A5038886895- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Monoclonal and Polyclonal Antibodies Research
- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Natural Antidiabetic Agents Studies
- Glycosylation and Glycoproteins Research
- Mycotoxins in Agriculture and Food
- Dermatology and Skin Diseases
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Venomous Animal Envenomation and Studies
- Psidium guajava Extracts and Applications
- Pregnancy and preeclampsia studies
- Bee Products Chemical Analysis
- Meat and Animal Product Quality
- Pharmacological Effects of Medicinal Plants
- Galectins and Cancer Biology
- Hydrogels: synthesis, properties, applications
- Advanced biosensing and bioanalysis techniques
- Fungal Infections and Studies
- Marine Invertebrate Physiology and Ecology
- Folate and B Vitamins Research
Lala Lajpat Rai University of Veterinary and Animal Sciences
2024
Bhabha Atomic Research Centre
1982-2023
Aligarh Muslim University
2022
University of Ulster
2018-2021
Universitatea Națională de Știință și Tehnologie Politehnica București
2021
Hesco (United States)
2020
Dr. A.P.J. Abdul Kalam Technical University
2015
National Botanical Research Institute
2014
Jodhpur National University
2013
University of Delhi
2008
Solid lipid nanoparticle is an efficient based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz a highly lipophilic from nonnucleoside inhibitor category for treatment HIV. Present work illustrates development SLN formulation with increased bioavailability. At first, suitable component and surfactant were chosen. SLNs prepared analyzed physical parameters, stability, pharmacokinetic profile. loaded formulated using Glyceryl monostearate as...
Abstract Background Maternal folic acid (FA) supplementation before and in early pregnancy prevents neural tube defects (NTD), but it is uncertain whether continuing FA after the first trimester has benefits on offspring health. We aimed to evaluate effect of throughout cognitive performance brain function child. Methods Follow-up investigation 11-year-old children, residing Northern Ireland, whose mothers had participated a randomised trial Folic Acid Supplementation Second Third Trimesters...
A specific microtest plate enzyme immunoassay has been developed for the rapid quantitation of aflatoxin B1 at levels as low 25 pg per assay. Multiple-site injection rabbits with an carboxymethyloxime-bovine serum albumin conjugate was used production hyperimmune sera. Dilutions purified antibody were air dried onto microplates previously treated bovine and glutaraldehyde then incubated carboxymethyloxime-horseradish peroxidase conjugate. The amount bound to determined by monitoring change...
Abstract Background Biosensors are tools that products of amalgamation biological constituents and physicochemical elements so as to detect analytes, based on signal production which is measurable. Thus here we can see an assimilation biology microelectronics. Keeping a track biochemical processes in human system essential; thus, there increasing need for extremely sensitive economical devices make precise diagnosis personalised medication treatment possible. Objective This review focuses...
Diclofenac sodium loaded solid lipid nanoparticles (SLNs) were formulated using guggul as major component and analyzed for physical parameters, permeation profile, anti-inflammatory activity. The SLNs prepared melt-emulsion sonication/low temperature-solidification method characterized in vitro drug release, accelerated stability studies, into gel. Respective gels compared with a commercial emulgel (CEG) plain carbopol gel containing (CG) ex vivo stable optimum parameters. GMS nanoparticle 1...
This study was aimed at preparing and characterizing solid lipid nanoparticles (SLNs) of donepezil (DPL) for delivery to brain via nasal route. SLNs were prepared by solvent emulsification diffusion technique using glyceryl monostearate (GMS) as blend tween 80 poloxamer 188 (1:1) surfactant. Box–Behnken design applied optimization drug ratio, surfactant concentration stirring time dependent variables their effect observed on particles size, entrapment efficiency loading. Optimized...
Lymphatic route is one of the prominent routes for improving poor bioavailability drugs which undergo extensive hepatic first pass metabolism. Nanocarriers (solid lipid nanoparticles) offer a new drug delivery system that could hold great promise attaining enhancement along with controlled and site specific delivery.The aim present research work was to prepare optimized Quetiapine fumarate (an antipsychotic drug) loaded solid nanoparticles lymphatic targeting through intraduodenal...
Gabapentin follows saturation kinetics for absorption because of carrier-mediated transport and narrow window in stomach. There is need to develop a gastroretentive formulation maximize the without crossing threshold absorption.The aim was gabapentin increase fraction drug absorbed stomach.Sodium alginate sodium carboxymethylcellulose were used formulate microsphere by ionotropic gelation with calcium chloride. The optimized using three-factor, three-level Box-Behnken design.The particle...
: The human body is almost 70% water and fluid imbalance has been a classic symptom of severe underlying conditions, i.e., hepatic disorders, kidney cardiovascular disease inflammation. Boerhavia diffusa Linn. pantropical herb used in traditional medicine systems worldwide for inflammation, liver-kidney skin problems, etc. Ethnopharmacological reports B. correlate well with its uses. roots leaves have demonstrated diverse pharmacological activities in-vitro in-vivo studies. It occurs Asia,...
The specificity and sensitivity of antiserum elicited from rabbits against aflatoxin B2a-bovine serum albumin conjugates were characterized with a radioimmunoassay (RIA) an enzyme-linked immunosorbent assay (ELISA). Aflatoxin B1 was first converted to B2a then conjugated bovine horseradish peroxidase by reductive alkylation method. developed in New Zealand white multiple-site injection the conjugate. Antibody titers determined both RIA ELISA. Competitive RIAs various analogs indicated that...
Praveen Kumar Gaur*a, Suresh Purohitb, Yatendra Kumarc, Shikha Mishrad & Anil Bhandariea Department of Pharmaceutics, Jodhpur National University Jodhpur, RajasthanIndiab Pharmacology, IMS-BHU Varanasi, Uttar PradeshIndiac Pharmaceutical Chemistry, I.T.S. Paramedical (Pharmacy) College Muradnagar, Ghaziabad, PradeshIndiad Pharmacognosy Phytochemistry Jamia Hamdard, New DelhiIndiae RajasthanIndia
Curcumin is an important anti-inflammatory natural compound with low bioavailability which due to poor solubility and absorption. Solid lipid nanoparticles (SLNs) loaded were formulated evaluated for physical parameters in vitro/ex vivo permeation. Further the optimised SLN was assessed pharmacokinetic/pharmacodynamic considerations. SLNs by emulsion-solvent evaporation technique properties vitro drug release. Selected stability then characterised pharmacokinetic activity reference a...
Certain mechanism like presence of highly complex structure i.e. blood brain barrier (BBB), P-glycoprotein (active efflux transporter) and certain enzymatic activity protect the in adverse conditions. These mechanisms especially BBB frustrate therapeutic interventions during treatment. As a result most drug substances are fruitless treating disorders, because they not able to reach desired amount required for activity. consequence, several invasive non-invasive strategies presently being...