A5059078303- Plant Pathogens and Resistance
- Plant Disease Resistance and Genetics
- Plant-Microbe Interactions and Immunity
- Nitrogen and Sulfur Effects on Brassica
- Plant Pathogens and Fungal Diseases
- Plant tissue culture and regeneration
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Plant Disease Management Techniques
- Regional Development and Environment
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Plant Genetic and Mutation Studies
- Estrogen and related hormone effects
- Microscopic Colitis
- Inflammatory Bowel Disease
- Protein Tyrosine Phosphatases
- Agricultural Science and Fertilization
- Food Supply Chain Traceability
- Plant Growth Enhancement Techniques
- PI3K/AKT/mTOR signaling in cancer
- Mycobacterium research and diagnosis
- Rice Cultivation and Yield Improvement
- Listeria monocytogenes in Food Safety
Directorate of Rapeseed-Mustard Research
2013-2025
Amity University
2016-2024
Chaudhary Charan Singh Haryana Agricultural University
2024
University of Illinois Chicago
2024
National Institute of Abiotic Stress Management
2024
Apotex (India)
2023
Post Graduate Institute of Medical Education and Research
2019-2023
Patna University
2019
Spectrum Pharmaceuticals (United States)
2016
Babasaheb Bhimrao Ambedkar University
2015
India is the largest agrarian subcontinent supporting 26% world’s agricultural population on 12% arable land. also fifth vegetable oil economy accounting 7.4% oilseeds, 5.8% oils and 6.1% meal production, 9.3% of edible consumption in world. Oilseeds are second most important next to cereals growing at a pace 4.1% per annum last three decades. Oilseed brassica shares 23.5% area 24.2% production total oilseeds country. Despite being third producer (11.3%) oilseed after Canada China world,...
The relative importance of genotype and explant, their interactions for in vitro plant regeneration via both organogenesis somatic embryogenesis Solanum melongena (eggplant) has been studied. Hypocotyl, cotyledon leaf explants four commercially grown Indian cultivars, Pusa Purple Long, Long White Cluster, Kranti, Cluster were used the study. A combination benzyladen-ine (11.1 μM) indoleacetic acid (2.9 was found to be optimum shoot regeneration. Naphthalene acetic induced all three explants;...
Prostate cancer (PCa) cells expressing full-length androgen receptor (AR-FL) are susceptible to deprivation therapy (ADT). However, outgrowth of castration-resistant prostate (CRPC) can occur due the expression constitutively active (ligand-independent) AR splice variants, particularly AR-V7. We previously demonstrated that sulforaphane (SFN), an isothiocyanate phytochemical, decrease AR-FL levels in PCa cell lines, LNCaP and C4-2B. Here, we examined efficacy SFN targeting both AR-V7 CRPC...
Mast cells (MCs) are found in increased numbers at airway mucosal surfaces asthmatic patients. Because human epithelial (HAECs) actively participate inflammatory responses and direct contact with MCs the mucosa, we hypothesized that HAEC-MC interactions may contribute to differentiation survival of mucosa. Here, show HAECs express mRNA protein for soluble membrane-bound stem cell factor, releasing factor into culture supernatant a concentration 5.9 ± 0.1 ng per 10 6 HAEC. were able support...
Objective The amino-terminal polymorphisms, Arg16Gly and Gln27Glu, of the β2-adrenergic receptor (β2AR) have been shown to affect regulation expression by an agonist in cell culture studies. polymorphism has also recently be associated with essential hypertension. We therefore evaluated whether polymorphisms β2AR are hypertension a Caucasian population. Subjects methods performed association study 298 hypertensive patients equal number age-matched normotensive controls from East Anglian...
Tumorigenic potential of glioblastoma multiforme (GBM) cells is, in part, attributable to their undifferentiated (neural stem cell-like) phenotype. Astrocytic differentiation GBM is associated with transcriptional induction Glial Fibrillary Acidic Protein (GFAP) and repression Nestin, whereas the reciprocal transcription program operates cells. The molecular mechanisms underlying regulation these programs remain elusive. Here, we show that co-activator p300 was expressed tumors cell lines...
Prostate cancer (PCa) cells utilize androgen for their growth. Hence, deprivation therapy (ADT) using anti-androgens, e.g. bicalutamide (BIC) and enzalutamide (ENZ), is a mainstay of treatment. However, the outgrowth castration resistant PCa (CRPC) remains significant problem. These CRPC express receptor (AR) intratumoral towards continued growth invasion. Sulforaphane (SFN), naturally occurring isothiocyanate found in cruciferous vegetables, can decrease AR protein levels. In present study,...
Abstract Milk is globally consumed as a rich source of protein and calcium. A major component milk casein, with β-casein having 2 variants A1 A2. Of these, casein variant has been implicated potential etiological factor in several pathologies, but direct effect on lungs not studied. The objective the present study was to evaluate A1and A2 β cow factors causing allergic airway disease murine model. Mice fed A1A1 exhibited increased hyperresponsiveness increasing concentration...
White rust caused by Albugo candida, an oomycete pathogen, is a devastating disease of Brassica juncea (Indian mustard) worldwide. There need to screen virulent white isolates challenge the developed rust–resistant B. cultivars their resistance potential. The current study explores pathogenic and biochemical response Indian mustard collected from three different geographic locations India. observations refine our understanding severity in Disease progression responses were studied...
The Mayo endoscopic score (MES) remains the most commonly used index in clinical practice, as well various trials. Recently, two validated histological indices (Nancy Index [NI] and Robert Histological [RHI]) have been developed for ulcerative colitis (UC). We aim to study relationship between MES with NI, RHI, established Geboes (GI) patients UC.This was a prospective single-center study. documented from involved area. Biopsy taken same area reported by single gastrointestinal...
In response to interleukin-4 (IL-4) or IL-13 stimulation of cells, Stat6 becomes phosphorylated on Tyr641 and forms homodimers that migrate the nucleus, bind cognate DNA elements, drive transcription target genes. Here, we show phosphorylation multiple serine residues ablates its DNA-binding activity in IL-4 stimulated cells. The sites are mapped transactivation domain (TAD) Stat6. Importantly, TAD does not affect Tyr641, nor it dimer formation ability translocating nucleus IL-4-stimulated...