A5021727271- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Human Pose and Action Recognition
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced Vision and Imaging
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Multimodal Machine Learning Applications
- Bone health and treatments
- Circular RNAs in diseases
- Cryptography and Data Security
- Lipid metabolism and disorders
- Organ Transplantation Techniques and Outcomes
- Bone Metabolism and Diseases
- Oral and Maxillofacial Pathology
- Parathyroid Disorders and Treatments
- Plant Pathogens and Fungal Diseases
- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Sirtuins and Resveratrol in Medicine
- TGF-β signaling in diseases
- Generative Adversarial Networks and Image Synthesis
Stomatology Hospital
2015-2025
Zhejiang University
2007-2025
Southern Medical University
2018-2025
Zhujiang Hospital
2018-2025
Peking University
2001-2025
Peking University People's Hospital
2024-2025
Queen's University Belfast
2024
Second Affiliated Hospital of Fujian Medical University
2006-2024
Fujian Medical University
2006-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Data for face analysis often exhibit highly-skewed class distribution, i.e., most data belong to a few majority classes, while the minority classes only contain scarce amount of instances. To mitigate this issue, contemporary deep learning methods typically follow classic strategies such as re-sampling or cost-sensitive training. In paper, we conduct extensive and systematic experiments validate effectiveness these schemes representation on class-imbalanced data. We further demonstrate that...
Vascular calcification is highly prevalent in patients with chronic kidney disease. Increased plasma trimethylamine N-oxide (TMAO), a gut microbiota-dependent product, concentrations are found undergoing hemodialysis. However, clear mechanistic link between TMAO and vascular not yet established. In this study, we investigate whether participates the progression of using vitro, ex vivo, vivo models. Approach Results: Alizarin red staining revealed that promoted calcium/phosphate-induced rat...
We present a novel approach for the task of human pose transfer, which aims at synthesizing new image person from an input that and target pose. address issues limited correspondences identified between keypoints only invisible pixels due to self-occlusion. Unlike existing methods, we propose estimate dense intrinsic 3D appearance flow better guide transfer poses. In particular, wish generate just reference Training network this purpose is non-trivial, especially when annotations are scarce...
Recent studies on 2D pose estimation have achieved excellent performance public benchmarks, yet its application in the industrial community still suffers from heavy model parameters and high latency. In order to bridge this gap, we empirically explore key factors including paradigm, architecture, training strategy, deployment, present a high-performance real-time multi-person framework, RTMPose, based MMPose. Our RTMPose-m achieves 75.8% AP COCO with 90+ FPS an Intel i7-11700 CPU 430+ NVIDIA...
Abstract Vascular calcification is a common pathologic condition in patients with chronic kidney disease (CKD) and aging individuals. It has been established that vascular gene‐regulated biological process resembling osteogenesis involving osteogenic differentiation. However, there no efficient treatment available for so far. The natural polyamine spermidine demonstrated to increase life span protect against cardiovascular disease. unclear whether supplementation inhibits CKD. Alizarin red...
Non-muscle invasive bladder cancer (NMIBC) is a major type of with high incidence worldwide, resulting in great disease burden. Treatment and surveillance are the most important part NIMBC management. In 2018, we issued "Treatment for non-muscle-invasive China: an evidence-based clinical practice guideline". Since then, various studies on treatment NMIBC have been published. There need to incorporate these materials also take into account relatively limited medical resources primary...
Vascular calcification (VC) is prevalent in pathological processes such as diabetes, chronic kidney disease (CKD), and atherosclerosis, but effective therapies are still lacking by far. Canagliflozin (CANA), a sodium-glucose cotransporter 2 inhibitor, has been approved for the treatment of type diabetes mellitus exhibits beneficial effects against cardiovascular disease. However, effect CANA on VC remains unknown. In this study, we hypothesize that protects VC.Micro-computed tomography...
The evolution of Large Language Models (LLMs) like ChatGPT and GPT-4 has sparked discussions on the advent Artificial General Intelligence (AGI). However, replicating such advancements in open-source models been challenging. This paper introduces InternLM2, an LLM that outperforms its predecessors comprehensive evaluations across 6 dimensions 30 benchmarks, long-context modeling, open-ended subjective through innovative pre-training optimization techniques. process InternLM2 is meticulously...
High-risk human papillomaviruses (HPVs) are causative agents of anogenital cancers and a fraction head neck cancers. The mechanisms involved in the progression HPV neoplasias to remain largely unknown. Here, we report that O-linked GlcNAcylation (O-GlcNAc) O-GlcNAc transferase (OGT) were markedly increased HPV-caused cervical neoplasms relative normal cervix, whereas O-GlcNAcase (OGA) levels not altered. Transduction HPV16 oncogene E6 or E6/E7 into mouse embryonic fibroblasts (MEFs)...
Multitask joint learning technology continues gaining more attention as a paradigm shift and has shown promising performance in many applications. Depth estimation semantic understanding from monocular images emerge challenging problem computer vision. While the other frameworks establish relationship between semantics depth stereo pairs, lack of camera motion renders that fail to model geometric structure image scene. We make further step this article by proposing multitask method, namely...
Abstract Vascular calcification is an actively regulated process resembling bone formation and contributes to the cardiovascular morbidity mortality of chronic kidney disease (CKD). However, effective therapy for vascular still lacking. The ketone body β‐hydroxybutyrate (BHB) has been demonstrated have health‐promoting effects including anti‐inflammation protective effects. whether BHB protects against in CKD remains unclear. In this study, Alizarin Red staining calcium content assay showed...
We introduce InternLM-XComposer2, a cutting-edge vision-language model excelling in free-form text-image composition and comprehension. This goes beyond conventional understanding, adeptly crafting interleaved content from diverse inputs like outlines, detailed textual specifications, reference images, enabling highly customizable creation. InternLM-XComposer2 proposes Partial LoRA (PLoRA) approach that applies additional parameters exclusively to image tokens preserve the integrity of...
Abstract Vascular calcification is an actively regulated biological process resembling bone formation, and osteogenic differentiation of vascular smooth muscle cells (VSMCs) plays a crucial role in this process. 1‐Palmitoyl‐2‐(5′‐oxo‐valeroyl)‐sn‐glycero‐3‐phosphocholine (POVPC), oxidized phospholipid, found atherosclerotic plaques has been shown to induce oxidative stress. However, the effects POVPC on VSMCs have yet be studied. In present study, we investigated using vitro ex vivo models....
Plasmid-mediated gene therapy can restore dystrophin expression in skeletal muscle the mdx mouse, a model of Duchenne muscular dystrophy. However, sufficient long-term and distribution remain hurdle for translating this technology into viable treatment To improve plasmid-mediated diseases, we studied effects targeted plasmid integration using phage integrase (φC31) that mediate suitably modified plasmids mammalian genome. Using luciferase plasmid, monitored noninvasively living mice by...
Adipocyte is the most predominant cell type in tumor microenvironment of breast cancer and plays a pivotal role progression, yet underlying mechanisms functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads human patients generated mature adipocytes cancer-associated (CAAs) vitro. The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing. One highly expressed genes granulocyte colony-stimulating factor...