A5013944654- Dementia and Cognitive Impairment Research
- Aging and Gerontology Research
- Health disparities and outcomes
- Psychological Well-being and Life Satisfaction
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Cognitive Abilities and Testing
- Functional Brain Connectivity Studies
- Blood Pressure and Hypertension Studies
- Retirement, Disability, and Employment
- Cognitive Functions and Memory
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Healthcare Systems and Public Health
- Nutritional Studies and Diet
- Frailty in Older Adults
- Psychological and Temporal Perspectives Research
- Technology Use by Older Adults
- Sleep and Wakefulness Research
- Optimism, Hope, and Well-being
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical Analysis and Sensing Techniques
- Behavioral Health and Interventions
University of Exeter
2018-2025
At Bristol
2021-2024
Northumbria University
2020-2021
University of Tasmania
2020
Imperial College London
2020
Colorado State University
2020
University of Cologne
2020
Swinburne University of Technology
2020
Cambridge Cognition (United Kingdom)
2017-2018
United BioSource Corporation (United Kingdom)
2010-2012
Traumatic brain injury (TBI) causes cognitive impairment but it remains contested regarding which domains are most affected. Further, moderate-severe TBI is known to be deleterious, studies of mild (mTBI) show a greater mix negative and positive findings. This study examines the longer-term effects severity number mTBIs in later life. We examined subset (n = 15,764) PROTECT study, cohort assessing risk factors for decline (ages between 50 90 years). Participants completed assessments...
In this large population study, we set out to examine the profile of mild behavioral impairment (MBI) by using Mild Behavioral Impairment Checklist (MBI-C) and explore its factor structure when employed as a self-reported informant-rated tool.This was population-based cohort study.Participants were recruited from Platform for Research Online Investigate Genetics Cognition in Aging study (https://www.protect-exeter.org.uk).A total 5,742 participant-informant dyads participated study.Both...
We recently showed that a short-term high-fat diet blunted exercise performance in rats, accompanied by increased uncoupling protein levels and greater respiratory uncoupling. In this study, we investigated the effects of similar on physical cognitive humans. Twenty sedentary men were assessed when consuming standardized, nutritionally balanced (control) after7dof comprising 74% kcal from fat. Efficiency was measured during standardized task, cognition using computerized assessment battery....
Social isolation is likely to be recommended for older adults due COVID-19, with ongoing reduced clinical contact suggested this population. This has increased the need remote memory clinics, we therefore review literature, current practices and guidelines on organizing such focusing assessment of cognition, function other relevant measurements, proposing a novel pathway based three levels complexity: simple telephone or video-based interviews testing using available tests (Level 1),...
Abstract Introduction Late‐life onset psychosis is associated with faster progression to dementia in cognitively normal people, but little known about its relationship cognitive impairment advance of dementia. Methods Clinical and genetic data from 2750 people ≥50 years age without were analyzed. Incident was operationalized using the Informant Questionnaire on Cognitive Decline Elderly (IQCODE) rated Mild Behavioral Impairment Checklist (henceforth MBI‐psychosis). The whole sample analyzed...
<h3>Objectives</h3> Attentional augmentation and enhanced motor function are potential mechanisms by which stimulation of the region pedunculopontine nucleus (PPN) may improve gait in parkinsonism. Here, authors assess impact this on attentional aspects reaction task performance patients with <h3>Methods</h3> Eleven implanted PPN stimulators underwent computerised assessment simple, choice digit vigilance tasks. Patients were assessed 'off medication' during at different frequencies (0 Hz, 5...
Objective The advent of long‐term remotely conducted clinical trials requires assessments which can be administered online. This paper considers the utility, reliability, sensitivity and validity an internet‐based system for measuring changes in cognitive function is being used one such trial. Methods Platform Research Online to investigate Genetics Cognition Ageing a 10‐year longitudinal entirely remote study launched November 2015. CogTrack TM System monitor important aspects using tests...
Objective Several potentially modifiable risk factors for cognitive decline and dementia have been identified, including low educational attainment, smoking, diabetes, physical inactivity, hypertension, midlife obesity, depression, perceived social isolation. Managing these in late older age may help reduce the of dementia; however, it is unclear whether also relate to performance individuals without dementia. Method Data from 14 201 non‐demented aged >50 years who enrolled online PROTECT...
Abstract Depression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence genetic relationship mixed. Assessing depression symptom-specific associations may better clarify this relationship. To address this, we conducted genome-wide meta-analysis (a association study, GWAS) nine symptom items, plus their sum score, on Patient Health Questionnaire (PHQ-9) (GWAS-equivalent N : 224,535–308,421) using data from UK Biobank, GLAD study and PROTECT, identifying 37...
There is a growing body of evidence from randomized controlled trials which indicates that consumption berries has positive effect upon the cognitive function healthy adults. It been recommended studies combining and physiological measures be undertaken in order to strengthen base for putative effects flavonoid on outcomes. This pilot study utilized randomized, double-blind placebo crossover design assess influence acute administration anthocyanin-rich blackcurrant juice, standardized at 500...
Abstract Background A questionnaire assessing awareness of positive and negative age-related changes (AARC gains losses) was developed in the US Germany. We validated short form measure (AARC-10 SF) cognitive functioning subscale from 50-item version AARC (AARC-50) UK population aged 50 over. Methods Data 9410 participants (Mean (SD) age = 65.9 (7.1)) PROTECT cohort were used to explore confirm psychometric properties measures including: validity factor structure; reliability; measurement...
Introduction Sensitive neuropsychological tests are needed to improve power for clinical trials in early Alzheimer's disease (AD). Methods To develop a composite (FLAME – Factors of Longitudinal Attention, Memory and Executive Function), we assessed, 10,714 participants over the age 50 from PROTECT with validated computerized assessments 2 years. A factorial analysis was completed identify key cognitive factors all participants, further analyses examined sensitivity change people stage 2/3...
ABSTRACT Objectives: Evidence linking subjective concerns about cognition with poorer objective cognitive performance is limited by reliance on unidimensional measures of self-perceptions aging (SPA). We used the awareness age-related change (AARC) construct to assess self-perception both positive and negative changes (AARC gains losses). tested whether AARC has greater utility in compared well-established aging. examined associations cognition, several psychological variables, engagement...
The present study compared the cognitive and mood effects of two commercially available products, Red Bull energy drink 250 mL Sugarfree mL, together with a matching placebo mL. Twenty-four healthy young volunteers took part in randomised, controlled, double-blind, three-way cross-over study. Cognitive function was assessed using an integrated set nine computerised tests attention, working episodic memory. On each day received standardised breakfast prior to completing baseline performance...
Objectives Depressive disorder is commonly associated with impaired cognitive function; however, it unclear whether the age of onset first episode depression, current depression severity, or historical severity depressive episodes are performance. Methods This study examined baseline cross‐sectional data from ongoing online PROTECT study. A total 7344 participants, 50 years older, a history and no diagnosis dementia were divided into three groups according to their episode: early‐onset,...
Abstract Cognitive differences in memory, information processing speed (IPS), and executive functions (EF), are common autistic high trait populations. Despite IPS EF being sensitive to age‐related change, little is known about the cognitive profile of older adults with traits. This study explores cross‐sectional task performance a large sample online PROTECT cohort ( n = 22,285, aged 50–80 years), grouped by vs. low Approximately 1% participants 325) endorsed traits [henceforth Autism...
The identification of modifiable lifestyle factors to preserve cognitive function in older individuals becomes increasingly importance. This study examines whether word puzzle use is related adults.Cognitive data from 19 078 cognitively healthy aged 50 93 years enrolled into the online PROTECT were evaluated for self-reported frequency performing puzzles on a six-point scale, ranging "more than once per day" "never". Nine tests covered range domains including focussed and sustained...
Background: Traumatic brain injury (TBI) is prevalent in veterans and may occur at any stages of their life (before, during, or after military service). This particular concern, as previous evidence the general population has identified TBI a strong risk factor for mild cognitive impairment (MCI), known precursor dementia.
ObjectivesTo establish the impact of a 3-minute computerized cognitive training program (START) on cognition in older adults with and without genetic risk Alzheimer's disease.DesignTwo-arm randomized controlled trial START program.Setting ParticipantsRemote online than 50 taking part from home.MethodsThe compared placebo 6544 people 50. Primary outcome was executive function measured through Trailmaking B, other secondary measures. Genetic profile ApoE4 status were determined by Illumina...
Sleep is vital for normal cognitive function in daily life, but commonly disrupted older adults. Poor sleep can be detrimental to mental and physical health, including function. This study assessed the association between self-reported short (<6 h) long (>9 duration fragmentation (3≥ nightly awakenings) function.Cross-sectional data from 8508 individuals enroled PROTECT aged 50 above formed basis of univariate linear regression analysis conducted on four outcomes assessing visuospatial...
The concept of Awareness Age-Related Changes captures people's perceptions the positive (AARC-gains) and negative (AARC-losses) age-related changes they experience in several life domains, including their health. We investigated cross-sectional associations number type physical mental health conditions with AARC-gains AARC-losses.The sample comprised 3,786 middle-aged older adults (mean age = 67.04 years; SD 6.88) participating to UK PROTECT study. used hierarchical regression models analyze...