A5111742905- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Gut microbiota and health
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Eicosanoids and Hypertension Pharmacology
- Diabetes Treatment and Management
- Wnt/β-catenin signaling in development and cancer
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Hormonal Regulation and Hypertension
- Viral Infections and Vectors
- Pharmacology and Obesity Treatment
- Nitric Oxide and Endothelin Effects
- Liver physiology and pathology
Second Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Nanchang University
2014-2025
Shenzhen University
2025
Peking University First Hospital
2023-2024
Peking University
2023-2024
China General Nuclear Power Corporation (China)
2024
Jiangsu University
2022-2024
Chongqing Medical University
2023-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Dalian Medical University
1990-2024
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) not defined. Here, we found that subdiaphragmatic vagotomy in LSL-Kras +/G12D;Pdx1-Cre (KC) mice accelerated PDAC development, whereas treatment with systemic muscarinic agonist bethanechol restored normal KC phenotype, thereby suppressing tumorigenesis caused...
In this study, we investigated the role of SERPINH1 in gastric cancer (GC) progression. GC patient tissues show significantly higher mRNA and protein levels than normal mucosal tissues. patients with high expression are associated lymph node metastasis poor prognosis. negatively correlate E-cadherin positively N-cadherin, MMP2, MMP9 levels. This suggests regulates epithelial to mesenchymal transition (EMT). was HGC-27, AGS, MGC-803, SGC-7901 cell lines GES-1 line. SERPINH1-silenced cells,...
Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), CHARGE syndrome, is indispensable for normal cerebellar development. Genetic inactivation of Chd7 granule neuron progenitors leads to hypoplasia mice, due impairment differentiation, induction apoptosis and abnormal localization Purkinje cells, which closely recapitulates known clinical features cerebella...
Epidemiological evidence suggests a role for sex-dependent mechanisms in the pathophysiology of hypertension. It has been shown that 5alpha-dihydrotestosterone (DHT) administration (56 mg/kg body weight per day IP 14 days) increases blood pressure, cytochrome P450 4A expression, and 20-hydroxyeicosatetraenoic acid synthesis rats. We examined whether increased vascular underlies endothelial dysfunction hypertension DHT-treated male Sprague-Dawley rats by using HET0016, selective inhibitor....
IBI362 (LY3305677) is a novel weekly-dose glucagon-like peptide-1 and glucagon receptor dual agonist being developed for the treatment of obesity type 2 diabetes. The aim this randomised, placebo-controlled, multiple ascending dose phase 1b study was to evaluate safety, tolerability, pharmacokinetics efficacy in Chinese adults with overweight or obesity.This enrolled (body mass index [BMI]≥24 kg/m2) accompanied by hyperphagia and/or at least one comorbidity (BMI≥28 from six centres China....
Abstract The success of glucagon-like peptide-1 (GLP-1) receptor agonists to treat type 2 diabetes (T2D) and obesity has sparked considerable efforts develop next-generation co-agonists that are more effective. We conducted a randomised, placebo-controlled phase 1b study (ClinicalTrials.gov: NCT04466904) evaluate the safety efficacy IBI362 (LY3305677), GLP-1 glucagon dual agonist, in Chinese patients with T2D. A total 43 T2D were enrolled three cohorts nine centres China randomised each...
Abstract Background Heterozygous familial hypercholesterolemia (HeFH) is largely underdiagnosed and undertreated in China where few patients achieved recommended target levels of low density lipoprotein cholesterol (LDL-C). We conducted the first randomized, placebo-controlled clinical trial Chinese with HeFH to assess efficacy safety tafolecimab, a novel fully human proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody. Methods Patients diagnosed by Simon Broome criteria...
Solid-pseudopapillary neoplasm of the pancreas is a rare tumor uncertain histogenesis that characterized by cystic and solid growth pattern with pseudopapillary structures. The differentiation solid-pseudopapillary from other pancreatic tumors great importance. However, it sometimes difficult because similarities in morphologic features immunophenotype. CD99 diagnostically useful marker for Ewing sarcoma/primitive neuroectodermal tumor. aim this study was to investigate diagnostic value...
Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddase, yielding soluble (sTim-3). This study investigated serum sTim-3 levels patients with infection of various liver diseases.Serum were quantitatively determined 288 diseases. analyzed relation diseases including HBV-related hepatocellular...
The chemokine receptor CCR5, which belongs to the superfamily of G protein-coupled receptors, is major co-receptor for HIV-1 entry. Individuals with a homozygous CCR5Δ32 mutation have long lasting and increased resistance infection. Therefore, CCR5 represents an optimal target HIV-1/AIDS gene therapy. CRISPR/Cas9 system has been developed as one most efficacious editing tools in mammalian cells small-sized version from Staphylococcus aureus (SaCas9) advantage easier delivery compared...
As one of the most common malignant gastrointestinal tumors, gastric cancer (GC) has a high incidence and poor prognosis. Cisplatin (DDP) is often used as chemotherapy for advanced GC; however, drug resistance remains problem. The use several anti-tumor drugs combined an effective strategy. Hesperetin ability via its pro-apoptotic effect on various human cancers, both in vitro vivo, with no significant toxicity. However, combination DDP hesperetin GC not been reported. present study aimed to...
Adipocyte is the most predominant cell type in tumor microenvironment of breast cancer and plays a pivotal role progression, yet underlying mechanisms functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads human patients generated mature adipocytes cancer-associated (CAAs) vitro. The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing. One highly expressed genes granulocyte colony-stimulating factor...
Background Circular RNAs (circRNAs) regulate multiple malignant behaviors of various types cancer. The role circDNMT1, a newly identified circRNA, remains unknown in gastric cancer (GC). This study aimed to elucidate the underlying mechanisms circDNMT1 regulating GC progression. Methods microRNA (miRNA) and circRNA expression was detected by quantitative real-time PCR. Western blotting performed measure hypoxia inducible factor-1 alpha (HIF-1α) protein expression. Sanger sequencing, gel...
Tafolecimab is a novel fully human proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody, developed for the treatment of hypercholesterolemia. To assess efficacy and safety tafolecimab in Chinese patients at high or very cardiovascular risk with Patients diagnoses heterozygous familial hypercholesterolemia (HeFH) by Simon Broome criteria nonfamilial hypercholesterolemia, screening low-density lipoprotein cholesterol (LDL-C) level ≥1.8 mmol/L, were randomized 2:1 to...
Intestinal barrier dysfunction is widely observed in patients with irritable bowel syndrome (IBS) and significantly contributes to the persistence of IBS symptoms. The association between gut dysbiosis pathogenesis IBS, as well its connection intestinal dysfunction, has been established. However, precise roles bacteria inducing underlying mechanisms remain unclear. In present study, we showed that microbiota-derived lithocholic acid (LCA) positively associated biomarkers IBS-D. We found...
Background This study aims to evaluate the association between hypertension and risk of fibrosis in metabolic dysfunction–associated steatotic liver disease (MASLD) patients, as well investigate impact on progression within this population. Methods We utilized data from NHANES 2017 March 2020. Multivariate logistic regression models were employed control for sociodemographic factors determine associations hypertension, MASLD, fibrosis. Results Of total cohort ( N = 5,967) 57.92% had 38.8%...