A5101778477- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Silk-based biomaterials and applications
- Renal cell carcinoma treatment
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Invertebrate Immune Response Mechanisms
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Cellular transport and secretion
- Ovarian cancer diagnosis and treatment
- Mycobacterium research and diagnosis
Nanjing Medical University
2022-2025
Jiangsu Province Hospital
2024-2025
Soochow University
2024
Southeast University
2023
Anhui Provincial Children's Hospital
2023
Second Affiliated Hospital of Nanjing Medical University
2022
Abstract Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system, with clear renal (ccRCC) being most prevalent pathological subtype. Metastasis observed in 20-30% patients at initial diagnosis, and 20% cases develop metastasis even after surgery, resulting poor prognosis due to insensitivity radiotherapy chemotherapy. Early accurate diagnosis critical improving outcomes survival rates. However, specific humoral markers for non-invasive early screening RCC are currently...
Abstract Cuproptosis, a novel cellular demise pathway linked to copper homeostasis and ionophores, offers promising therapeutic avenues across diverse human ailments. However, the effectiveness of ionophores in cancer treatment is not that satisfactory. Tyrosine kinase inhibitors (TKIs) have revolutionized approach combating various types by regulating different cell death manners. In this research, we identified EGFR-TKIs MEK-TKIs significantly sensitized cuproptosis. Our investigation...
Abstract Clear cell renal carcinoma (ccRCC) represents the most common subtype of carcinoma, accounting for approximately 70% cases. Notably, majority ccRCC tumors are surrounded by a prominent pseudocapsule tissue, highlighting its potential diagnostic, prognostic, and therapeutic relevance. To comprehensively understand implications pseudocapsules in ccRCC, we constructed an extensive multi-omics atlas. The cohort included single-cell RNA sequencing, spatial transcriptomics, proteomics,...
Recent research emphasised the indispensable role of histone lactylation in activation hepatic stellate cells. The VHL mutation is extremely common clear cell renal carcinoma, which normally causes a metabolic shift cancer cells and increases lactate production, eventually creating lactate-enriched tumour microenvironment. Cancer-associated fibroblasts (CAFs) promote progression, also vital carcinoma. Therefore, this study investigated CAFs its impact on patient survival. Multiomics...
Recent research has demonstrated the diverse relationship between tumour metabolism and microenvironment (TME), for example, abnormal serine metabolism. This study investigated role of in papillary renal cell carcinoma (pRCC) focusing on prognostic value regulatory mechanisms. Gene expression profiles clinical data patients with pRCC were obtained from The Cancer Genome Atlas (TCGA) database Expression Omnibus (GEO) database. Kaplan-Meier curves used survival analysis consensus clustering...
Developmental remodeling of neurite is crucial for the accurate wiring neural circuits in developing nervous system both vertebrates and invertebrates, may also contribute to pathogenesis neuropsychiatric disorders, instance, autism, Alzheimer’s disease (AD), schizophrenia. However, molecular underpinnings underlying developmental are still not fully understood. Here, we have identified DnaJ-like-2 (Droj2), orthologous human DNAJA1 DNAJA4 that predicted be involved protein refolding, as a...
ABSTRACT Developmental neuronal pruning is a process by which neurons selectively remove excessive or unnecessary neurite without causing death. Importantly, this widely used for the refinement of neural circuits in both vertebrates and invertebrates, may also contribute to pathogenesis neuropsychiatric disorders, such as autism schizophrenia. In peripheral nervous system (PNS), class IV dendritic arborization (da) sensory Drosophila, dendrites losing their somas axons, while axons mushroom...
<title>Abstract</title> Background High grade serous ovarian cancer (HGSOC) had high lethality due to its relapse rate and acquired drug resistance. The tumor immune microenvironment (TIME) of HGSOC was heterogeneous, mostly cold. We aimed build the bridge between platinum-resistance related signatures patient overall survival (OS). Methods RNA sequencing data from GSE160626 used for extraction genes. TCGA-OV cohort were fitted into 101 kinds machine learning methods, validation included...
Although vaccines have been developed, mutations of SARS-CoV-2, especially the dominant B.1.617.2 (delta) and B.1.529 (omicron) strains with more than 30 on their spike protein, caused a significant decline in prophylaxis, calling for need drug improvement. Antibodies are drugs preferentially used infectious diseases easy to get from immunized organisms. The current study combined molecular modeling single memory B cell sequencing assess candidate sequences before experiments, providing...
Chimeric antigen receptor-modified T (CAR-T) cells have brought a major breakthrough in tumor immunotherapy. As research continues to develop, CAR-T therapies shown certain limitations, such as graft-versus-host reaction and the long time required generate cells. Natural killer (NK) cells, first line of defense against pathogens cancer belong innate immune system advantage being able replace can be used prepare engineered chimeric NK (CAR-NK) The biological characteristics CAR-NK their...