A5043567578- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Ocular Surface and Contact Lens
- Radioactive element chemistry and processing
- Corneal Surgery and Treatments
- Chemical Synthesis and Characterization
- 3D Printing in Biomedical Research
- Adipose Tissue and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Radiation Therapy and Dosimetry
- Cardiovascular Disease and Adiposity
- Saffron Plant Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle Physiology and Disorders
- Nanoplatforms for cancer theranostics
- Corneal surgery and disorders
- Proteoglycans and glycosaminoglycans research
- Supramolecular Self-Assembly in Materials
- Tissue Engineering and Regenerative Medicine
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Algal biology and biofuel production
- Cancer-related molecular mechanisms research
- Boron Compounds in Chemistry
- Osteoarthritis Treatment and Mechanisms
Massachusetts Eye and Ear Infirmary
2018-2024
Harvard University
2018-2024
Smith-Kettlewell Eye Research Institute
2018-2024
Purdue University West Lafayette
2015-2020
Colorado School of Mines
2011-2019
Boston Children's Hospital
2019
Beijing Normal University
2009
It is strategically important to recycle uranium from radioactive liquid wastes for future supply of nuclear energy. However, it still a challenge adsorb selectively highly acidic and waste. In this paper, we report novel strategy effective removal media by surface ion-imprinted mesoporous silica sorbent. The sorbent was successfully synthesized co-condensation method with uranyl as the template ion diethylphosphatoethyltriethoxysilane functional ligands. pseudo-second-order model Langmuir...
We report here a green chemistry method to conjugate hydrophobic payloads (Lilial as prototype) highly efficiently (35.8 wt %) with (1→4)-2-amino-2-deoxy-β-d-glucan (i.e., chitosan) via Schiff base bond formation in an ionic liquid, which renders chitosan easily dissolvable common organic solvents and amenable further functional modifications. As example, thermoresponsive poly(N-isopropylacrylamide) was grafted the chitosan−Lilial conjugate. The graft copolymer self-assembled water at...
Uranium seawater extraction is strategically important to the sustainable development of nuclear energy. Nevertheless, a challenge remains in uranium enrichment overcome microorganisms’ adhesion. In this article, we propose guanidine and amidoxime cofunctionalized polypropylene nonwoven fabric for potential with an antifouling property. Specifically, glycidyl methacrylate was first grafted onto under γ-ray irradiation, then reacted dicyandiamide, followed by amidoximation give functionalized...
Inhibition of Notch signaling via systemic drug administration triggers conversion white adipocytes into beige (browning) and reduces adiposity. However, translation this discovery clinical practice is challenged by potential off-target side effects lack control over the location temporal extent adipocyte biogenesis. Here, we demonstrate an alternative approach to stimulate browning using nanoparticles (NPs) composed FDA-approved poly(lactide-co-glycolide) that enable sustained local release...
Volumetric muscle loss (VML) injuries characterized by critical of skeletal tissues result in severe functional impairment. Current treatments involving use grafts are limited tissue availability and donor site morbidity. In this study, we designed synthesized an implantable glycosaminoglycan-based hydrogel system consisting thiolated hyaluronic acid (HA) chondroitin sulfate (CS) cross-linked with poly(ethylene glycol) diacrylate to promote regeneration VML mice. The HA-CS hydrogels were...
Cellular membranes are natural nanoengineering devices, where matter transport, information processing, and energy conversion across the nanoscale boundaries mediated by membrane proteins (MPs). Despite great potential of MPs for nanotechnologies, their broad utility in engineered systems is limited fluidic often labile nature MP-supporting membranes. Little known on how to direct spontaneous reconstitution into robust synthetic nanomembranes or tune MP functions through rational design...
The prevalent wisdom on developing membrane active antimicrobials (MAAs) is to seek a delicate, yet unquantified, cationic–hydrophobic balance. Inspired by phages that use nanostructured protein devices invade bacteria efficiently and selectively, we study here the antibiotic role of nanostructures designing spherical rod-like polymer molecular brushes (PMBs) mimic two basic structural motifs bacteriophages. Three model PMBs with different well-defined geometries consisting multiple,...
Manipulating recognition and transport at the nanoscale holds great promise for technological breakthroughs in energy conversion, catalysis, information processing. Living systems evolve specialized membrane proteins (MPs) embedded lipid bilayers to exquisitely control communications across insulating boundaries. Harnessing MP functions directly synthetic opens up enormous opportunities nanotechnology, but there exist fundamental challenges of how address labile nature that renders them...
Abstract High‐dose ionizing radiation can lead to death from the unrecoverable damage of gastrointestinal tract, especially small intestine. Until now, lack predilection for intestine and rapid clearance by digestive fluids limit effects conventional radioprotective formulations. Herein, an innovative strategy is developed attenuating syndrome smart oral administration nanodrugs. The nanodrug first engineered encapsulating thalidomide into chitosan‐based nanoparticles, then coated with...
Because of the rapid development and extensive use nuclear technology, ionizing radiation has become a large threat to human health. Until now, there been no practicable radioprotector for routine clinical application because severe side effects, high toxicity, short elimination half-life. Herein, we develop highly efficient radioprotection strategy using selenium-containing polymeric drug with low toxicity long circulation by removing reactive oxygen species (ROSs). The is prepared...
The current oral administration of drugs for cesium (Cs) decorporation treatment are often subject to side effects and low efficiency. Therefore, it is great significance, yet challenging, develop novel materials techniques efficient removal Cs from the human body. We report herein a new method directly removing blood by poly(ethylene glycol)-decorated Prussian blue magnetic nanoparticles (PEG-PB MNs). have been successfully synthesized one-pot hydrothermal reaction. adsorption in aqueous...
Brown and beige adipocytes are potent therapeutic agents to increase energy expenditure reduce risks of obesity its affiliated metabolic symptoms. One strategy adipocyte content is through inhibition the evolutionarily conserved Notch signaling pathway. However, systemic delivery inhibitors associated with off-target effects multiple dosages application further faces technical translational challenges. Here, we report development a biodegradable polymeric microsphere-based drug system for...
Abstract The tear fluid is a readily accessible, potential source for biomarkers of disease and could be used to monitor the ocular response contact lens (CL) wear or ophthalmic pathologies treated by therapeutic CLs. However, remains largely unexplored as biomarker RNA-based molecular analyses. Using rabbit model, this study sought determine whether RNA collected from commercial CLs duration CL would impact recovery. results were referenced standardized strips filtered paper (e.g., Shirmer...
Recombinant human nerve growth factor (rhNGF; cenegermin-bkbj, OXERVATE) is the first and only U.S. Food Drug Administration-approved treatment for moderate to severe neurotrophic keratopathy. The aim of this study was determine feasibility incorporating a version rhNGF in mucoadhesive hydrogel capable sustained drug release ocular surface.
Abstract G‐protein‐coupled receptors (GPCRs) are the largest family of membrane‐bound and constitute about 50 % all known drug targets. They offer great potential for membrane protein nanotechnologies. We report here a charge‐interaction‐directed reconstitution mechanism that induces spontaneous insertion bovine rhodopsin, eukaryotic GPCR, into both lipid‐ polymer‐based artificial membranes. reveal new allosteric mode rhodopsin activation incurred by non‐biological membranes: cationic drives...