A5038837133- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Microbial Inactivation Methods
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Toxin Mechanisms and Immunotoxins
- Microfluidic and Bio-sensing Technologies
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Venous Thromboembolism Diagnosis and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Dose and Imaging
- Lanthanide and Transition Metal Complexes
- Electron Spin Resonance Studies
- Vascular Procedures and Complications
- Cancer Mechanisms and Therapy
- Magnetic and Electromagnetic Effects
- Radiation Effects and Dosimetry
- Plasma Applications and Diagnostics
- Gallbladder and Bile Duct Disorders
- Hepatitis B Virus Studies
- Aortic aneurysm repair treatments
Klinikum Braunschweig
2018-2025
University Hospital Regensburg
2011-2024
University Hospital Magdeburg
2024
University of Kansas Medical Center
2024
Baptist Hospital of Miami
2024
University of Regensburg
2011-2018
University Medical Center
2012-2013
Research Institute of Radiology
2013
American Association of Neurological Surgeons
2013
American College of Radiology
2013
Background Histotripsy is a nonthermal, nonionizing, noninvasive, focused US technique that relies on cavitation for mechanical tissue breakdown at the focal point. Preclinical data have shown its safety and technical success in ablation of liver tumors. Purpose To evaluate histotripsy destroying primary or metastatic Materials Methods The parallel United States European Union England #HOPE4LIVER trials were prospective, multicenter, single-arm studies. Eligible patients recruited 14 sites...
Objective: To evaluate the 1-year clinical outcomes of patients enrolled in #HOPE4LIVER trial hepatic histotripsy. Summary Background Data: Histotripsy is a novel non-invasive, non-thermal focused ultrasound therapy that liquefies tissue at focal point transducer. Following diagnostic targeting, an automated treatment performed via robotic arm to treat user-defined volume tissue. Methods: Forty-seven were 14 sites United States and Europe. Included ineligible for or had opted out standard...
To assess the differences between normal and cirrhotic livers by means of T1 mapping liver parenchyma on gadoxetic acid (Gd-EOB-DTPA)-enhanced 3 Tesla (3T) MR imaging (MRI).162 patients with (n = 96) 66; Child-Pugh class A, n 30; B, 28; C, 8) underwent Gd-EOB-DTPA-enhanced 3T MRI. obtain maps, two TurboFLASH sequences (TI 400 ms 1000 ms) before 20 min after Gd-EOB-DTPA administration were acquired. relaxation times reduction rate pre- post-contrast enhancement images measured.The for MRI...
Background:This study is an outcome evaluation of the Drug-Eluting-Bead-Chemoembolization (DEB TACE) compared to conventional TACE (cTACE) with Cisplation and Lipiodol in patients hepatocellular carcinoma (HCC) Child-Pugh A Cirrhosis.
Abstract Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and properties increasing evidence has emerged suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagnostic performance relaxometry-based commonly signal-intensity (SI)-based indices, including hepatocellular...
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on integrity hepatocyte mass, this can be quantified to assess liver function. We report relationship between extent and degree fibrosis. T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before 20 minutes after injection. Strong correlations characteristics relative...
Abstract Aim of this retrospective analysis was to evaluate the survival times after percutaneous irreversible electroporation (IRE) in inoperable liver tumors not amenable thermal ablation. 71 patients (14 females, 57 males, median age 63.5 ± 10.8 years) with 103 were treated 83 interventions using IRE (NanoKnife ® system). The tumor short-axis diameter 1.9 cm (minimum 0.4 cm, maximum 4.5 cm). 35 had primary and 36 metastases. Kaplan-Meier method employed calculate rates, different groups...
Background and Aims: Intermediate stage hepatocellular carcinoma (HCC) can be treated by transarterial chemoembolization (TACE). However, there appear to side effects, such as induction of proangiogenic factors, e.g. vascular endothelial growth factor (VEGF), which have been shown associated with a poor prognosis. This prospective study was designed compare serum VEGF level response after TACE different embolic agents in patients HCC. Methods: Patients were assigned one three regimens:...
Background Mass-forming focal pancreatitis (FP) may mimic pancreatic cancer (PC) on magnetic resonance (MR) imaging, and the preoperative differential diagnosis is often difficult. Recently, usefulness of diffusion-weighted imaging (DWI) in has been reported several studies. Purpose To investigate if apparent diffusion coefficient (ADC) measurements based echo-planar (DW-EPI) distinguish between normal pancreas parenchyma, mass-forming pancreatitis, carcinoma. Material Methods MRI was...
Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its uptake and paramagnetic properties, functioning areas of the liver exhibit shortening T1 relaxation time. We report potential use relaxometry with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating function as expressed by MELD score. 3 T was performed before 20 min after administration. A strong correlation between changes in extent disease, score, documented. Reduced correlates decreased accumulation...
5-Fluorouracil (5FU), Folinic acid (FA), and Oxaliplatin (FOLFOX) or 5FU, FA, Irinotecan (FOLFIRI) are standard regimens for palliative chemotherapy of metastatic colon cancer. Since data showing the influence dose reduction in treatment rare, objective this single center, retrospective study was to further characterize on efficacy these therapeutic regimens.One hundred nine patients, diagnosed with stage IV cancer between 2004 2012 receiving first-line either FOLFOX FOLFIRI our outpatient...
Abstract Purpose Image-guided thermal ablation are established treatment options for non-surgical patients with primary and metastatic liver cancers. However, there limitations nonuniformity of cancer tissue destruction, heat sink effect the risk ablative injury. The current non-thermal techniques have high local recurrence not widely adopted. Histotripsy is a technology that destroys targeted under ultrasound visualization via mechanical destruction through precise application acoustic...
Oxygenator thrombosis is a serious complication in extracorporeal membrane oxygenation (ECMO) and may necessitate system exchange. Coagulation fibrinolysis parameters, flow dynamics, gas transfer performance are currently used to evaluate the degree of oxygenator thrombosis, but there no technical approach for direct visualization quantification thrombotic deposits within (MO). We multidetector computed tomography (MDCT) with three-dimensional postprocessing assess incidence quantify...
The purpose of this study was to compare contrast-enhanced ultrasound (CEUS), magnetic resonance imaging (MRI) using liver-specific contrast agent and a combination both for the characterization focal liver lesions (FLL). 83 patients with benign malignant were examined CEUS MRI after intravenous administration media. All had inconclusive results from prior examinations. Histopathological specimens could be obtained in 53 patients. Ultrasound performed multi-frequency curved probe (1 - 6 MHz)...
We aimed to describe the frequency of adverse events after computed tomography (CT) fluoroscopy-guided irreversible electroporation (IRE) malignant hepatic tumors and their risk factors.We retrospectively analyzed 85 IRE ablation procedures 114 liver (52 primary 62 secondary) not suitable for resection or thermal in 56 patients (42 men 14 women; median age, 61 years) with regard mortality treatment-related complications. Complications were evaluated according standardized grading system...