Henry C. Rogers
A5068588728- Mental Health Research Topics
- Long-Term Effects of COVID-19
- Eating Disorders and Behaviors
- COVID-19 and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Intensive Care Unit Cognitive Disorders
- Epigenetics and DNA Methylation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health disparities and outcomes
- Bipolar Disorder and Treatment
- Posttraumatic Stress Disorder Research
- Mental Health Treatment and Access
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Obesity and Health Practices
- Tryptophan and brain disorders
- Renal and related cancers
- Child Nutrition and Feeding Issues
- Analytical Methods in Pharmaceuticals
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Cancer Treatment and Pharmacology
- Suicide and Self-Harm Studies
- Lymphoma Diagnosis and Treatment
- Soil and Environmental Studies
King's College London
2010-2025
South London and Maudsley NHS Foundation Trust
2022-2025
National Institute for Health Research
2019-2023
Maudsley Hospital
2021-2023
Psychiatry Research Trust
2023
NIHR Maudsley Dementia Biomedical Research Unit
2022-2023
Centre for Mental Health
2021-2022
NIHR Maudsley Biomedical Research Centre
2022
University of Ulster
2019
Guy's Hospital
1985
Anxiety and depression are common, debilitating costly. These disorders influenced by multiple risk factors, from genes to psychological vulnerabilities environmental stressors, but research is hampered a lack of sufficiently large comprehensive studies. We recruiting 40,000 individuals with lifetime or anxiety broad assessment risks facilitate future research. The Genetic Links Depression (GLAD) Study (www.gladstudy.org.uk) recruits into the NIHR Mental Health BioResource. Participants...
Abstract Background The impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health is still being unravelled. It important to identify which individuals are at greatest risk worsening symptoms. This study aimed examine changes in depression, anxiety and post-traumatic stress disorder (PTSD) symptoms using prospective retrospective symptom change assessments, find effect key factors. Method Online questionnaires were administered 34 465 (aged 16 years or above) April/May 2020...
<title>Abstract</title> The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention treatment strategies. We report the one-year cognitive, serum biomarker, neuroimaging findings from a prospective, national longitudinal study cognition in 351 COVID-19 patients who had required hospitalisation, compared 2,927 normative matched controls. Cognitive were global associated with elevated brain injury...
Understanding and improving outcomes for people with anxiety or depression often requires large sample sizes. To increase participation reduce costs, such research is typically unable to utilise "gold-standard" methods ascertain diagnoses, instead relying on remote, self-report measures. Assess the comparability of remote diagnostic disorders commonly used in research. Participants from UK-based GLAD COPING NBR cohorts (N = 58,400) completed an online questionnaire between 2018 2020....
Abstract Depression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence genetic relationship mixed. Assessing depression symptom-specific associations may better clarify this relationship. To address this, we conducted genome-wide meta-analysis (a association study, GWAS) nine symptom items, plus their sum score, on Patient Health Questionnaire (PHQ-9) (GWAS-equivalent N : 224,535–308,421) using data from UK Biobank, GLAD study and PROTECT, identifying 37...
Abstract The Mood Disorder Questionnaire (MDQ) is a common screening tool for bipolar disorder that assesses manic symptoms. Its utility genetic studies of mania or traits has not been fully examined. We psychometrically compared the MDQ to self‐reported in participants from United Kingdom National Institute Health and Care Research Mental BioResource. conducted genome‐wide association symptom quantitative subgroups, derived items ( N = 11,568–19,859). calculated correlations with other...
Abstract Objective The disruption caused by the COVID‐19 pandemic has been associated with poor mental health, including increases in eating disorders and self‐harm symptoms. We investigated risk protective factors for new onset of these symptoms during pandemic. Method Data were from Psychiatry Neurological Genetics study Repeated Assessment Mental health Pandemics Study ( n = 36,715). Exposures socio‐demographic characteristics, lifetime psychiatric disorder, COVID‐related variables,...
Background Generalized anxiety and depression are extremely prevalent debilitating. There is evidence for age sex variability in symptoms of depression, but despite comorbidity it unclear whether this extends to symptomatology. Studies using questionnaire sum scores typically fail address phenotypic complexity. Method We conducted exploratory confirmatory factor analyses on Anxiety Disorder (GAD-7) Patient Health Questionnaire (PHQ-9) items identify latent factors participants from the...
The Genetic Links to Anxiety and Depression (GLAD) Study is a large cohort of individuals with lifetime anxiety and/or depression, designed facilitate re-contact participants for mental health research. At the start pandemic, from three cohorts, including GLAD Study, were invited join COVID-19 Psychiatry Neurological Genetics (COPING) study monitor neurological health. However, previous research suggests that participation in longitudinal studies follows systematic, rather than random,...
Reported trauma is associated with differences in the course and outcomes of depression anxiety. However, no research has explored association between reported patterns clinically relevant symptoms both
Abstract Objectives People with bipolar disorder who also report binge eating have increased psychopathology and greater impairment than those without eating. Whether this co‐occurrence is related to as a symptom or presents differently across full‐syndrome disorders unclear. Methods We first compared networks of 13 lifetime mania symptoms in 34,226 participants from the United Kingdom's National Institute for Health Care Research BioResource ( n = 12,104) 22,122) Second, subsample eating,...
Abstract Background Anxiety and depression are common, debilitating costly. These disorders influenced by multiple risk factors, from genes to psychological vulnerabilities environmental stressors but research is hampered a lack of sufficiently large comprehensive studies. We recruiting 40,000 individuals with lifetime or anxiety, broad assessment risks facilitate future research. Methods The Genetic Links Depression (GLAD) Study ( www.gladstudy.org.uk ) recruits anxiety into the NIHR Mental...
Oxprenolol was administered in single doses by mouth to healthy volunteers either a polymer‐matrix slow‐release formulation (Slow Trasicor) or osmotic drug‐delivery systems (oxprenolol Oros). Plasma oxprenolol concentrations and heart rates after exercise were measured. of the drug maximal at 3 h but negligible 24 administration Slow Trasicor. Following ingestion Oros measurable maintained throughout h. Significant reduction exercise‐induced tachycardia persisted for Oros. With Trasicor rate...
Abstract Objective The United Kingdom Eating Disorders Genetics Initiative (EDGI UK), part of the National Institute for Health and Care Research (NIHR) Mental BioResource, aims to deepen our understanding environmental genetic etiology eating disorders. EDGI UK launched in February 2020 is partnered with disorders charity, Beat. Multiple branches exist worldwide. This article serves dual function providing an in‐depth description study protocol describing initial sample including...
Abstract Background: The Genetic Links to Anxiety and Depression (GLAD) Study is a large cohort of individuals with lifetime anxiety and/or depression, designed facilitate re-contact participants for mental health research. At the start pandemic, from three cohorts, including GLAD Study, were invited join COVID-19 Psychiatry Neurological Genetics (COPING) study monitor neurological health. However, previous research suggests that participation in longitudinal studies follows systematic,...
Objective: The disruption caused by the COVID-19 pandemic has been associated with poor mental health, including increases in eating disorder and self-harm symptoms. We investigated risk protective factors for new onset of these symptoms during pandemic. Method: Data were from Psychiatry Neurological Genetics study Repeated Assessment Mental health Pandemics Study (n = 45,058). Exposures socio-demographic characteristics, lifetime psychiatric disorder, COVID-related variables, SARS-CoV-2...
Progress towards stratified care for anxiety and depression will require the identification of new predictors. We collected data on retrospectively self-reported therapeutic outcomes in adults who received psychological therapy UK past ten years. aimed to replicate factors associated with traditional treatment outcome measures from literature.
Abstract Depression is a risk factor for Alzheimer’s disease (AD), but evidence their genetic relationship mixed. Assessing depression symptom specific associations may better clarify this relationship. Using data from the UK Biobank, GLAD Study and PROTECT, we performed largest genome-wide meta-analyses (GWAS) of nine items, plus sum score, on Patient Health Questionnaire (PHQ-9) (GWAS equivalent N: 224,535—308,421). We assessed global/local correlations statistical colocalisation between...