A5069659184- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Orthopaedic implants and arthroplasty
- Catalytic Processes in Materials Science
- Flame retardant materials and properties
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Surgical Sutures and Adhesives
- Industrial Gas Emission Control
- Adipokines, Inflammation, and Metabolic Diseases
- Air Quality and Health Impacts
- Polymer crystallization and properties
- Dental Implant Techniques and Outcomes
- Aerosol Filtration and Electrostatic Precipitation
- 3D Printing in Biomedical Research
- Catalysis and Oxidation Reactions
- Polymer Surface Interaction Studies
- Cardiovascular Disease and Adiposity
- Nanocomposite Films for Food Packaging
- Vehicle emissions and performance
- Silk-based biomaterials and applications
- Synthesis and properties of polymers
Xihua University
2023-2024
Affiliated Hospital of North Sichuan Medical College
2023
North Sichuan Medical University
2023
Shanghai Ocean University
2022-2023
Purdue University West Lafayette
2015-2022
Shandong Province Meteorological Bureau
2019
North China University of Science and Technology
2018
Center for Cancer Research
2017
University of North Carolina at Chapel Hill
2015
UConn Health
2011-2014
One of the fundamental principles underlying tissue engineering approaches is that newly formed must maintain sufficient vascularization to support its growth. Efforts induce vascular growth into tissue-engineered scaffolds have recently been dedicated developing novel strategies deliver specific biological factors direct recruitment endothelial cell (EC) progenitors and their differentiation. The challenge, however, lies in orchestration cells, appropriate factors, optimal factor doses....
Abstract Successful bone regeneration benefits from three‐dimensional (3D) bioresorbable scaffolds that mimic the hierarchical architecture and mechanical characteristics of native tissue extracellular matrix (ECM). A scaffold platform integrates unique material chemistry with nanotopography while mimicking 3D mechanics is reported. biocompatible dipeptide polyphosphazene‐polyester blend electrospun to produce fibers in diameter range 50–500 nm emulate dimensions collagen fibrils present...
Tissue engineering often utilizes biodegradable polymers in the form of porous scaffolds for regenerating de novo tissues. There is an ever-increasing need as temporary substrates facilitating tissue regeneration. Compared to widely used polyesters, polyorthoesters, poly(α-amino acids), and poly(anhydrides), polyphosphazenes a unique class that has vast potential applications. Polyphosphazenes are linear high molecular weight with inorganic backbone consisting alternating phosphorous...
Scaffold based bone tissue engineering (BTE) has made great progress in regenerating lost tissue. Materials of natural and synthetic origin have been used for scaffold fabrication. Scaffolds derived from polymers offer greater bioactivity biocompatibility with mammalian tissues to favor healing, due their similarity native extracellular matrix (ECM) components. Often it is a challenge fabricate polymer scaffolds BTE applications without compromising bioactivity, while maintaining adequate...
The lipid droplet (LD) is a central hub for fatty acid metabolism in cells. Here we define the dynamics and explore role of LDs skeletal muscle satellite cells (SCs), stem cell population responsible regeneration. In newly divided SCs, are unequally distributed sister exhibiting asymmetric fates, as LDLow self-renews while LDHigh commits to differentiation. When transplanted into regenerating muscles, outperform self-renewal regeneration vivo. Pharmacological inhibition LD biogenesis or...
Regeneration of skeletal muscles is limited in cases volumetric muscle loss and degenerative diseases. Therefore, there a critical need for developing strategies that provide cellular structural support regeneration. In the present work, bioengineered cell niche composed mechanically competent aligned polyester fiber scaffolds developed to mimic oriented microenvironment by electrospinning poly(lactide-co-glycolide) (PLGA) using custom designed rotating collector with interspaced parallel...
Poly[(ethyl alanato)1(p-methyl phenoxy)1] phosphazene (PNEA-mPh) was used to modify the surface of electrospun poly(ε-caprolactone) (PCL) nanofiber matrices having an average fiber diameter 3000 ± 1700 nm for purpose tendon tissue engineering and augmentation. This study reports effect polyphosphazene functionalization on human mesenchymal stem cell (hMSC) adhesion, cell-construct infiltration, proliferation differentiation, as well long term cellular construct mechanical properties. PCL...
Inhibition of Notch signaling via systemic drug administration triggers conversion white adipocytes into beige (browning) and reduces adiposity. However, translation this discovery clinical practice is challenged by potential off-target side effects lack control over the location temporal extent adipocyte biogenesis. Here, we demonstrate an alternative approach to stimulate browning using nanoparticles (NPs) composed FDA-approved poly(lactide-co-glycolide) that enable sustained local release...
Volumetric muscle loss (VML) injuries characterized by critical of skeletal tissues result in severe functional impairment. Current treatments involving use grafts are limited tissue availability and donor site morbidity. In this study, we designed synthesized an implantable glycosaminoglycan-based hydrogel system consisting thiolated hyaluronic acid (HA) chondroitin sulfate (CS) cross-linked with poly(ethylene glycol) diacrylate to promote regeneration VML mice. The HA-CS hydrogels were...
Abstract Constructing antifouling coatings for biosensing interfaces is a major hurdle in driving their practical application. Inspired by the excellent properties of natural cell membranes, conductive biomimetic interface coating proposed, which highly mimics biofilms while overcoming low conductivity defects conventional coatings. Polyethylene glycol–Au gel selected as support structure and electron transfer layer, on phospholipids ampholytes are applied to construct hydration layer...
Abstract Synthetic biodegradable polymers serve as temporary substrates that accommodate cell infiltration and tissue in‐growth in regenerative medicine. To allow nutrient transport, traditional three‐dimensional (3D) scaffolds must be prefabricated with an interconnected porous structure. Here we demonstrated for the first time a unique polymer erosion process through which matrices evolve from solid coherent film to assemblage of microspheres 3D This system was developed on highly...
The success of the scaffold-based bone regeneration approach critically depends on biomaterial's mechanical and biological properties. Cellulose its derivatives are inherently associated with exceptional strength biocompatibility due to their β-glycosidic linkage extensive hydrogen bonding. This polymer class has a long medical history as dialysis membrane, wound care system pharmaceutical excipient. Recently cellulose-based scaffolds have been developed evaluated for variety tissue...
Abstract Synthetic biodegradable polymers serve as temporary substrates that accommodate cell infiltration and tissue in‐growth in regenerative medicine. To allow nutrient transport, traditional three‐dimensional (3D) scaffolds must be prefabricated with an interconnected porous structure. Here a unique polymer erosion process through which matrices evolve from solid coherent film to assemblage of microspheres 3D structure is demonstrated for the first time. This system developed on highly...