Jason J. Nichols

ORCID: 0000-0003-1519-7734
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About
Contact & Profiles
Research Areas
  • Ocular Surface and Contact Lens
  • Corneal surgery and disorders
  • Glaucoma and retinal disorders
  • Ophthalmology and Visual Impairment Studies
  • Corneal Surgery and Treatments
  • Allergic Rhinitis and Sensitization
  • Contact Dermatitis and Allergies
  • Ocular Infections and Treatments
  • Retinal Diseases and Treatments
  • Advancements in Transdermal Drug Delivery
  • Facial Rejuvenation and Surgery Techniques
  • Skin Protection and Aging
  • Retinal and Optic Conditions
  • Salivary Gland Disorders and Functions
  • Intraocular Surgery and Lenses
  • Advanced Glycation End Products research
  • Olfactory and Sensory Function Studies
  • Connexins and lens biology
  • Pelvic floor disorders treatments
  • Sleep and Wakefulness Research
  • Ocular and Laser Science Research
  • Acne and Rosacea Treatments and Effects
  • Glycosylation and Glycoproteins Research
  • Proteoglycans and glycosaminoglycans research
  • Surfactants and Colloidal Systems

University of Alabama at Birmingham
2015-2024

Wellcome/Cancer Research UK Gurdon Institute
2022

Africa Center
2022

University of Alabama
2017-2020

Kala Pharmaceuticals (United States)
2020

Johnson & Johnson (Israel)
2020

Johnson & Johnson (United States)
2013-2019

Alcon (United States)
2019

University of Rochester
2018

Association for Research in Vision and Ophthalmology
2018

The purpose of this report was to examine the relation between clinical tests and dry eye symptoms in patients with disease.Seventy-five disease (ICD-9 code 375.15) were included these analyses. There no specific entry criterion for enrollment addition a previous diagnosis clinic-based sample. Patients represented varying types severity previously diagnosed by clinic attending doctors university setting. study examination symptom interview that assessed dryness, grittiness, soreness,...

10.1097/01.ico.0000133997.07144.9e article EN Cornea 2004-10-21

To examine tear film, contact lens, medical, and patient-related factors associated with self-reported lens-related dry eye.Four hundred fifteen lens wearers were recruited enrolled in this phase of a larger cross-sectional study. A variety film (e.g., interferometry, osmolality, phenol red thread, meibography, fluorescein, lissamine green staining), (i.e., water content, refractive index, material), gender, sociodemographic, education, income, medical health) examined relation to eye...

10.1167/iovs.05-1392 article EN Investigative Ophthalmology & Visual Science 2006-03-24

Purpose: To determine the frequency of and factors associated with contact lens dissatisfaction discontinuation. Methods: A cross-sectional survey 730 subjects was conducted using a self-administered instrument. The collected information about present age sex, history wear, types lenses worn, at starting current wearing schedule (hours per day, days week), self-perceived satisfaction, lens-related problems. variety statistical analyses including analysis variance, logistic regression,...

10.1097/01.ico.0000248382.32143.86 article EN Cornea 2007-02-01

While clinicians practicing in the area of contact lenses all are familiar with CLD, a variety terms and verbiage have been used to describe this problem.Typically these patients present symptoms ocular discomfort some sort (e.g., dryness, irritation, discomfort, fatigue, so forth), it is common

10.1167/iovs.13-13212 article EN Investigative Ophthalmology & Visual Science 2013-09-20

FIGURE.Plot of median end-of-day comfort from Brennan and Coles 116,117 versus coefficient friction reported by Ross colleagues 118 (open circles, dashed line, scale above plot area) Roba 115 (closed unbroken below area).

10.1167/iovs.13-13215 article EN Investigative Ophthalmology & Visual Science 2013-09-21

Purpose Orthokeratology is defined as the temporary reduction in myopia by programmed application of rigid gas-permeable contact lenses. New reverse geometry lens designs and materials have led to a renewed interest this field. The purpose study assess visual, refractive, topographic, corneal thickness changes subjects undergoing overnight orthokeratology. Methods Ten myopic (mean age, 25.9 ± 3.9 years) were recruited for 60-day trial orthokeratology using After commencing wear, examined on...

10.1097/00006324-200005000-00012 article EN Optometry and Vision Science 2000-05-01

The lipid layer of the tear film forms a barrier to evaporation. Evaporation is major cause thinning between blinks and breakup. purpose this study was investigate relation thickness before after instillation an emulsion eye drop.Fifty non-contact lens wearers were studied. Spectral interferometry used measure rate precorneal for up 19 seconds blink. Simultaneously, measured based on absolute reflectance spectrum. After 2-minute recovery, measurement repeated. A drop then instilled; 15...

10.1167/iovs.09-4387 article EN Investigative Ophthalmology & Visual Science 2010-03-16

purpose. To apply interferometry as an in vivo measure of tear film thinning between blinks. methods. Wavelength-dependent interference was used to the rates 20 normal contact lens wearers, and spectra were captured at a rate 4.5 per second for seconds. Four recordings precorneal (PCTF) made, followed by 1 hour hydrogel wear then four prelens (PLTF) thinning. Subjects asked blink after beginning recording hold their eyes open additional 19 seconds, 2 minutes rest recordings. results. The...

10.1167/iovs.05-0094 article EN Investigative Ophthalmology & Visual Science 2005-06-24

The Ocular Surface Disease Index (OSDI) is a 12-item scale for the assessment of symptoms related to dry eye disease and their effect on vision. Its reliability validity have been investigated within classical test theory framework and, more recently, using Rasch analysis. purpose present analysis was completely investigate functioning its response category structure, three subscales, unidimensionality latent construct it intended assess.Responses OSDI from 172 females participating in Dry...

10.1167/iovs.11-8027 article EN Investigative Ophthalmology & Visual Science 2011-09-26

To analyze relations between upper lid (UL) and lower (LL) meibomian gland (MG) morphology tear film the MG criteria ability to predict dry eye.MG, lipid layer, non-invasive break-up time (NIBUT) were evaluated of OD 20 randomly selected subjects (female = 10; median age 44.5 years, interquartiles 39.5 55 years). Subjects grouped into nine Ocular Surface Disease Index (OSDI)- 11 OSDI+ by OSDI. Non-contact infrared meibography image analysis performed evaluate loss, thickness, bent angle.MG...

10.1097/opx.0b013e318244e487 article EN Optometry and Vision Science 2012-01-13
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