A5084971221- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Ocular Infections and Treatments
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Urologic and reproductive health conditions
- Barrier Structure and Function Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Corneal surgery and disorders
- Erythrocyte Function and Pathophysiology
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Bone Metabolism and Diseases
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Blood properties and coagulation
- Medicinal plant effects and applications
- Workplace Violence and Bullying
- Fibroblast Growth Factor Research
Anhui Provincial Children's Hospital
2016-2025
First Affiliated Hospital of Jinan University
2009-2025
Jinan University
2025
Fujian Medical University
2025
Xiamen University
2025
Nanjing Drum Tower Hospital
2024
Nanjing Medical University
2024
Traditional Chinese Medicine Hospital of Kunshan
2024
Shanghai University of Traditional Chinese Medicine
2024
Harbin Medical University
2004-2021
Circular RNAs (circRNAs) are a class of non-coding RNAs. They have been proved to be critically involved in tumorigenesis and progression malignancies through competing endogenous RNA (ceRNA) mechanism. Nevertheless, the exploration between circRNAs pathogenesis breast cancer (BC) is limited. Previously, circ_0005230 was identified upregulated BC tissues screened by circRNA microarray. In present study, we aimed investigate expression pattern, functional role, mechanism BC.qRT-PCR conducted...
Several studies have shown that internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) can result in the failure leukemia treatment and contribute to a poor prognosis. However, role overexpression FLT3 remains be fully elucidated. By mining public database, present study first identified expression was markedly higher, compared with other types tumor cell lines, indicating is important leukemia. In leukemia, found significantly upregulated acute myeloid lymphoblastic high...
Arsenic combined with all-trans retinoic acid (ATRA) is the standard of care for adult acute promyelocytic leukemia (APL). However, safety and effectiveness this treatment in pediatric patients APL have not been reported on basis larger sample sizes.We conducted a multicenter trial at 38 hospitals China. Patients newly diagnosed were stratified into two risk groups according to baseline WBC count FLT3-ITD mutation. ATRA plus arsenic trioxide or oral without chemotherapy administered...
The study's objectives were to: 1) use social support theory to examine factors influencing healthcare workers' opinions about workplace violence (WPV) prevention strategies, and 2) determine the types of that general practitioners (GPs) nurses sought expected after WPV exposure. A cross-sectional survey was used assess a sample 448 GPs 412 from 90 township hospitals located in Heilongjiang province, China. Results revealed workers exposed physical, psychological or both had strong opinion...
Objective: To investigate the correlation between expression of immunohistochemical marker cytokeratin (CK)-19 and clinical characteristics prognosis dual-phenotype hepatocellular carcinoma (DPHCC). Methods: The data patients diagnosed with (HCC) who underwent surgical resection were collected. DPHCC cases screened by immunohistochemistry, followed up, grouped. CK-19 pathological was analyzed statistical methods. enumeration compared using χ2 test or Fisher's exact probability method groups....
To analyze two families with inherited dysfibrinogenemia, and explore the molecular pathogenic mechanisms. The coagulation indexes of probands their family members were detected. FGA, FGB, FGG exons flanking sequences amplified by PCR, mutation sites identified sequencing. SIFT, PolyPhen2, LRT, ReVe, MutationTaster, phyloP, phastCons bioinformatics software used to predict functional impact sites. Protein structure amino acid conservation analysis variant conducted using PyMOL Clustal X...
To examine the medical students' awareness of laparoscopic surgery as well assess perceived importance simulation training, and its impact on confidence, career aspirations, proficiency, spatial skills, physical tolerance. Descriptive comparative study using pre- post-training assessments. Simulation training sessions centred techniques. Medical students in year three (n = 49) participated sessions. Before 85.7% were unaware laparoscopy, with females being less familiar than males (96.3% vs....
Ganoderma lucidum, within the Polyporaceae family of Basidiomycota, is a popular traditional remedy medicine used in Asia to promote health and longevity. Compounds extracted from G. lucidum have revealed anticancer, antioxidant liver protective effects. has been associated with prostate cancer cells. extracts contain numerous bioactive components; however, exact functional monomer unknown role triterpenes (GLT) remain obscure. The present study investigated effects GLT on cell viability,...
Objective. To investigate the hemostatic capability of mono- and bipolar transurethral resection prostate (TURP) by comparing microvessel diameter hyperplastic with coagulation depth achieved TURP. Material methods. The diameters 22 tissues obtained from open surgery were measured using a microscope. Thirty prostatic chips harvested monopolar TURP 30 sectioned, stained hematoxylin–eosin Results. minimum, maximum mean prostates 6.33, 139.04 21.19±12.80µm, respectively. depths 122.54±22.22...
Metastatic prostate cancer (PCa) remains incurable and fatal. Previous studies have proven that circulating tumor cells (CTCs) Ezrin are involved in PCa progression, metastasis, diagnosis, prognosis. Therefore, we aimed to investigate the roles of CTCs metastasis. The expression was measured by qRT–PCR immunohistochemical staining. migration invasion were evaluated. Additionally, clinical data from patients collected analyze potential PCa. results showed significantly upregulated tissues...
To compare the hemostatic properties of transurethral plasmakinetic resection prostate (PKRP) and standard (TURP) ex vivo, as perioperative bleeding is still regarded one major complications prostatectomy.Isolated normal saline (NS)-perfused porcine kidneys were used to determine efficacy PKRP TURP. The perfusion fluid loss was semiquantitatively measured in relation tissue ablation for two techniques specimens evaluated histologically.The group had a significantly smaller NS than TURP (4.16...
Upregulated gene 11 (URG11), a new upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, colon cancers. However, role URG11 prostate cancer remains yet to be elucidated. By determined expression human tissues, was found significantly positively correlated with severity cancer, compared that benign prostatic hyperplasia tissues. Further, mRNA protein levels were cell lines (DU145, PC3, LNCaP), epithelial...
Abstract The recurrence and metastasis is one of the major reasons for malignant tumor treatment failure. Melatonin, a naturally occuring hormone, could reduce various tumors. However, underlying molecular mechanisms melatonin on inhibition have not been fully elucidated. In present study, we explored impact migratory capability human gastric carcinoma cells using wound healing assay, further investigated if migration ability was embodied by relocating tight junction proteins zo‐1 occludin...
<i>Aim:</i> As capsular perforation is still regarded as one of complications transurethral prostatectomy, the aim this study was to compare properties in penetrating tissue plasmakinetic resection (PKRP) and prostate (TURP). <i>Methods:</i> Isolated normal saline-perfused porcine kidneys were used determine capsule PKRP TURP. We quantified compared time cutting through renal surface during different procedures. <i>Results:</i> The perforating capsula...
The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but functional underlying mechanism not studied clearly. We detected expression level SNHG12 PCa tissues matched adjacent normal that were collected from 85 patients. Then, colony formation assays, MTT experiments, flow cytometry used examine effect on proliferation, cell cycle distribution, apoptosis DU145 cells. Further, Transwell invasion assay was...
To explore the immune cell therapy for T lymphoma, we developed CD4-specific chimeric antigen receptor- (CAR-) engineered cells (CD4CART), and cytotoxic effects of CD4CART were determined in vitro vivo.