A5070580525- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Pancreatic function and diabetes
- Corneal surgery and disorders
- Cancer Immunotherapy and Biomarkers
- Ocular Surface and Contact Lens
- Inflammation biomarkers and pathways
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- Retinal Imaging and Analysis
- AI in cancer detection
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Ocular Infections and Treatments
- Adenosine and Purinergic Signaling
Renmin Hospital of Wuhan University
2015-2025
Wuhan University
2015-2025
Kunming Medical University
2016-2024
Ann Arbor VA Medical Center
2023
University of Michigan–Ann Arbor
2011-2023
Xijing Hospital
2023
Air Force Medical University
2023
Central South University
2023
NYU Langone Health
2018-2023
The First Hospital of Changsha
2023
Abstract Myeloid-derived suppressor cells (MDSC) contribute to immune suppression in cancer, but the mechanisms through which they drive metastatic progression are not fully understood. In this study, we show how MDSC convey stem-like qualities breast cancer that coordinately help enable and escape. We found promoted tumor formation by enhancing cell properties as well suppressing T-cell activation. Mechanistic investigations indicated these effects relied upon cross-talk between STAT3 NOTCH...
Defect passivation has been demonstrated to be effective in improving the radiative recombination of charge carriers perovskites, and consequently, device performance resultant perovskite light-emitting diodes (LEDs). State-of-the-art useful agents LEDs are mostly organic chelating molecules that, however, simultaneously sacrifice charge-transport properties thermal stability emissive layers, thereby deteriorating performance, especially operational devices. We demonstrate that lithium...
Abstract Pancreatic cancer, one of the deadliest human malignancies, is associated with oncogenic Kras and most commonly preceded by precursor lesions known as pancreatic intraepithelial neoplasias (PanIN). PanIN formation accompanied establishment an immunotolerant microenvironment. However, immune contribution to initiation cancer currently poorly understood. Here, we genetically eliminate CD4+ T cells in iKras* mouse model context pancreatitis, determine functional role during mutant...
Endoplasmic reticulum (ER) stress, pyroptosis, and apoptosis are critical molecular events in the occurrence progress of renal ischemia reperfusion (I/R) injury. Naringenin (4 <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mo>′</a:mo> </a:math> ,5,7-trihydroxyflavanone) is one most widely consumed flavonoids with powerful antioxidant anti-inflammatory activities. However, whether naringenin able to relieve I/R injury corresponding mechanisms have not been fully clarified....
LBA4009 The full, final text of this abstract will be available in Part II the 2009 ASCO Annual Meeting Proceedings, distributed onsite at on May 30, 2009, and as a supplement to June 20, issue Journal Clinical Oncology. [Table: see text]
Hilar cholangiocarcinoma (CCA) is a difficult malignancy to treat surgically because of its anatomical location and frequent association with primary sclerosing cholangitis. Neoadjuvant chemoradiotherapy followed by liver transplantation in lymph node–negative patients has been advanced select transplant centers for the treatment unresectable disease. This approach most commonly used external-beam radiotherapy combination biliary brachytherapy 5-fluorouracil–based chemotherapy. Our center...
Hepatocellular Carcinoma (HCC) is one of the most lethal cancers with a high mortality and recurrence rate. Circulating tumor cell (CTC) detection offers various opportunities to advance early monitoring HCC tumors which crucial for improving patient outcome. We developed optimized novel Labyrinth microfluidic device efficiently isolate CTCs from peripheral blood patients. were identified in 88.1% patients over different stages. The CTC positivity rate was significantly higher more advanced...
Abstract Renal fibrosis is considered to be the ultimate pathway for various chronic kidney disease, with a complex etiology and great therapeutic challenges. Tripartite motif-containing (TRIM) family proteins have been shown involved in fibrotic diseases, but whether TRIM39 plays role renal remain unexplored. In this study, we investigated of its molecular mechanism. expression was analyzed patients’ specimens, HK-2 cells unilateral ureteral obstruction (UUO) mice were used functional...
Corneal neovascularization (CoNV) is predominantly initiated by inflammatory processes, resulting in aberrant vascular proliferation and consequent visual impairment. Existing therapeutic interventions for CoNV demonstrate limited efficacy potential adverse reactions. Protein arginine methyltransferase 1 (PRMT1) associated with the regulation of inflammation M2 macrophage polarization. Nevertheless, precise mechanism which PRMT1 operates remains uncertain. This study explored impact...
To explore the effects of puerarin on renal ischemia/reperfusion injury and possible mechanism. The experimental mice were injected with (50 or 100 mg/kg) per day equal sterile saline by intraperitoneal injection for one week, a I/R model was constructed. HK-2 cells incubated (1 uM 10 uM) before H/R model. Immunohistochemistry, immunocytochemistry, Western blot analysis used to detect protein associated apoptosis endoplasmic reticulum stress. Puerarin could improve function attenuate tissue...
Renal fibrosis is a critical progression of chronic kidney disease, and epithelial-to-mesenchymal transition (EMT) extracellular matrix(ECM) deposition are crucial pathologic change renal fibrosis, which still lacks effective treatment. In this study, it was found that cyanidin-3-O-glucoside (C3G) could inhibit EMT ECM activated by unilateral ureteral obstruction (UUO) transforming growth factor-β1 (TGF-β1) stimulation. Moreover, N-Myc downstream-regulated gene 2(NDRG2), involved in the...
Ecto-5'-nucleotidase (CD73), encoded by NT5E, is the major enzymatic source of extracellular adenosine. CD73 controls numerous pathophysiological responses and a potential disease target, but its regulation poorly understood. We examined NT5E alternative splicing. Genomic database analysis human transcripts led us to identify NT5E-2, novel splice variant that was expressed at low abundance in normal tissues significantly up-regulated cirrhosis hepatocellular carcinoma (HCC). NT5E-2 encodes...
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) has been found on human memory T lymphocytes. However, the roles of KLRG1 cells especially in tumor microenvironment have not fully understood. Our results showed expression significantly increased microenvironment. KLRG1+ exhibited poor proliferative capacity with decreased effector cytokine production. Meanwhile, expressed abundant pro-inflammatory cytokines and demonstrated high level Foxp3 expression. miRNA-101 higher CtBP2....
Histotripsy fractionates tissue through a mechanical, non-invasive ultrasonic ablation process that precisely controls acoustic cavitation while utilizing real-time ultrasound (US) imaging guidance. This study investigates the potential, feasibility and tumor volume reduction effects of histotripsy for liver cancer in subcutaneous vivo murine Hepatocellular Carcinoma (HCC) model. Hep3B tumors were generated right flanks 14 NSG 7 NOD-SCID mice. The mice grouped as follows: A (acute, with n=9...
ADAM17 (a disintegrin and metalloproteinase 17)/TACE (TNFα converting enzyme) has emerged as a potential therapeutic target in colorectal cancer (CRC) other cancers, due part to its role regulating various tumor cell surface proteins growth factors cytokines the microenvironment. The emergence of MEDI3622, highly potent specific antibody-based inhibitor, allowed testing concept that targeting may be an important new approach for CRC patients. We demonstrate MEDI3622 is efficacious on...
Background . Renal cell carcinoma (RCC) accounts for approximately 2–3% of malignant tumors in adults, while clear renal 70–85% kidney cancer cases, with an increasing incidence worldwide. G9a is the second histone methyltransferase found mammals, catalyzing lysine and methylation. It regulates gene transcription by methylation interacting factors to alter tightness histone‐DNA binding. The main purpose this study explore role mechanism carcinoma. Methods Firstly, we investigated expression...
Tumor immune responses have prognostic importance to hepatocellular carcinoma (HCC). Serum cytokines may differentiate HCC patients from cirrhotic or significance. IL-8 was elevated in 90 compared 180 controls, whereas IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-15, IL-17, IL-21, and VEGF were similar. predicted presence with an area under the receiver-operator curve (ROC) of 0.68. highest had worse survival. Multivariate analysis showed that high (HR 2.15; 95%CI:1.21-3.74) stage...
Background: Although previous studies of sleep-related behaviors in relation to primary open-angle glaucoma (POAG) have been noted, the causal relationship remains unclear. The purpose our present study was investigate relationships genetically predicted sleep traits with POAG using a two-sample bidirectional Mendelian randomization (MR) method. Methods: Summary-level data collected from publicly available genome-wide association (GWAS) European decent were applied for MR analysis. After...
Corneal neovascularization (CoNV) can cause abnormal blood vessels to grow in the transparent cornea, leading various sight-threatening eye diseases. MicroRNAs are known play essential roles regulation of numerous biological functions. We try clarify role a specific microRNA, miR‑497, which has been shown regulate growth tumor cells and angiogenesis on basis available data. However, association between miR-497 vascularized cornea remains unclear. Therefore, it is urgently needed understand...