A5100354758- MicroRNA in disease regulation
- Genetic Mapping and Diversity in Plants and Animals
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antimicrobial Peptides and Activities
- Neuroscience and Neural Engineering
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- Epigenetics and DNA Methylation
- Atrial Fibrillation Management and Outcomes
- Dialysis and Renal Disease Management
- Cardiac Arrhythmias and Treatments
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Heat shock proteins research
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Cancer Immunotherapy and Biomarkers
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Disease Prevention
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Invertebrate Immune Response Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
Stanford University
2018-2025
Nanjing Medical University
2013-2025
Jiangsu Province Hospital
2025
Affiliated Hospital of Nantong University
2025
Second Affiliated Hospital of Nantong University
2025
Nantong University
2025
Cardiovascular Institute of the South
2018-2025
California Institute for Regenerative Medicine
2024
Chinese Academy of Sciences
2024
Beijing National Laboratory for Molecular Sciences
2024
Temporin-1CEa is an antimicrobial peptide isolated from the skin secretions of Chinese brown frog (Rana chensinensis). We have previously reported rapid and broad-spectrum anticancer activity temporin-1CEa in vitro. However, detailed mechanisms for temporin-1CEa-induced cancer cell death are still weakly understood. In present study, cytotoxicity on two human breast lines, MDA-MB-231 MCF-7, were investigated. The MTT assay LDH leakage indicated that one-hour incubation with led to a...
Background/aims The aim of this study was to generate and evaluate individualised post-therapeutic optical coherence tomography (OCT) images that could predict the short-term response antivascular endothelial growth factor therapy for typical neovascular age-related macular degeneration (nAMD) based on pretherapeutic using generative adversarial network (GAN). Methods A total 476 pairs OCT patients with nAMD were included in training set, while 50 tests set retrospectively, their...
Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop
<b><i>Background:</i></b> Renal fibrosis is a common outcome of nearly all kinds chronic kidney disease (CKD) and eventually progresses to end-stage renal disease. The identification an optimal biomarker replace the invasive biopsy will have important clinical implications. <b><i>Methods:</i></b> We isolated urinary exosomes from 50 participants examined exosomal protein content particle number in 38 CKD patients with different degrees 12...
NOTCH1 pathogenic variants are implicated in multiple types of congenital heart defects including hypoplastic left syndrome, where the ventricle is underdeveloped. It unknown how regulates human cardiac cell lineage determination and cardiomyocyte proliferation. In addition, mechanisms by which lead to ventricular hypoplasia syndrome remain elusive.CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 genome editing was utilized delete induced pluripotent stem cells....
Tubular epithelial cell apoptosis contributes to tubulointerstitial fibrosis but its regulation remained unclear. Here, in fibrotic kidney induced by unilateral ureteral obstruction (UUO), we demonstrated that miR-34a was markedly up-regulated spaces and microvesicles isolated from kidney. However, the increased not de novo synthesized proximal tubular cells fibroblasts after incubated with TGF-β1. MiR-34a culture media of TGF-β1 treated fibroblasts. These acted as a vector for delivery...
Helicobacter pylori (H. pylori) has characteristics of family cluster infection; however, its family-based infection status, related factors, and transmission pattern in central China, a high-risk area for H. gastric cancer, have not been evaluated. We investigated healthy households to understand patterns disease prevention.To investigate prevention.Blood samples survey questionnaires were collected from 282 families including 772 individuals. The recruited 10 selected communities the...
Viral infections represent a major threat to human health and the global economy; however, most of currently available antiviral drugs are not fully effective in restricting viral replication selecting for drug-resistant variants. Targeted protein degradation technologies promising strategies avoid or delay emergence drug resistance. Among degradation-based multi-specific approaches, proteolysis targeting chimera (PROTAC) is main strategy applied field. In this review we will introduce...
We have previously reported that temporin-1CEa, a cationic antimicrobial peptide, exerts preferential cytotoxicity toward cancer cells. However, the exact molecular mechanism for this cancer-selectivity is still largely unknown. Here, we found negatively charged phosphatidylserine (PS) expressed on cell surface serves as target temporin-1CEa. Our results indicate human A375 melanoma cells express 50-fold more PS than non-cancerous HaCaT The expression of in various lines closely correlated...
Regulated cell death (RCD) contributes to reshaping the tumor immune microenvironment and participating in progression of non-small lung cancer (NSCLC); however, related mechanisms have not been fully disclosed. Here, we identified 5 subclusters NSCLC based on consensus clustering 3429 RCD-associated genes TCGA database depicted genomic features landscape these clusters. Importantly, clusters provided insights into recognizing (TME) responses immunotherapy chemotherapy. Further, established...
BackgroundFibrosis is a heavy burden on the global healthcare system. Recently, an increasing number of studies have demonstrated that Extracellular vesicles play important role in intercellular communication under both physiological and pathological conditions. This study aimed to explore extracellular vesicles' fibrosis using bibliometric methods.MethodsOriginal articles reviews related were obtained from Web Science Core Collection database November 9, 2022. VOSviewer was used obtain...
Abstract The epithelial-mesenchymal transformation (EMT) process of alveolar epithelial cells is recognized as involved in the development pulmonary fibrosis. Recent evidence has shown that lipopolysaccharide (LPS)-induced aerobic glycolysis lung tissue and elevated lactate concentration are associated with pathogenesis sepsis-associated However, it uncertain whether LPS promotes fibrosis by promoting accumulation tissue, thereby initiating EMT process. We hypothesized monocarboxylate...
Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, promotes the cytotoxicity of genotoxic anticancer drug cisplatin, yet underlying mechanism remains poorly understood. Herein, we revealed that TSA at low concentration (1 μM) promoted cisplatin-induced activation caspase-3/6, which, in turn, increased level cleaved PARP1 and degraded lamin A&C, leading to more apoptosis G2/M phase arrest A549 cancer cells. Both ICP-MS ToF-SIMS measurements demonstrated significant increase...
Preeclampsia (PE) is a common hypertensive disease in women with pregnancy. With the development of bioinformatics, WGCNA was used to explore specific biomarkers provide therapy targets efficiently. All samples were obtained from gene expression omnibus (GEO), then we package named "WGCNA" construct scale-free co-expression network and modules related PE. Next, search tool for retrieval interacting genes database (STRING) adopted structure protein-protein interaction (PPI) hub module....