A5005027706- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Additive Manufacturing and 3D Printing Technologies
- Pharmacological Effects of Natural Compounds
- Bee Products Chemical Analysis
- Biochemical effects in animals
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Cholinesterase and Neurodegenerative Diseases
- Aluminum Alloys Composites Properties
- Silymarin and Mushroom Poisoning
- Wound Healing and Treatments
- Medicinal Plants and Neuroprotection
- Curcumin's Biomedical Applications
- Alzheimer's disease research and treatments
- Advanced Biosensing Techniques and Applications
- Ferrocene Chemistry and Applications
- Calpain Protease Function and Regulation
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Feminism, Gender, and Social Issues
- Nephrotoxicity and Medicinal Plants
- Neurological Complications and Syndromes
Institute of Management Technology
2009-2024
Hesco (United States)
2020
Banaras Hindu University
2011
Institute of Medical Sciences
2011
Duke University
2007
University of Maryland, Baltimore
2005
Abstract Background Biosensors are tools that products of amalgamation biological constituents and physicochemical elements so as to detect analytes, based on signal production which is measurable. Thus here we can see an assimilation biology microelectronics. Keeping a track biochemical processes in human system essential; thus, there increasing need for extremely sensitive economical devices make precise diagnosis personalised medication treatment possible. Objective This review focuses...
In the realm of composite manufacturing, this study delves into innovative approach enhancing Aluminum-Based Composite Manufacturing through Si3N4 Reinforcement leveraged via Friction Stir Process (FSP). The FSP technique, executed with precision using a vertical milling machine, intricately fabricates materials unparalleled properties. Meticulously chosen parameters including pin diameter, tool tilt angle, and profile, coupled precise traversal rotation, define operation. substrate,...
Parkinson disease is a neurodegenerative disorder characterised by the cardinal symptoms of stiffness, resting tremor, slowness (bradykinesia) and reduction movement (hypokinesia). Involvement oxidative damage has been reported in pathophysiology its related complications. The purpose this study was to examine effect daidzein quench free radicals produced as result increased stress disease.Parkinson induced administration reserpine (5 mg/kg/day, i.p) for 5 consecutive days. PD such tremors,...
The current study was conducted to examine the possible advantages of Heydotis corymbosa (L.) Lam. extract nanogel as a perspective for enhanced permeation and extended skin deposition in psoriasis-like dermatitis. Optimised nanophytosomes (NPs) were embedded pluronic gel base obtain tested ex vivo (skin penetration dermatokinetics) vivo. optimised NPs had spherical form entrapment efficiency 73.05 ± 1.45% with nanosized zeta potential 86.11 nm −10.40 mV, respectively. Structural evaluations...
<b>Objective:</b> The present study describes the effect of nebivolol (NBV) either alone or in combination with lamotrigine (LTG) using increasing current electroshock seizures (ICES) model mice.<br><b> Materials and Methods:</b> Male albino mice Swiss strain each weighing 18-30 g were used. Lamotrigine (Lamitor tablets, Torrent; 1.5 3.0 mg/kg) NBV (Nebicard 0.25 0.5 suspended 0.25% carboxy methyl cellulose (CMC) 0.9% saline administered orally volumes 10 mg/kg. Control animals received an...
Epilepsy is one of the most common and severe brain disorders in world, characterized by recurrent spontaneous seizures due to an imbalance between cerebral excitability inhibition. Oxidative stress a biochemical state which reactive oxygen species are generated associated with various diseases including epilepsy. Pycnogenol, polyphenol obtained from pine tree has antioxidant & anti-inflammatory activity. So, aim study was evaluate effect Pycnogenol on pentylenetetrazole (PTZ)-induced...
Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects roots Rubia cordifolia L. (R. L.) in Wistar rat model for diabetic and possible neuroprotective, antidiabetic, analgesic mechanisms underlying this effect.Rats were divided into five experimental groups. An amount 0.25% carboxy methyl cellulose (CMC) saline streptozotocin (STZ) (60 mg/kg) was given to group 1 2, respectively. Group 3 treated with STZ glibenclamide...
Neuropathic pain is a severe and unbearable condition which arises due to activation of peripheral nociceptors after tissue damage, neuropathic caused from anomalous physiology central or nervous system it may not be related the ongoing damage inflammation. Involvement oxidative has been reported in pathophysiology pain. The purpose this study was examine effect lycopene quench free radicals produced as result increased stress induced wistar rats by partial sciatic nerve ligation. evaluated...
This study explores the advancement of aluminum-based composites through integration fly ash and silicon carbide (SiC) reinforcement via stir casting. The process involves melting alloy in a crucible within muffle furnace at 700°C, gradually introducing SiC particles while stirring 450 rpm for 12 minutes to ensure uniform dispersion. addition 5% 2.5% led significant improvements multiple mechanical properties.Tensile strength experienced remarkable enhancement approximately 19.56%, hardness...
This study aimed to develop a delivery system for the dried aqueous extract of Rubia cordifolia leaves (RCE) that could improve neuroprotective potential RCE by improving bioavailability chief chemical constituent rubiadin. Rubiadin, an anthraquinone chemically, is biomarker phytoconstituent RCE. Rubiadin reported have strong antioxidant and activity but demonstrates poor bioavailability. In order resolve problem related bioavailability, phospholipids were reacted in disparate ratios 1:1,...
Background: Doxorubicin (DOX) is a widely used chemotherapeutic agent that effective against various solid tumors and hematologic malignancies. However, its clinical application severely limited by dose-dependent cardiotoxicity, which affects nearly 26% of patients. Objective: This review focuses on recent insights into the molecular mechanisms DOX-induced particularly highlighting roles oxidative stress mitochondrial dysfunction. Methods: We have reviewed retrieved relevant information...
In the realm of mechanical engineering, adoption and integration cutting-edge technologies promise unprecedented advancements in material science production processes. This paper delves into pioneering Advanced Composite Manufacturing leveraging both Additive (AM) Robotic Techniques. Exploiting intrinsic merits AM, such as enhanced design freedom, reduced lead times, intricate detailing, research synergizes these advantages with precision, speed, repeatability offered by robotic mechanisms....
Pitavastatin is a competitive HMG-CoA reductase inhibitor for lowering of cholesterol level and low density lipoprotein cholesterol. This study was designed to evaluate the effect pitavastatin in neuropathic pain induced by partial sciatic nerve ligation along with neuronal changes Wister rats.Pitavastatin started three days prior surgery continued 14 The determined thermal hyperalgesia cold allodynia. biochemical were estimated at end study. levels cytokines measured using an ELISA test....
The study was aimed to encapsulate Hedyotis corymbosa extract (HCE) into phytosomes improve its therapeutic efficacy in neuropathic pain by enhancing the bioavailability of chief chemical constituent Hedycoryside -A (HCA).For preparing complexes (F1, F2, and F3), HCE phospholipids were reacted disparate ratio. F2 chosen assess induced partial sciatic nerve ligation. Nociceptive threshold oral also estimated for F2.Particle size, zeta potential entrapment efficiency analysed as 298.1 ± 1.1...
The current research work focuses mainly on evolving a delivery system for ginseng extract (GE), which in turn will ameliorate the neuroprotective potential through enhancing Ginsenoside Rb1(GRb1) bioavailability (BA). Phytosome complexes (F1, F2, and F3) were prepared by reacting GE with phospholipids disparate ratios. F3 was chosen preparing phytosomes powder (PP) phytosomes-loaded microspheres (PMs). Extract (EMs) addition of directly into same polymer mixture. gave enhanced entrapment...