A5017355711- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Venous Thromboembolism Diagnosis and Management
- Microbial Inactivation Methods
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microfluidic and Bio-sensing Technologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Diagnosis and Treatment of Venous Diseases
- Advanced MRI Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Radiotherapy Techniques
- Ultrasonics and Acoustic Wave Propagation
- Liver Disease Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Fluid Dynamics and Mixing
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Prostate Cancer Diagnosis and Treatment
- Electrical and Bioimpedance Tomography
- Optical Coherence Tomography Applications
University of Michigan
2016-2025
Klinikum Braunschweig
2024
University Hospital Magdeburg
2024
University of Kansas Medical Center
2024
Baptist Hospital of Miami
2024
Taizhou People's Hospital
2017-2024
Nanjing Medical University
2024
Nantong University
2017-2024
Michigan United
2007-2023
Hainan Medical University
2020-2023
Histotripsy is a therapy that focuses short-duration, high-amplitude pulses of ultrasound to incite localized cavitation cloud mechanically breaks down tissue. To investigate the mechanism formation, high-speed photography was used observe clouds generated during single histotripsy pulses. Pulses 5−20 cycles duration were applied transparent tissue phantom by 1-MHz spherically focused transducer. Clouds initiated from bubbles formed initial pulse, and grew along acoustic axis opposite...
We demonstrate a new optical approach to generate high-frequency (>15 MHz) and high-amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A nano-composite film of carbon nanotubes (CNTs) elastomeric polymer is formed on concave lenses as an efficient optoacoustic source due the high absorption CNTs rapid heat transfer upon excitation by pulsed laser irradiation. The CNT-coated unprecedented pressures >50 MPa in peak positive tight focal spot 75 μm lateral 400...
Background Developing the ability to use tumor-directed therapies trigger potentially therapeutic immune responses against cancer antigens remains a high priority for immunotherapy. We hypothesized that histotripsy, novel non-invasive, non-thermal ablation modality uses ultrasound-generated acoustic cavitation disrupt tissues, could engender adaptive tumor antigens. Methods Immunocompetent C57BL/6 mice inoculated with flank melanoma or hepatocellular carcinoma tumors were treated thermal...
Rationale Current hepatic locoregional therapies are limited in terms of effectiveness and toxicities. Given promising pre-clinical results, a first in-human trial was designed to assess the technical safety profile histotripsy, noninvasive, non-thermal, non-ionizing focused ultrasound therapy that creates precise, predictable tissue destruction, patients with primary secondary liver tumors.Methods A multicenter phase I (Theresa Study) performed single country 8 weeks planned follow-up....
The ability of ultrasound to produce highly controlled tissue erosion was investigated. This study is motivated by the need develop a noninvasive procedure perforate neonatal atrial septum as first step in treatment hypoplastic left heart syndrome. A total 232 holes were generated 40 pieces excised porcine wall 788 kHz single-element transducer. effects various parameters [e.g., pulse repetition frequency (PRF), duration (PD), and gas content liquid] on rate energy efficiency explored. An...
Previous studies showed that ultrasound can mechanically remove tissue in a localized, controlled manner. Moreover, enhanced acoustic backscatter is highly correlated with the erosion process. "Initiation" and "extinction" of this backscattering environment were studied paper. The relationship between initiation erosion, variability extinction, effects pulse intensity gas saturation on time to (initiation delay time) investigated. A 788-kHz single-element transducer was used. Multiple pulses...
Histotripsy is a non-invasive tissue ablation method capable of fractionating by controlling acoustic cavitation. To determine the fractionation susceptibility various tissues, we investigated histotripsy-induced damage on phantoms and ex vivo tissues with different mechanical strengths. A histotripsy bubble cloud was formed at phantom surfaces using 5-cycle long ultrasound pulses peak negative pressure 18 MPa PRFs 10, 100, 1000 Hz. Results showed significantly smaller lesions were generated...
Histotripsy produces tissue fractionation through dense energetic bubble clouds generated by short, high-pressure, ultrasound pulses. Conventional histotripsy treatments have used longer pulses from 3 to 10 cycles, wherein the lesion-producing cloud generation depends on pressure-release scattering of very high peak positive shock fronts previously initiated, sparsely distributed bubbles (the shock-scattering mechanism). In our recent work, negative pressure (P-) for directly a single half...
Histotripsy is an ultrasound ablation method that depends on the initiation and maintenance of a cavitation bubble cloud to fractionate soft tissue. This paper studies how tissue properties impact pressure threshold initiate cloud. Our previous study showed shock scattering off one or more initial bubbles, expanded sufficient size in focus, plays important role initiating dense In this process, causes positive phase be inverted, resulting scattered wave has opposite polarity incident shock....
Histotripsy is an ultrasound ablation method that controls cavitation to fractionate soft tissue. In order effectively tissue, histotripsy requires bubbles rapidly expand from nanometer-sized initial nuclei into often larger than 50 µm. Using a negative pressure high enough initiate bubble cloud and sufficient size, has been shown capable of completely fractionating tissue acelluar debris resulting in effective removal. Previous work the process affected by mechanical properties with stiffer...
Introduction Histotripsy is a novel focused ultrasound tumor ablation modality with potent immunostimulatory effects. Methods To measure the spatiotemporal kinetics of local andabscopal responses to histotripsy, C57BL/6 mice bearing bilateral flank B16 melanoma or Hepa1-6 hepatocellular carcinoma tumors were treated unilateral sham partial histotripsy. Treated and contralateral untreated (abscopal) analyzed using multicolor immunofluorescence, digital spatial profiling, RNA sequencing...
Background Histotripsy is a nonthermal, nonionizing, noninvasive, focused US technique that relies on cavitation for mechanical tissue breakdown at the focal point. Preclinical data have shown its safety and technical success in ablation of liver tumors. Purpose To evaluate histotripsy destroying primary or metastatic Materials Methods The parallel United States European Union England #HOPE4LIVER trials were prospective, multicenter, single-arm studies. Eligible patients recruited 14 sites...
Background— The primary objective of this study was to develop an image-guided, noninvasive procedure create or enlarge atrial septal defect for the treatment neonates with hypoplastic left heart syndrome and intact restrictive septum. Histotripsy is innovative ultrasonic technique that produces nonthermal, mechanical tissue fractionation through use high-intensity ultrasound pulses. This article reports pilot in vivo extracardiac application histotripsy open-chest canine model. Methods...
High intensity pulsed ultrasound can produce significant mechanical tissue fractionation with sharp boundaries ("histotripsy"). At a tissue-fluid interface, histotripsy produces clearly demarcated erosion and the efficiency depends on pulse parameters. Acoustic cavitation is believed to be primary mechanism for process. To investigate physical basis of dependence parameters, an optical method was used monitor effects parameters cavitating bubble cloud generated by pulses at tissue-water...