A5100342075- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gut microbiota and health
- Esophageal and GI Pathology
- Congenital gastrointestinal and neural anomalies
- Music Therapy and Health
- Acupuncture Treatment Research Studies
- Pelvic floor disorders treatments
- Diet and metabolism studies
- Infant Health and Development
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Dysphagia Assessment and Management
- Growth Hormone and Insulin-like Growth Factors
- Ion channel regulation and function
- Ion Channels and Receptors
- Metabolomics and Mass Spectrometry Studies
- Esophageal Cancer Research and Treatment
- Phonocardiography and Auscultation Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Gastrointestinal Bleeding Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Nanjing University of Chinese Medicine
2016-2025
Tzu Chi University
2021-2024
Hangzhou Normal University
2022-2024
China Medical University
2021-2024
Fujian Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Changzhou Third People's Hospital
2024
Sun Yat-sen Memorial Hospital
2019-2024
Introduction: The expression, mechanisms of regulation, and functional impact INHBA (activin A) in lung adenocarcinoma (AD) have not been fully elucidated. Methods: expression was examined 96 samples (86 ADs, 10 normal lung) using oligonucleotide microarrays 187 (164 6 bronchioalveolar carcinomas, 17 immunohistochemistry. proliferation AD cell lines H460 SKLU1 with WST-1 assays after treatment recombinant activin A, follistatin, INHBA-targeting small-interfering RNA. Cells were also treated...
BACKGROUND Steroidogenic factor 1 (SF1/AdBP4/FTZF1, NR5A1) is a nuclear receptor transcription that plays key role in regulating adrenal and gonadal development, steroidogenesis reproduction. Recently, haploinsufficiency of SF1 has been described several 46,XY individuals with mild dysgenesis impaired androgenization, but normal function, suggesting dosage-sensitive or domain-specific effects action are important human testicular development function. Our objective was to investigate whether...
A LC−MS based method, which utilizes both reversed-performance (RP) chromatography and hydrophilic interaction (HILIC) separations, has been carried out in conjunction with multivariate data analysis to discriminate the global serum profiles of renal cell carcinoma (RCC) patients healthy controls. The HILIC was found necessary for a comprehensive metabonomic profiling as well RP separation. feasibility using metabonomics diagnosis staging RCC evaluated. One-hundred percent sensitivity...
Cell-cell communication via Wnt ligands is necessary in regulating embryonic development and has been implicated CKD. Because are ubiquitously expressed, the exact cellular source of Wnts involved CKD remains undefined. To address this issue, we generated two conditional knockout mouse lines which Wntless (Wls), a dedicated cargo receptor that obligatory for secretion, was selectively ablated tubular epithelial cells or interstitial fibroblasts. Blockade secretion by genetic deletion Wls...
Treatment of functional dyspepsia is difficult due to various pathophysiological factors. The proposed method transcutaneous auricular vagal nerve stimulation improves symptoms both and depression/anxiety, gastric functions (accommodation slow waves), possibly mediated via the enhancement efferent activity. This noninvasive easy-to-implement neuromodulation will be well received by patients healthcare providers.
Probiotic supplements were shown to improve cognitive function in Alzheimer's disease (AD) patients. However, it is still unclear whether this applies older individuals with mild impairment (MCI). We aimed explore the effects of probiotic supplementation on multiple neural behaviors adults MCI. Forty-two MCI patients (age > 60 years) randomly divided into two groups and consumed either probiotics (n=21) or placebo for 12 weeks. Various scale scores, gut microbiota measures serological...
To investigate the relationship between gender and symptomatology, psychological factors, quality of life (QOL) in irritable bowel syndrome (IBS).The diagnosis IBS was made on basis Rome III Criteria. A physician obtained demographic symptom data, Zung Self-Rated Anxiety Depression Scale scores (SAS/SDS), IBS-specific quality-of-life ratings (IBS-QOL).Of 4015 patients approached, 452 were diagnosed with IBS. Age ranged from 14 to 79 years (44.05 ± 14.89 years) male female ratio 1 : 1.3. The...
Abstract Recent research suggested that taking a high‐fat diet (HFD) may lead to gut microbiota imbalance and colon tissue damage. This would increased intestinal permeability consequent constant circulation of low‐grade inflammatory cytokines. Spirulina platensis can protect against HFD‐induced metabolic inflammation stimulate the growth beneficial bacteria in vitro stool cultures. However, it is unknown whether this effect acts on tissues. In study, rats were fed with 3% S for 14 weeks. We...
Background Immune-checkpoint inhibitors (ICIs) remain ineffective in a large group of non-small cell lung cancer (NSCLC) patients. Mucosal-associated invariant T (MAIT) cells, population unconventional innate-like lymphocytes abundant the human body, play important roles malignancies. Little is known about immune characteristics MAIT cells NSCLC and correlation with prognosis response rate ICIs treatment. Methods To investigate distribution, activation status, function patients their...
Gastrointestinal symptoms are more prevalent in children with autism spectrum disorder (ASD) than typically developing (TD) children. Constipation is a significant gastrointestinal comorbidity of ASD, but the associations among constipated (C-ASD), microbiota and short-chain fatty acids (SCFAs) still debated. We enrolled 80 children, divided into C-ASD group (n = 40) TD 40). In this study, an integrated 16S rRNA gene sequencing gas chromatography-mass spectrometry-based metabolomics approach...
The A-type potassium channel subunit Kv4.2 influences hippocampal function through regulation of dendritic excitability, and changes in surface expression alter synaptic plasticity. Recent data from our laboratory demonstrate that EGFP (enhanced green fluorescent protein)-tagged channels located spines are internalized an activity-dependent manner after stimulation during chemically induced long-term potentiation. However, the molecular trigger for internalization remains unknown. Here we...
The aims of this study were to investigate the effects and possible mechanisms transcutaneous neuromodulation (TN) in patients with chronic constipation. Twelve recruited. treatment consisted 2‐week TN sham‐TN which was performed a crossover design. Bowel habit diary, Patient Assessment Constipation Symptom (PAC‐SYM), Quality Life (PAC‐QOL), anorectal motility evaluated. Electrocardiogram recorded for assessment autonomic function during acute therapy. It found that (1) improved frequency...
Functional dyspepsia is of high prevalence with little treatment options. The aim this study was to develop a new method using self-management transcutaneous electroacupuncture (TEA) for functional (FD). Twenty-eight patients FD were enrolled and underwent crossover clinical trial 2-week TEA at ST36 PC6 sham-TEA nonacupuncture sham-points. Questionnaires used assess symptoms quality life. Physiological testing included gastric emptying electrogastrography. It found that (1) but not...
Abstract The decrease of neurotransmitter dopamine (DA) levels in the intestine is closely related to development inflammatory bowel disease (IBD). However, functional relevance and underlying mechanistic basis effects DA signaling on IBD remains unclear. Here, we observed that DRD5 receptor highly expressed colonic macrophages, deficiency DA-DRD5 exacerbated experimental colitis. Moreover, can inhibit M1 by negatively regulating NF-κB but promote M2 macrophage polarization through...
Numerous studies have indicated a connection between psychiatric symptoms, specifically anxiety and depression, gastroesophageal reflux. However, the precise nature of link severity reflux disease depression remains uncertain. Here, we gathered 24-h pH monitoring data baseline patient information from cohort 518 individuals. Additionally, evaluated their psychological well-being using Hospital Anxiety Depression Scale. The relationship characteristics varying degrees anxiety, (GERD) was...
The rapid emergence of single-cell data has facilitated the study many different biological conditions at cellular level. Cluster analysis been widely applied to identify cell types, capturing essential patterns original in a much more concise form. One challenge cluster cells is matching clusters extracted from datasets origins or conditions. Many existing algorithms cannot recognize new types present only one two samples when establishing correspondence between obtained samples....
To assess the prognostic significance of plasma fibrinogen（FIB） levels in patients diffuse large B-cell lymphoma(DLBCL). We retrospectively analyzed 203 newly diagnosed with DLBCL who met study requirements from November 2016 to May 2024. Based on receiver operating characteristic (ROC) curve analysis FIB during diagnosis, critical value was determined, and were divided into high low groups. The clinical characteristics relevant laboratory indicators two groups compared. impact overall...
The visual quality assessment of rural landscapes is vital for quantifying ecological ser-vice functions and cultural heritage, yet traditional indicators fail to capture emotional cognitive experiences. Therefore, this study introduces a meth-od assessing landscape that integrates multi-modal emotion classification model enhance the quantitative drive towards sustainability. experiment selected four types from three representative villages in Dalian, China, collecting physiological data...
Background: Sleep disturbance is a common symptom in CC patients, and it positively related to greater somatic psychiatric symptoms. Methods: The participants were 126 adult outpatients with CC. measures were: constipation—Constipation Scoring System (CSS) Patient Assessment of Constipation-Symptoms (PAC-SYM); sleep—Pittsburgh Quality Index (PSQI); anxiety—General Anxiety Disorder-7 (GAD-7); depression—Patient Health Questionnaire-9 (PHQ-9); QOL—Patient Constipation Life (PAC-QOL) SF-36....