at 200 µM concentration...
Objective To investigate the correlation between clinical symptoms of patients with achalasia cardia (AC) and high-resolution manometry (HRM) parameters. Methods The data 30 AC were retrospectively analyzed. The severe degree was evaluated by Eckardt score questionnaires, motility esophagus assessed HRM parameters.According to Chicago classification, divided into three types. Mann-Whitney U test performed for non normal distribution quantitative comparison. Spearman used analyze...