A5054173938- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Diagnosis and Treatment of Venous Diseases
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Atrial Fibrillation Management and Outcomes
- Platelet Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Central Venous Catheters and Hemodialysis
- Ultrasound Imaging and Elastography
- Angiogenesis and VEGF in Cancer
- Galectins and Cancer Biology
- Surgical site infection prevention
- Veterinary Pharmacology and Anesthesia
- Photoacoustic and Ultrasonic Imaging
- Adipokines, Inflammation, and Metabolic Diseases
- Spine and Intervertebral Disc Pathology
- Lipoproteins and Cardiovascular Health
- Aortic aneurysm repair treatments
- Surgical Sutures and Adhesives
- Acute Myocardial Infarction Research
University of Michigan–Ann Arbor
2016-2025
Michigan Medicine
2002-2025
Allegheny Health Network
2024
Allegheny General Hospital
2020-2024
Royal Adelaide Hospital
2020
Bristol-Myers Squibb (United States)
2017
Smith & Nephew (United Kingdom)
2017
University of Manchester
2016
Manchester University NHS Foundation Trust
2016
Archemix (United States)
2015
Neutrophil extracellular traps (NETs) are part of the innate immune response to infections. NETs a meshwork DNA fibers comprising histones and antimicrobial proteins. Microbes immobilized in encounter locally high lethal concentration effector Recent studies show that formed inside vasculature infections noninfectious diseases. Here we report provide heretofore unrecognized scaffold stimulus for thrombus formation. perfused with blood caused platelet adhesion, activation, aggregation. DNase...
Background: Interventional therapies to relieve chronic deep vein thrombosis (DVT) fail through inability penetrate, cross, and remove the occlusion. Development of suitable tools requires fundamental understanding DVT mechanical properties a reliable model for testing. Methods: Female farm swine underwent novel, endovenous generation long-segment unilateral iliac thrombosis. Thrombus was confirmed via venogram, intravascular ultrasound, transabdominal duplex 14 days. components were...
Summary Current plasma markers for diagnosis of deep venous thrombosis (DVT) allow exclusion the diagnosis, but lack adequate specificity to establish diagnosis. Thus, a prospective study was performed determine sensitivity and assays D-dimer, soluble P-selectin (P-selectin), total microparticles in patients with documented DVT by duplex ultrasound. Three groups individuals were examined: 30 normals; 22 positive on ultrasound (Group 2); 21 symptomatic, negative 3). Group 1 had D-dimer values...
Objective: The combination of D-dimer and Wells score can exclude, but not confirm, the diagnosis deep venous thrombosis (DVT). Since inflammation are interrelated, we evaluated soluble P-selectin (sPsel) with other inflammatory biomarkers for DVT. Methods: Sixty-two positive one hundred sixteen patients negative DVT, by duplex scan, were prospectively sPsel, D-dimer, C-reactive protein (CRP), microparticles (MPs; total, leukocyte, platelet-derived tissue factor microparticles), clinical...
Aptamers are oligonucleotides targeting protein-protein interactions with pharmacokinetic profiles and activity reversal options. Although P-selectin von Willebrand factor (vWF) have been implicated in the development of venous thrombosis (VT), no studies directly compared aptamer efficacy standard care VT. In this study, ARC5692, an anti-P-selectin aptamer, ARC15105, anti-vWF were low-molecular-weight heparin, enoxaparin, to test or vWF inhibition promoting thrombus resolution preventing...
Due to exciting advances in molecular biology, the laboratory mouse has become an important and frequently used model for studying thrombosis. This article reviews several experimental approaches that have been study arterial, venous, microvascular thrombosis mice. The advantages limitations of different models are examined. Related topics anesthesia, phlebotomy, vitro hemostasis testing also reviewed.
Summary Microparticles (MP) are lipid vesicles from platelets, leukocytes and endothelial cells that involved in early thrombogenesis. We evaluated a detailed time-course analysis of MPs on thrombogenesis the associated tissue factor (TF) activity wild-type, gene-deleted for E- P-selectins with high levels P-selectin expression after initiation venous thrombosis mice.Inferior vena cava (IVC) ligation was performed C57BL/6 mice (n =191, 59 = wild-type [WT], 55 P – selectins [knock-outs, EPKO]...
Acoustic droplet vaporization (ADV) is an emerging technique with expanding applications in biomedical ultrasound. ADV-generated bubbles can function as microscale probes that provide insights into the mechanical properties of their surrounding microenvironment. This study investigated acoustic and imaging characteristics phase-shift nanodroplets fibrin-based, tissue-mimicking hydrogels using passive cavitation detection active techniques, including B-mode contrast-enhanced The findings...