A5004160656- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Diet and metabolism studies
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Esophageal and GI Pathology
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Pregnancy and preeclampsia studies
- Health, Environment, Cognitive Aging
- Alcoholism and Thiamine Deficiency
- Iron Metabolism and Disorders
- Fluoride Effects and Removal
- Dementia and Cognitive Impairment Research
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Blood Pressure and Hypertension Studies
- Vitamin C and Antioxidants Research
- Parathyroid Disorders and Treatments
- Delphi Technique in Research
- Gestational Diabetes Research and Management
- Celiac Disease Research and Management
- Obesity, Physical Activity, Diet
- Gastroesophageal reflux and treatments
University of Ulster
2015-2024
Food for Health Ireland
2014-2024
Portsmouth Hospitals NHS Trust
2022
Manchester Metropolitan University
2018
Trinity College Dublin
2001-2015
University College Cork
2015
University College Dublin
2005-2015
DSM (Switzerland)
2013
Trafford General Hospital
2012
Northern Health and Social Care Trust
2011
Inadequate vitamin D status is common within elderly populations and may be implicated in the etiology of autoimmune disease inflammation. Few studies have investigated relationship between age-related immune dysfunction humans.The aim this study was to investigate association markers inflammation a large sample older adults.An observational investigation 957 Irish adults (>60 years age) recruited Northern Ireland (55°N latitude) as part Trinity Ulster Department Agriculture aging cohort...
Elevated plasma homocysteine, an independent risk factor for cardiovascular disease (CVD) can be lowered by administration of pharmacological doses folic acid. The effect lower in apparently normal subjects is currently unknown but highly relevant to the question food fortification. Healthy male volunteers (n = 30) participated a chronic intervention study (26 weeks). Folic acid supplements were administered daily at increasing from 100 micrograms (6 weeks), 200 400 (14 Fasting blood samples...
Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk coronary heart disease by 11% to 16% and stroke 19% 24%. Individuals homozygous for methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism have reduced MTHFR enzyme activity resulting from inappropriate loss riboflavin cofactor, but it is unknown whether their typically high levels are responsive improved status.From register 680 healthy adults 18 65 years age known genotype, we identified 35...
Abstract Background Periconceptional folic acid prevents neural tube defects (NTDs), but it is uncertain whether there are benefits for offspring neurodevelopment arising from continued maternal supplementation beyond the first trimester. We investigated effect of during trimesters 2 and 3 pregnancy on cognitive performance in child. Methods followed up children mothers who had participated a randomized controlled trial 2006/2007 Folic Acid Supplementation Second Third Trimesters (FASSTT)...
The purpose was to examine the effect of intervention with riboflavin (a cofactor for MTHFR) on blood pressure in patients homozygous (TT genotype) common 677C-->T polymorphism MTHFR.We investigated 197 premature cardiovascular disease patients, prescreened MTHFR polymorphism, from an original cohort 404 select those TT genotype (n = 60) and a similar number heterozygous (CT; n 85) or wild-type (CC; 75) genotypes. Of these, 181 completed which participants were randomized within each group...
Intervention with riboflavin was recently shown to produce genotype-specific lowering of blood pressure (BP) in patients premature cardiovascular disease homozygous for the 677C→T polymorphism (TT genotype) gene encoding enzyme methylenetetrahydrofolate reductase (MTHFR). Whether this effect is confined high-risk unknown. The aim randomized trial, therefore, investigate responsiveness BP supplementation hypertensive individuals TT genotype but without overt disease. From an available sample...
Advancing age can be associated with an increase in cognitive dysfunction, a spectrum of disability that ranges severity from mild impairment to dementia. Folate and the other B-vitamins involved one-carbon metabolism are cognition ageing but evidence is not entirely clear. The hypothesis addressed this study was lower dietary intake or biomarker status folate and/or metabolically related would greater than expected rate decline over 4-year follow-up period healthy older adults. Participants...
Breakfast consumption is associated with higher overall dietary adequacy; however, there a lack of quantitative guidelines for optimal nutrient intakes at breakfast in the UK. This study aimed to investigate and food group examine their relationship Diet Quality (DQ). Data from most recent National Nutrition Survey (NDNS, 2008⁻2014) were accessed provide representative sample (n = 8174) UK population, aged 5⁻96 years, mean age 33 years. Food intake was measured by 4-day estimated diary DQ...
Abstract Context Emerging evidence suggests that deficiencies of folate-related B vitamins can arise with metformin treatment and are independently linked cognitive dysfunction, a comorbidity diabetes. Objective To determine the impact hyperglycemia use on relevant vitamin biomarkers outcomes in older adults. Setting Participants Community-dwelling adults (74.1 ± 8.3 years, n = 4160) without dementia, recruited to Trinity, Ulster Department Agriculture cohort study 2008 2012, were classified...