The Pipper nigram (P. nigram) leaf extract was used for the biosynthesis of copper oxide nanoparticles (CuO NPs) and successful formation resultant product confirmed through several physicochemical techniques. chemical structure elemental composition were analysed Fourier transform infrared (FTIR) energy dispersive X-ray (EDX) spectroscopies, respectively. crystalline crystallite size investigated an diffractometer (XRD) a monoclinic with 40.68 nm reported. Even-distributed particles average...

Essential oils (EOs) are chemical products produced by odoriferous glands from a variety of plants. These essential have many health benefits: antiseptic, anti-inflammatory and antimicrobial activities. So due to these medicinal properties, the present study was designed analyze Thymus zygis L. willdenowii Boiss. for their composition biological two thyme species were collected region Ifrane, Middle Atlas Morocco. The EO obtained hydrodistillation, yields 5.25% T. 3.00% willdenowii. EOs...

Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, characteristic polyphenols citrus species, are primarily compounds responsible these health benefits. Using silico vitro methods, we exploring possible antidiabetic action narirutin, a flavanone family member. The goal research was to anticipate how narirutin would interact with eight distinct receptors implicated diabetes control complications, namely,...

The study of bioactive molecules natural origin is a focus current research. Thymus algeriensis and Artemisia herba-alba are two medicinal plants widely used by the Moroccan population in traditional treatment several pathologies linked to inflammation. This aimed evaluate single combined antioxidant, anti-inflammatory analgesic effects essential oils extracted from these plants, also their potential toxicity. Essential were using hydro-distillation Clevenger-type apparatus. antioxidant...

Centaurea parviflora (C. parviflora), belonging to the family Asteraceae, is an Algerian medicinal plant used in folk medicine treat different diseases related hyperglycemic and inflammatory disorders, as well food. The present study aimed assess total phenolic content, vitro antioxidant antimicrobial activity phytochemical profile of extracts C. parviflora. extraction compounds from aerial parts was conducted using solvents increasing polarity starting methanol, resulting crude extract...

In the current study, effects of enhancing semen quality, brain neurotransmitters, and antioxidant status in rabbits under heat stress with acacia gum, vitamin C, lycopene as dietary supplements were estimated vitro silico. A total 40 males from New Zealand White aged 3 months equally divided into four groups (n = 10). The first group was a control. other three (oral 100 mg/kg body weight), ascorbic acid (30 (50 weight). All showed physical characteristics terms increasing sperm motility,...

This study focused on developing new inhibitors for the MCF-7 cell line to contribute our understanding of breast cancer biology and various experimental techniques. 3D QSAR modeling was used design tetrahydrobenzo[4, 5]thieno[2, 3-d]pyrimidine derivatives with good characteristics. Two robust 3D-QSAR models were developed, their predictive capacities confirmed through high correlations [CoMFA (Q 2 = 0.62, R 0.90) CoMSIA 0.71, 0.88)] via external validations (R ext 0.90 0.91, respectively)....

Saussurea costus (Falc) Lipsch is a traditional herb used to treat kidney stone problems because it contains several molecules this health problem, such as quercitrin. Infectious stones are the most painful of all urinary tract disorders, with ammonium phosphate (struvite) and carbapatite being common, caused by bacterial infection urease activity. These treated antibiotics, but antibiotic resistance on rise. The current study investigated anti-urolithic activities S. aqueous ethanolic...

Introduction: Increased mortality owing to breast and lung cancer is an urgent global medical issue. Nanotherapy one of the most widely used recent procedures for combating cancer. Therefore, this study aimed assess beneficial effects multi-walled carbon nanotubes (MWCNTs) precisely target (MCF-7) (A549) cell lines. Multi-walled nanomaterials are considered as a typical biocompatible nanomaterial that can be in drug delivery without causing side effects. On contrary, metallic nanoparticles,...

Diabetic neuropathy is a debilitating manifestation of long-term diabetes mellitus. The present study explored the effects roots Rubia cordifolia L. (R. L.) in Wistar rat model for diabetic and possible neuroprotective, antidiabetic, analgesic mechanisms underlying this effect.Rats were divided into five experimental groups. An amount 0.25% carboxy methyl cellulose (CMC) saline streptozotocin (STZ) (60 mg/kg) was given to group 1 2, respectively. Group 3 treated with STZ glibenclamide...

Abstract Dengue virus (DENV) infection is one of the diseases for which no drug available treatment. The DENV NS2B-NS3 protease considered to be prime target anti-dengue development because its importance in new subunits via poly-protein breakdown. Pentacyclic triterpenoids (Lantadenes) from weed Lantana camara L. and semi-synthetic congeners have shown a wide array biological activities last two decades. virtual screening strategy was used on library 78 natural lantadenes predict potent...

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) virus, is a highly contagious with widespread societal impact. symptoms range from cough, fever, and pneumonia to complications affecting various organs, including heart, kidneys, nervous system. Despite ongoing efforts, no effective drug has been developed stop spread of virus. Although types medications used treat bacterial viral diseases have previously employed COVID-19 patients, their...

The effects of pharmaceutical under aquatic biota are still not well established. In this investigation, we assessed the results a common pharmaceutical's, triclosan (TCS), treatment on physiological and biochemical status Mediterranean mussels. Filtration respiration rates were statistically reduced after with highest considered concentration TCS2 = 100 µg·L-1. However, no modification (p > 0.05) was detected TCS1 50 For responses, oxidative stress parameters including H2O2 level...

This study aims to evaluate the toxicity of ZnS nanoparticles (ZnS NP50 = 50 µg/L and NP100 100 µg/L) diethyl (3-cyano-1-hydroxy-2-methyl-1-phenylpropyl)phosphonate or P (P50 P100 in clams Ruditapes decussatus using chemical biochemical approaches. The results demonstrated that accumulate NPs other metallic elements following exposure. Moreover, separately lead ROS overproduction, while a mixture both contaminants has no effect. In addition, data showed exposure resulted increased levels...

Plants continue to play a critical role in the discovery of effective compounds, especially anticancer drugs. Abutilon pannosum has been historically used as therapeutic plant medicinal system. In this study, an ethanolic crude extract was prepared from dried powder A. and subsequently fractionated produce chloroform, butanol, water fractions. The fractions were tested for their cytotoxic action against various cancer cells using MTT assay. Additionally, effect most promising fraction on...

Abstract Multiple beneficial effects have been reported to numerous species of Capparis genus. Among these, spinosa has exhibited several biological benefits, including anti-inflammatory hepatoprotective, antioxidant, and antidiabetic effects. Herein, C. was extracted with different solvents the ability these fractions suppress nitric oxide (NO) production in RAW 264.7 cells were assessed via Griess reagent. The on inflammatory markers also determined THP-1 Human umbilical vein endothelial...

Abstract Cancer is the second largest cause of mortality worldwide. Many natural bioactive chemicals generated from plants have favorable impacts on health, including cancer chemoprevention, compared to their manufactured counterparts. Persicaline, a novel sulfur-containing imidazoline alkaloid derived Salvadora persica , has been shown display promising antioxidant activity. In this study, antiproliferative activity persicaline was tested against different cells using...

This experiment was designed to investigate and compare the egg production, fertility, hatchability immune responses of some local developed Egyptian chicken strains under high ambient temperatures. A total 108 (26 weeks old) laying hens Matrouh, Silver Montazah, Mandarah Inshas (9 × 3 replicates 4 strains) were used evaluate impact thermal stress (24-34ºC) during summer season (June, July August) on responses. The obtained results revealed that final body weight (FBW/g) change (BWC/g) among...