A5036659191- Biochemical Analysis and Sensing Techniques
- Folate and B Vitamins Research
- Advanced Chemical Sensor Technologies
- Consumer Attitudes and Food Labeling
- Olfactory and Sensory Function Studies
- Esophageal and GI Pathology
- Nutritional Studies and Diet
- Vitamin C and Antioxidants Research
- Inflammation biomarkers and pathways
- Alzheimer's disease research and treatments
- Machine Learning in Healthcare
- Birth, Development, and Health
- Artificial Intelligence in Healthcare
- Hydrogen's biological and therapeutic effects
- Mental Health Treatment and Access
- COVID-19 epidemiological studies
- Dementia and Cognitive Impairment Research
- Mental Health Research Topics
- SARS-CoV-2 and COVID-19 Research
- Fluoride Effects and Removal
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child and Adolescent Psychosocial and Emotional Development
- Respiratory Support and Mechanisms
- Metabolism and Genetic Disorders
- Vaccine Coverage and Hesitancy
University of Ulster
2004-2023
Altnagelvin Area Hospital
2018
Food for Health Ireland
2006-2017
Trinity College Dublin
2005
University College Dublin
2005
Belfast City Hospital
2000
Queen's University Belfast
1999
Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk coronary heart disease by 11% to 16% and stroke 19% 24%. Individuals homozygous for methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism have reduced MTHFR enzyme activity resulting from inappropriate loss riboflavin cofactor, but it is unknown whether their typically high levels are responsive improved status.From register 680 healthy adults 18 65 years age known genotype, we identified 35...
Anxiety and depression are common, debilitating costly. These disorders influenced by multiple risk factors, from genes to psychological vulnerabilities environmental stressors, but research is hampered a lack of sufficiently large comprehensive studies. We recruiting 40,000 individuals with lifetime or anxiety broad assessment risks facilitate future research. The Genetic Links Depression (GLAD) Study (www.gladstudy.org.uk) recruits into the NIHR Mental Health BioResource. Participants...
Abstract There is currently a lack of an efficient, objective and systemic approach towards the classification Alzheimer’s disease (AD), due to its complex etiology pathogenesis. As AD inherently dynamic, it also not clear how relationships among indicators vary over time. To address these issues, we propose hybrid computational for evaluate on heterogeneous longitudinal AIBL dataset. Specifically, using clinical dementia rating as index severity, most important (mini-mental state...
Patients with cystic fibrosis experience chronic systemic oxidative stress. This is coupled inflammation of the lung involving bronchial polymorphonuclear neutrophil accumulation and activation. We hypothesised that, during periods acute respiratory exacerbation, free radical activity consequent damage would be most marked that intensive treatment infection result in improvement towards values found stable periods.Plasma red blood cells were collected from 12 healthy normal volunteers...
Although the use of low-calorie sweeteners (LCSs) is widespread, methods assessing consumption within free-living populations have inherent limitations. Five commonly consumed LCSs, namely, acesulfame-K, saccharin, sucralose, cyclamate, and steviol glycosides, are excreted via urine, therefore a urinary biomarker approach may provide more objective LCS intake data. A LC-ESI-MS/MS method simultaneously determining excretory metabolite glucuronide, in human urine was developed validated....
Patients with cystic fibrosis (CF) experience a combination of chronic systemic oxidative stress, generation free radicals in the lungs due to hyperimmune response and diminished ability scavenge secondary malabsorption increased consumption. The authors asked question, "Does breath isoprene content reflect stress?" study involved 12 CF patients matched healthy controls. were sampled during acute respiratory exacerbation (increased symptoms, reduction forced expiratory volume (FEV1) >10%,...
With the increased uptake of COVID-19 vaccination in 2021, universities resumed face-to-face classes and clinical placements. However, even with incentives, some individuals chose not to receive a due personal beliefs other reasons. Understanding motivations for or vaccine hesitancy is important help develop future public health strategies. Therefore, cross-sectional online survey was carried out among students staff UK university assess level explore their views on acceptability incentives...
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Response to Letter Regarding Article, "Riboflavin Lowers Homocysteine in Individuals Homozygous for the MTHFR 677C3 T Polymorphism"We thank Powers et al their positive comments on our article. 1Their criticism is that sample not representative of United Kingdom or European populations, and interpretation results relation food policy therefore inappropriate.The statement statistical inference compromised misleading because it very clear article being made about general population, but rather...