A5100322945- Reconstructive Surgery and Microvascular Techniques
- Extracellular vesicles in disease
- Reconstructive Facial Surgery Techniques
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- MicroRNA in disease regulation
- Facial Trauma and Fracture Management
- Facial Rejuvenation and Surgery Techniques
- Cervical and Thoracic Myelopathy
- RNA Interference and Gene Delivery
- Bone fractures and treatments
- Facial Nerve Paralysis Treatment and Research
- Spinal Hematomas and Complications
- Lymphoma Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Cancer-related molecular mechanisms research
- Congenital Diaphragmatic Hernia Studies
- Orthopedic Surgery and Rehabilitation
- Cancer, Lipids, and Metabolism
- Trauma Management and Diagnosis
- Cancer Diagnosis and Treatment
- Cancer-related gene regulation
Second Affiliated Hospital of Guangzhou Medical University
2022-2025
Guangzhou Medical University
2022-2025
Ningbo No.6 Hospital
2018-2025
Yanbian University Hospital
2025
Shihezi University
2025
Anhui University of Traditional Chinese Medicine
2025
Kunming Medical University
2015-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying mechanism unclear. In this study, we investigated effect amyloid precursor protein (APP) and β on mitochondrial dynamics in neurons. Confocal electron microscopic analysis demonstrated that ≈40% M17 cells overexpressing WT APP (APPwt cells) more than 80% APPswe mutant (APPswe displayed alterations morphology distribution. Specifically, mitochondria exhibited fragmented structure an abnormal distribution...
Abstract Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal injury (SCI), their mechanism action remains unclear. Methods We designed and performed this study determine whether exosomes attenuate the lesion size SCI by ameliorating neuronal induced a secondary inflammatory storm promoting neurite outgrowth. determined absolute levels all exosomal miRNAs investigated...
Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-inflammatory polarization of macrophages. However, possible therapeutic effect on SLE remains unexplored.Exosomes were isolated conditioned medium bone marrow-derived mesenchymal using ultrafiltration and size-exclusion chromatography identified by nanoparticle tracking analysis...
We subjected rats to either partial midcervical or complete upper thoracic spinal cord transections and examined whether combinatorial treatments support motor axonal regeneration into beyond the lesion. Subjects received cAMP injections brainstem reticular neurons stimulate their endogenous growth state, bone marrow stromal cell grafts in lesion sites provide permissive matrices for growth, brain-derived neurotrophic factor gradients distal of axons. Findings were compared with several...
<title>Abstract</title> Objective: To explore the relationship between preoperative nutritional index (PNI) and systemic immune inflammatory (SII) levels postoperative delirium (POD) in patients undergoing thoracoscopic surgery, risk factorsfor POD during surgery. Methods: This study selected 106 who underwent surgery under general anesthesia at a tertiary hospital. One day before Mini Mental State Evaluation Scale (MMSE) was used to evaluate cognitive function of surgical patients. The...
Abstract Context T helper (Th)17 cells are correlated with many human autoimmune disorders, including Graves disease, and may play key roles in the pathogenesis of orbitopathy (GO). Objective To study phenotype Th17 patients GO healthy subjects, investigate fibrosis adipogenesis orbital fibroblasts (OFs) modulated by interleukin (IL)-17A, determine interaction between OFs. Design/Setting/Participants Blood samples tissues from controls were collected. Main Outcome Measures We conducted...
Acute spinal cord injury (SCI) is a devastating result of neurological trauma with subsequent microenvironment dyshomeostasis that induces neurotoxic phenotype acquisition by astrocytes, exacerbating function impairment. Exosomes derived from human umbilical mesenchymal stem cells (hUCMSCs) have demonstrated essential therapeutic effects after central nervous system trauma. However, whether hUCMSC-derived exosomes exert on astrocytes to facilitate SCI recovery remains unclear. Additionally,...
The main objective of this study is to evaluate the influence exosomes derived from endothelial progenitor cells (EPC-Exo) on neointimal formation induced by balloon injury in rats. Furthermore, aims investigate potential EPC-Exo promote proliferation, migration, and anti-apoptotic effects vascular (VECs) vitro. underlying mechanisms responsible for these observed will also be thoroughly explored analyzed. Endothelial (EPCs) was isolated aseptically Sprague-Dawley (SD) rats cultured complete...
Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain, the treatment of IDD costly relatively ineffective. Dysregulation microRNAs (miRNAs) has been reported be involved in IDD. The purpose our study illustrate potential that miR-143-5p targeting eEF2 gene mediates Following establishment rat models, expression miR-143-5p, eEF2, Bcl-2, Bax, AMPK, mTOR, cyclinD, COL2, ACAN, DCN was detected. NP cells isolated from degenerative intervertebral (IVD)...
Corneal neovascularization (CoNV) is predominantly initiated by inflammatory processes, resulting in aberrant vascular proliferation and consequent visual impairment. Existing therapeutic interventions for CoNV demonstrate limited efficacy potential adverse reactions. Protein arginine methyltransferase 1 (PRMT1) associated with the regulation of inflammation M2 macrophage polarization. Nevertheless, precise mechanism which PRMT1 operates remains uncertain. This study explored impact...
Abstract Background Human umbilical cord mesenchymal stem cells-derived extracellular vesicles (hUCMSC-EVs) have potent immunomodulatory properties similar to parent cells. This study investigated the therapeutic effects and mechanisms of hUCMSC-EVs in an experimental lupus nephritis model. Methods The were isolated by using differential ultracentrifugation. In vivo, lupus-prone MRL/lpr mice investigated, treatment explored according abnormal T B cell responses among both spleen kidney....
Introduction: This study aimed to investigate the factors influencing medication adherence in community-dwelling Chinese older adults with hypertension. Design: Empirical research–quantitative; Cross-sectional Methods: A cross-sectional survey was conducted from September December 2021, which participants completed a self-administered questionnaire detailed their demographic information. The Morisky Medication Adherence Scale-8, Pittsburgh Sleep Quality Index, and 10-item Kessler...
<title>Abstract</title> Background Clear cell renal carcinoma (ccRCC) is a highly aggressive kidney cancer subtype with poor survival rates, particularly in metastatic cases. While proteomics and immune dysregulation are implicated ccRCC, the causal relationships between circulating proteins ccRCC remain poorly understood. This study investigates roles of pathogenesis identifies potential therapeutic targets. Methods We conducted two-sample Mendelian randomization (MR) analysis using...