A5027131842- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Ureteral procedures and complications
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Kidney Stones and Urolithiasis Treatments
Nanjing Medical University
2022-2025
Jiangsu Province Hospital
2022-2025
Background Immune-checkpoint inhibitors (ICIs) remain ineffective in a large group of non-small cell lung cancer (NSCLC) patients. Mucosal-associated invariant T (MAIT) cells, population unconventional innate-like lymphocytes abundant the human body, play important roles malignancies. Little is known about immune characteristics MAIT cells NSCLC and correlation with prognosis response rate ICIs treatment. Methods To investigate distribution, activation status, function patients their...
Abstract Clear cell renal carcinoma (ccRCC) represents the most common subtype of carcinoma, accounting for approximately 70% cases. Notably, majority ccRCC tumors are surrounded by a prominent pseudocapsule tissue, highlighting its potential diagnostic, prognostic, and therapeutic relevance. To comprehensively understand implications pseudocapsules in ccRCC, we constructed an extensive multi-omics atlas. The cohort included single-cell RNA sequencing, spatial transcriptomics, proteomics,...
The incidence of prostate cancer is increasing, and its poor prognosis associated with metadherin overexpression; however, molecular mechanisms are unclear. This study used Western blot, quantitative real-time polymerase chain reaction, immunofluorescence, tumorigenicity assays to investigate epithelial-mesenchymal transition in cancer. We found that was highly expressed tissues, especially PC-3 cells. Metadherin overexpression promoted t tumor growth. Bioinformatics analysis revealed...