Epilepsy is one of the most common and severe brain disorders in world, characterized by recurrent spontaneous seizures due to an imbalance between cerebral excitability inhibition. Oxidative stress a biochemical state which reactive oxygen species are generated associated with various diseases including epilepsy. Pycnogenol, polyphenol obtained from pine tree has antioxidant & anti-inflammatory activity. So, aim study was evaluate effect Pycnogenol on pentylenetetrazole (PTZ)-induced...

Totipotency and Proof of the Concept: A Historical Perspective: A.D. Krikorian Isolation Culture Plant Protoplasts: Perspectives Current Status: Michael R. Davey et al. Consequences Cellular Nudity: Attila Feh r Oppurtunities K. Peter Pauls Coated Vesicles Exposed: Ultrastructural Biochemical Studies Cultured Cells L.C. Fowke Discovery Anther Technique Producing Pollen Haploids: S.C. Maheshwari Plants from Haploid Cells: K.J. Kasha Skoog Miller Legacy: 45 Years Manipulating Growth: Susan J....

In the present study, Donepezil (DPL) loaded solid lipid nanoparticles (SLNs) were formulated for brain targeting through nasal route. SLNs prepared by solvent emulsification diffusion technique using Glyceryl behenate as and blend of tween 80 poloxamer 188 (1:1) surfactant. evaluated particle size, zeta potential, drug entrapment efficiency, vitro release, stability in vivo studies. For optimized formulation, release was found to be 96.72 ± 5.89% 24 h Higuchi model fitted with highest value...

Objective: The aim of present research work was to develop a herbal fast disintegrating tablet containing Fagonia schweinfurthii Hadidi dried extract and determining its antihistaminic activity using guinea pig ileum. Method: tablets were formulated by wet granulation technique three different superdisintegrants (croscarmillose, crospovidone sodium starch glycolate) at levels. evaluated for various physical properties like hardness, friability weight variation etc. mechanical disintegration...

Pitavastatin is a competitive HMG-CoA reductase inhibitor for lowering of cholesterol level and low density lipoprotein cholesterol. This study was designed to evaluate the effect pitavastatin in neuropathic pain induced by partial sciatic nerve ligation along with neuronal changes Wister rats.Pitavastatin started three days prior surgery continued 14 The determined thermal hyperalgesia cold allodynia. biochemical were estimated at end study. levels cytokines measured using an ELISA test....

The current research work focuses mainly on evolving a delivery system for ginseng extract (GE), which in turn will ameliorate the neuroprotective potential through enhancing Ginsenoside Rb1(GRb1) bioavailability (BA). Phytosome complexes (F1, F2, and F3) were prepared by reacting GE with phospholipids disparate ratios. F3 was chosen preparing phytosomes powder (PP) phytosomes-loaded microspheres (PMs). Extract (EMs) addition of directly into same polymer mixture. gave enhanced entrapment...

Vernonia cinerea, an indigenous medicinal plant in Agasthiyar Hills, exhibits potent anticancer properties and cytotoxic effects. Research has revealed its ability to prevent the proliferation of cancer cells through several mechanisms, including induction apoptosis cell cycle arrest. Bioactive compounds from cinerea have shown inhibitory effects on key pathways involved development many cancers. Furthermore, plant's cytotoxicity against shows potential as a therapeutic agent. Studies...

In this study the T. undulata bark was tested for its hepatoprotection against paracetamol (PCM) induced hepatic damage and Carbon tetra chloride (CCl4) hepatotoxicity. The Invitro performed on HepG2 cell line .The Levels of serum marker enzymes i.e. AST, ALT (aminotransferases), ALP (alkaline phosphatase), GSH (reduced glutathione) MDA (Malondialdehyde) in 70% Ethanol treated rats were monitored, respectively. extract gave promising results as studied detail. Present showed that 70 %...

Liver is the principle organ for metabolism of various drugs, endotoxins. Hepatotoxicity one reversible conditions. Drugs are an vital cause liver injury. Drug-induced injury to can mimic any form acute or chronic disease. The action cytochrome P450 induce liver, through which drug will break down into electrophiles free radicals. These spontaneous metabolites covalently bind protein and unsaturated fatty acids lipid peroxidation, respectively. clinical presentation damage may be either...

Objectives: The aim of the present study was to determine antimicrobial property solvent extracts flowers and aerial parts S. indicus. Methods: Sphaeranthus indicus were extracted with n-hexane, benzene, chloroform, ethyl acetate acetone respectively. analyzed for effect by disc diffusion method at concentrations 5, 2.5 1.25 mg/disc. Minimum Inhibitory Concentration (MIC) tested using broth micro dilution ranging from 5 0.039 mg/ml. Results: There a significant antibacterial antifungal...

Throughout human history, plants have been employed as medicine in traditional health care systems and are seen a source of long, healthy life. Various plant components, including the roots, leaves, stem, bark, flowers, seeds, utilised to treat variety diseases. India has wide medicinal plants. Out many commonly used medical plants, Butea monosperma is possible widely appreciated for its ability elephantiasis night blindness other vision problems. Bark spicy, acrid, bitter food laxative. Its...

Background: Manilkara hexendra (Bignoniaceae) is tree species, privately known as Rohida, found in Thar Desert districts of northwest and western India. The bark acquired from the stem utilized a solution for syphilis, urinary issues, amplification spleen, gonorrhea, leucoderma, liver infections. point this work to consider hepatoprotective impact unrefined Methanolic removal portions Manikara hexendra. methanolic extricate got was assessed via cell line study HepG2 followed movement rodents...