A5100364555- Nutrition and Health in Aging
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastric Cancer Management and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Balance, Gait, and Falls Prevention
- Antimicrobial Peptides and Activities
- Pluripotent Stem Cells Research
- Vestibular and auditory disorders
- Body Composition Measurement Techniques
- Hearing, Cochlea, Tinnitus, Genetics
- Frailty in Older Adults
- Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- Lipoproteins and Cardiovascular Health
- Neuroscience and Neuropharmacology Research
- Musculoskeletal pain and rehabilitation
- Endoplasmic Reticulum Stress and Disease
Nanjing Medical University
2021-2025
Jiangsu Province Hospital
2021-2025
Cangzhou Central Hospital
2022-2024
Tianjin Medical University
2017-2024
Rockefeller University
2024
Zhongda Hospital Southeast University
2024
Chongqing Jiaotong University
2023-2024
University of Electronic Science and Technology of China
2024
First Affiliated Hospital of Jinan University
2019-2024
Shanghai Jiao Tong University
2012-2023
Arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) produces dramatic remissions in patients with relapsed or refractory acute promyelocytic leukemia. Its clinical use is burdened by QT prolongation, torsade de pointes, and sudden cardiac death. In the present study, we analyzed molecular mechanisms leading to As<sub>2</sub>O<sub>3</sub>-induced abnormalities of electrophysiology. Using biochemical electrophysiological methods, show that long-term exposure As<sub>2</sub>O<sub>3</sub> increases...
Abstract Background Macrophage polarization and reprogramming in the lung play a critical role initiation, development progression of acute injury (ALI). Regulating activation differentiation pulmonary macrophages may provide potential therapeutic strategy to treat ALI. We previously developed novel class anti-inflammatory nanoparticles (P12) that can potently inhibit Toll-like receptor (TLR) signaling macrophages. These bioactive nanodevices were made gold (GNPs) coated with hexapeptides...
Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common life‐threatening with no effective pharmacotherapy. Sepsis‐related ARDS the main type of and more fatal than other types. Extracellular vesicles (EVs) are considered novel mediators in development inflammatory diseases. Our previous research suggested that endothelial cell‐derived EVs (EC‐EVs) play crucial role ALI/ARDS development, but mechanism remains largely unknown. Here, we demonstrated number...
The development of acute respiratory distress syndrome (ARDS) in sepsis is associated with substantial morbidity and mortality. However, the molecular pathogenesis underlying sepsis-induced ARDS remains elusive. Neutrophil heterogeneity dysfunction contribute to uncontrolled inflammation patients ARDS. A specific subset neutrophils undergoing reverse transendothelial migration (rTEM), which characterized by an activated phenotype, implicated systemic dissemination inflammation. Using...
Metabolic disorder significantly contributes to diabetic vascular complications, including retinopathy, the leading cause of blindness in working-age population. However, molecular mechanisms by which disturbed metabolic homeostasis causes dysfunction retinopathy remain unclear. O-GlcNAcylation modification acts as a nutrient sensor particularly sensitive ambient glucose. Here, we observe pronounced O-GlcNAc elevation retina endothelial cells patients and mouse models. Endothelial-specific...
Abstract Bio/artificial hybrid nanosystems based on biological matter and synthetic nanoparticles (NPs) remain a holy grail of materials science. Herein, inspired by the well‐defined metal–organic framework (MOF) with diverse chemical diversities, concept “armored red blood cells” (armored RBCs) is introduced, which are native RBCs assembled within protected functional exoskeleton interlinked MOF NPs. Exoskeletons generated seconds through NP interlocking metal‐phenolic coordination RBC...
Abstract Background Uncontrolled inflammation is a central problem for many respiratory diseases. The development of potent, targeted anti-inflammatory therapies to reduce lung and re-establish the homeostasis in tract still challenge. Previously, we developed unique nanodrug, P12 (made hexapeptides gold nanoparticles), which can attenuate Toll-like receptor-mediated inflammatory responses macrophages. However, effect administration route on its therapeutic efficacy tissue distribution...
Objective To investigate the associations between cognition, anxiety, depression, and residual dizziness after successful repositioning maneuvers in elderly with benign paroxysmal positional vertigo (BPPV). Methods We enrolled 40 patients BPPV our outpatient department. used Dizziness Handicap Inventory (DHI), Visual Analog Scale (VAS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Questionnaire-7 (GAD-7) to assess degree of dizziness, depression participants before...
Assessment of the association muscle strength and mass with osteoporosis (OP) is special interest as muscles are a potential target for interventions (i.e., training). A cross-sectional descriptive study encompassing people aged ≥ 60 years (average age: 66.9 ± 6.2 years; men, n = 516; women, 652) in Hangu area Tianjin, China. The populations were invited to participate comprehensive geriatric assessment. OS was identified by measuring calcaneal using quantitative ultrasound T score less than...
Overwhelming uncontrolled inflammation is the hallmark of pathophysiological features many acute and chronic inflammatory diseases, such as sepsis allergy autoimmune disorders. It important to develop potent pharmacological interventions effectively control detrimental reactions in these diseases. Recently, we have developed a special class peptide-gold nanoparticle hybrid system that can inhibit Toll-like receptor 4 (TLR4) signal transduction pathways decrease its downstream responses....
Pten plays a crucial role in the stem cell maintenance few organs. defect also causes premature oocytes and ovary aging. We other groups have found that phosphatidylinositol-3-OH kinase (PI3K)-Akt signaling regulates proliferation differentiation of spermatogonial cells (SSCs). PTEN functions as negative regulator PI3K pathway. Thus, we thought fate SSCs might be controlled by Pten.We report promyelocytic leukaemia zinc finger (PLZF) undifferentiated embryonic transcription factor 1 (UTF1),...
Abstract High‐dose ionizing radiation can lead to death from the unrecoverable damage of gastrointestinal tract, especially small intestine. Until now, lack predilection for intestine and rapid clearance by digestive fluids limit effects conventional radioprotective formulations. Herein, an innovative strategy is developed attenuating syndrome smart oral administration nanodrugs. The nanodrug first engineered encapsulating thalidomide into chitosan‐based nanoparticles, then coated with...
The objective of this study was to determine falls risk profiles derive a prediction score and establish simple practical clinical screening tool for Chinese community-dwelling elderly individuals. This prospective cohort (n = 619) among adults aged 60 years older. Falls were ascertained at 1-year follow-up appointment. Sociodemographic information, medical history, physical performance data collected. mean age 67.4 years; 57.7% women. Female sex (odds ratios [ORs] 1.82; 95% confidence...
Objective: To explore the neurotoxicity and mechanism of tris(2-chloroethyl) phosphate (TCEP) exposure in mice.Methods: Total 30 adult Kunming mice were randomly divided into normal control group (0 mg/kg·d), low-dose TCEP (10 high-dose (100 administered continuously by gavage for days.Results: Compared with group, water intake was declined significantly (p < 0.05), organ index liver spleen increased 0.05). In addition, escape latency exposed longer than that maze test while total swimming...