Withania frutescens L. is a wild perennial woody plant used by the local population for diverse therapeutic purposes. This work aims to study first time potential inhibitory effect of this hydroethanolic extract on α-amylase and α-glucosidase activities using in vitro methods its antidiabetic antihyperglycemic alloxan-induced diabetic mice as model experimental diabetes. Two doses were selected vivo (200 400 mg/kg) glibenclamide, well-known drug (positive control) subacute (28 days) where...

Apigenin (APG) is a very well-known flavonoid for its anti-inflammatory and anticancer properties. The purpose of this study to improve the solubility bioavailability APG using stable bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS). was incorporated in an oil phase comprising coconut fatty acid, Imwitor 988, Transcutol P, HCO30 form Bio-SNEDDS. This preparation characterized morphology, particle size, transmission electron microscopy (TEM). performance investigated terms...

Coriandrum sativum L. seeds are traditionally used to treat diabetes and its complications (inflammation formation of reactive oxygen species) around the world. The present study investigates antidiabetic, anti-inflammatory, antioxidant effects polyphenol fraction (PCS). Diabetic mice were orally administered with PCS (25 50 mg/kg b.w.) for 28 days. Oral glucose tolerance (OGTT) was also evaluated along anti-inflammatory effect, assessed by measuring paw edema development induced carrageenan...

A structural class of forty glycine transporter type 1 (GlyT1) inhibitors, was examined using molecular modeling techniques. The quantitative structure-activity relationships (QSAR) technology confirmed that human GlyT1 activity is strongly and significantly affected by constitutional, geometrical, physicochemical topological descriptors. ADME-Tox in-silico pharmacokinetics revealed L28 L30 ligands were predicted as non-toxic inhibitors with a good ADME profile the highest probability to...

Bitter gourd (Momordica charantia) has attracted the focus of researchers owing to its excellent anti-diabetic action. The beneficial effect Momordica charantia on heart been reported by in vitro and vivo studies. However developmental toxicity or potential risk M. fetus development is largely unknown. Hence this study was designed find out using zebrafish (Danio rerio) embryos.The crude extracts were prepared from fruit seeds charantia. Zebrafish embryos exposed serial dilution each...

Sphingosine kinase 1 (SphK1) has recently gained attention as a potential drug target for its association with cancer and other inflammatory diseases. Here, we have investigated the binding affinity of dietary phytochemicals viz., ursolic acid, capsaicin, DL-α tocopherol acetate, quercetin, vanillin, citral, limonin simvastatin SphK1. Docking studies revealed that all these compounds bind to SphK1 varying affinities. Fluorescence isothermal titration calorimetric measurements suggested...

Natural-based drugs are believed to be safe, effective and economical. Based on the medicinal importance of genus Eryngium unexplored nature caeruleum , we have evaluated its antidiabetic antioxidant potentials. Both in-vitro in-vivo assays been carried out for assays. The activity was determined by using different free radicals [i.e., 1,1-diphenyl,2-picrylhydrazyl (DPPH), 2,2-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS), hydrogen peroxide (H 2 O )]. Moreover, phytoconstituents...

The biological activities of propolis samples are the result many bioactive compounds present in propolis. aim study was to determine various chemical some selected collected from Palestine and Morocco by High-Performance Liquid Chromatography–Photodiode Array Detection (HPLC-PDA) method, as well antioxidant antibacterial this bee product. analysis HPLC-PDA shows cinnamic acid content Palestinian sample is higher compared that Moroccan results activity demonstrated an important free radical...

In this study, ultrasound-assisted extraction conditions were optimized to maximize the yields of sennoside A, B, aloe-emodin, emodin, and chrysophanol from S. alexandrina (aerial parts). The three UAE factors, temperature (S1), time (S2), liquid solid ratio (S3), using response surface methodology (RSM). A Box-Behnken design was used for experimental phytoconstituent analysis performed high-performance chromatography-UV. optimal found be a 64.2 °C temperature, 52.1 min time, 25.2 mL/g...

In North Africa, Tetranychus urticae Koch, 1836 represents one of the most destructive generalists among mite herbivores. Unfortunately, it is a source important annual casualties in crop production. It phytophagous that can feed on hundreds host plants and produces significant damage. The control T. Africa has been principally based acaricide sprays. However, new alternative methods have shown effective results, such as artificial ultraviolet-B, natural enemies, introduction genetic...

Breast cancer is a disease characterized by the uncontrolled proliferation of malignant cells in breast tissue, and oxidative stress activated an accumulation reactive oxygen species (ROS) associated with its development progression. Essential oils from medicinal plants, known for their antioxidant therapeutic properties, are being explored as alternatives. Ptychotis verticillata, also Nûnkha, plant native to Morocco, belonging Apiaceae family, used generations traditional medicine. This...

Resistance to isoniazid (INH) is common and increases the possibility of acquiring multidrug-resistant tuberculosis. For this study, isoniazid-loaded nanostructured lipid carriers (INH-NLCs) were developed effectively functionalized with mannose (Man) enhance residence time drug within lungs via specific delivery increase therapeutic efficacy formulation. The mannose-functionalized carrier (Man-INH-NLC) formulation was evaluated respect various parameters, namely, encapsulation efficiency...

Introduction Finding natural sources of bioactive compounds is turning into a cutting- edge task for the scientific community and industry alike. Abies marocana , Moroccan fir, holds great importance due to its ecological, economic, social, cultural significance. Material Methods The current study aimed evaluate needles in terms nutritional anti-nutrient content, components, antioxidant capacity. AOAC technique was used determine composition needles. Mineral content analyzed by inductively...

Microtubule affinity regulating kinase 4 (MARK4) plays essential role in the tau-assisted regulation of microtubule dynamics. Over expression MARK4 causes early phosphorylation Ser262 tau protein which is for binding. Hyperphosphorylation formation paired helical fragments and neurofibrillary tangles, hallmarks Alzheimer's disease. Targeting modulation activity an effective strategy therapeutic intervention other associated neurodegenerative diseases. Having pyrazolopyrimidine derivatives...

Commiphora myrrh resin (Myrrh) has been used in traditional Arabic medicine to treat various inflammatory diseases. Two furano-sesquiterpenoids, 2-methoxyfuranodiene (CM1) and 2-acetoxyfuranodiene (CM2), were isolated from the chloroform fraction of ethanolic extract resin. The cytotoxicity compounds was evaluated using human liver carcinoma, breast cancer cells (HepG2 MCF-7, respectively) normal umbilical vein endothelial (HUVECs) cell lines. development toxicity anti-angiogenic activity...

The development of antibiotic resistant in K. pneumoniae is an emerging thread worldwide due to the poor antimicrobial drugs. To overcome this issue, researchers are focused on plant material and their essential oils fight against multi drug bacteria. In context, current study was concentrated medicinal guva leaves combat bacterial infections. were successfully screened confirmed by HRLC-MS analysis. anti-bacterial ability compounds loaded into chitosan nanoparticles proved FT-IR addition,...

Anchusa italica Retz has been used for a long time in phytotherapy. The aim of the present study was to determine antioxidant and antibacterial activities extracts from leaves roots Retz. We first determined content phenolic compounds flavonoids using Folin-Ciocalteu reagents aluminum chloride (AlCl3). activity three methods: reducing power (FRAP), 2.2-diphenyl-1-picrylhydrazyl (DPPH), total capacity (TAC). antimicrobial investigated against four strains Escherichia coli, two Klebsiella...

Background/Objectives: Hyperlipidemia is a serious risk factor for cardiovascular diseases and liver steatosis. In this work, we explored the effect of an herbal formula (CBF) containing immature Ceratonia siliqua pods Ocimum basilicum extracts on lipid metabolism disorders lipoprotein-rich plasma (LRP) oxidation in mice. Methods: The phenolic composition was determined using HPLC-DAD analysis. antioxidant activity studied various vitro methods. Acute toxicity evaluated Importantly, CBF...

Introduction Morocco is renowned for its rich plant biodiversity, although many plants are underutilized. Consequently, the present study was conducted to assess nutritional composition, bioactive constituents, antioxidant properties, and acute oral toxicity of Abies marocana's woody biomass. Methods The value twigs cones determined using AOAC method, while mineral components were examined through ICP-OES. To search phytochemicals in methanolic extracts, a number established techniques...

Introduction New alternate food and pharma sources, halophyte plants have long been displaying exceptional nutritional functional qualities. Methods Present investigations were carried out to explore three important herbs; Anabasis articulata , Lycium shawii Zilla spinosa ,harvested from deserts, for phytochemical composition potential application. Results discussion Plant leaves, converted into powders showed significant amounts of ash, fiber, minerals as contents (%) ash fiber in 6.39...

Mentha pulegium L., (MP) of the Lamiaceae family, endemic to Morocco, is a medicinal plant used in classical medicine. The aim present study enhance value this species by investigating chemical composition its essential oil (EO), antioxidant activity, toxicity, molecular docking and antimicrobial properties. In vitro measurement activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) reduction assay 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid; ABTS) demonstrated plant’s best...

Introduction Milk thistle ( Silybum marianum L.) is a wild plant commonly employed in traditional medicine, particularly for its recognized applications treating liver diseases. However, there are limited data available on the phytochemical analysis and biological activity of different parts milk cultivated Morocco. Material methods This study aims to examine compare composition, antioxidant antibacterial seeds, leaves stems thistle. The has been carried out using 2,2-diphenyl-1-...