A5009941698- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Extracellular vesicles in disease
- Hydrogels: synthesis, properties, applications
- Immunotherapy and Immune Responses
- Ocular Oncology and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Pain Management and Opioid Use
- Nanoplatforms for cancer theranostics
- Exercise and Physiological Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dental Anxiety and Anesthesia Techniques
- Opioid Use Disorder Treatment
- Ergonomics and Musculoskeletal Disorders
- Ophthalmology and Visual Impairment Studies
- Urinary Tract Infections Management
- Legionella and Acanthamoeba research
- Inflammasome and immune disorders
Massachusetts Eye and Ear Infirmary
2022-2025
Harvard University
2022-2025
Smith-Kettlewell Eye Research Institute
2022-2025
New England College of Optometry
2025
Aston University
2015-2021
Abstract Objective To determine whether sociodemographic factors affect the outcomes of patients with unstable keratoconus. Design Retrospective case control study Subjects All diagnosed keratoconus at Mass Eye and Ear between January 2016 October 2022. Those who experienced acute corneal hydrops during period were considered cases, those did not controls. Methods Potential subjects identified by billing code verified review clinical documentation. Charts reviewed for pertinent...
Background/aim To evaluate the opioid prescription patterns across ophthalmic subspecialties at a large academic eye centre. Methods A single site, retrospective cross-sectional study. Electronic medical records from year 2018 were screened. Ophthalmology patients ≥18 years of age included. The main outcome measures patient demographics, outpatient prescriptions, procedure and prescriber details, including department training level. Results 1654 prescriptions written, accounting for 2.2% all...
SIGNIFICANCE This randomized, masked, crossover clinical study identifies that ≥125 Dk materials should be used for scleral lens daily wear if disruption to corneal oxygen is minimized. PURPOSE Modern use has increased and proven successful where other types have previously failed. Although the required permeability been modeled, this not established clinically. METHODS Fifteen masked participants aged 20.7 ± 2.3 years (10 female) were bilaterally fitted with five different lenses (65, 100,...
Abstract The tear fluid is a readily accessible, potential source for biomarkers of disease and could be used to monitor the ocular response contact lens (CL) wear or ophthalmic pathologies treated by therapeutic CLs. However, remains largely unexplored as biomarker RNA-based molecular analyses. Using rabbit model, this study sought determine whether RNA collected from commercial CLs duration CL would impact recovery. results were referenced standardized strips filtered paper (e.g., Shirmer...
To collect tear fluid biomarkers from contact lenses (CLs) and determine the impact of CL wear duration.
This study aimed to develop a miltefosine-eluting contact lens (MLF-CL) device that would allow sustained and localized miltefosine release for the treatment of Acanthamoeba keratitis. MLF-CLs were produced in three different doses by solvent-casting thin miltefosine-polymer film around periphery methafilcon hydrogel, which was then lathed into lens. During seven days vitro testing, all formulations demonstrated from at theoretically therapeutic levels. Based on physicochemical...
Purpose: The aim of the study is to investigate US-based ophthalmologists’ preferred corneal transplant techniques and postoperative steroid regimen. Methods: Ophthalmologists attending 2021 Cornea Eye Banking Forum and/or Subspecialty Day were surveyed in person. Results: Ninety-two ophthalmologists with a median 13 years (range 1–35; mean 14.5; ±9.05 ± SD) experience as clinicians surveyed. One hundred percent surgeons performed penetrating keratoplasty, which was followed by 96.7% for...
Recombinant human nerve growth factor (rhNGF; cenegermin-bkbj, OXERVATE) is the first and only U.S. Food Drug Administration-approved treatment for moderate to severe neurotrophic keratopathy. The aim of this study was determine feasibility incorporating a version rhNGF in mucoadhesive hydrogel capable sustained drug release ocular surface.
Communication between the different layers of cornea (epithelium and stroma) is a complex, yet crucial element in corneal healing process. Upon injury, it has been reported that bi-directional cross talk epithelium stroma via vesicular secretome, namely, extracellular vesicles (EVs), can lead to accelerated wound closure upon injury. However, distinct protein markers EVs derived from human epithelial (HCE) cells, keratocytes (HCKs), fibroblasts (HCFs), myofibroblasts (HCMs) remain poorly...