John T. O’Brien

ORCID: 0000-0002-0837-5080
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About
Contact & Profiles
Research Areas
  • Dementia and Cognitive Impairment Research
  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Functional Brain Connectivity Studies
  • Advanced Neuroimaging Techniques and Applications
  • Neurological Disease Mechanisms and Treatments
  • Advanced MRI Techniques and Applications
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cerebrovascular and Carotid Artery Diseases
  • Neurological disorders and treatments
  • Acute Ischemic Stroke Management
  • Neurological Disorders and Treatments
  • Ginkgo biloba and Cashew Applications
  • Tryptophan and brain disorders
  • Health Systems, Economic Evaluations, Quality of Life
  • Diet and metabolism studies
  • EEG and Brain-Computer Interfaces
  • French Literature and Criticism
  • Cerebrovascular and genetic disorders
  • Cholinesterase and Neurodegenerative Diseases
  • Renaissance Literature and Culture
  • Stress Responses and Cortisol
  • Memory and Neural Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Neural dynamics and brain function

Bedford Institute of Oceanography
2025

Fisheries and Oceans Canada
2025

University of Cambridge
2016-2025

Cambridge University Hospitals NHS Foundation Trust
2013-2025

Addenbrooke's Hospital
2012-2025

Cambridgeshire and Peterborough NHS Foundation Trust
2015-2025

Dementia UK
2024

Newcastle University
2015-2024

The University of Texas at Dallas
2023-2024

University of Exeter
2023-2024

Restricted accessAbstractFirst published online December 1, 2014Vascular Cognitive ImpairmentVolume 9, Issue 4_supplhttps://doi.org/10.1111/ijs.12374_18

10.1111/ijs.12374_18 article EN International Journal of Stroke 2014-11-01

Background: Several sets of diagnostic criteria have been published for vascular dementia since the 1960s. The continuing ambiguity in definition warrants a critical reexamination. Methods: Participants at special symposium International Society Vascular Behavioral and Cognitive Disorders (VASCOG) 2009 critiqued current criteria. They drafted proposal new set criteria, later reviewed through multiple drafts by group, including additional experts members Neurocognitive Work Group fifth...

10.1097/wad.0000000000000034 article EN Alzheimer Disease & Associated Disorders 2014-03-14

Abstract Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes biomarker‐based pathologic definition of focused amyloid, tau, neuronal injury. In response this article, here we first discussed that dysfunction is an important early event in...

10.1016/j.jalz.2018.07.222 article EN Alzheimer s & Dementia 2019-01-01

Background and Purpose— “Incidental” MRI white matter (WM) lesions, comprising periventricular lesions (PVLs) deep subcortical (DSCLs), are common in the aging brain. Direct evidence of ischemia associated with incidental WM (WMLs) has been lacking, their pathogenesis is unresolved. Methods— A population-based, postmortem cohort (n=456) donated brains was examined by pathology. In a subsample whole cohort, magnetic resonance images were used to sample compare WMLs nonlesional for molecular...

10.1161/01.str.0000221308.94473.14 article EN Stroke 2006-04-21

In 2008 a task force was set up to develop revision of the European Federation Neurological Societies (EFNS) guideline for diagnosis and management Alzheimer's disease (AD) other disorders associated with dementia, published in early 2007. The aim this revised international present peer-reviewed evidence-based statement guidance practice clinical neurologists, geriatricians, psychiatrists, specialist physicians responsible care patients AD. Mild cognitive impairment non-Alzheimer dementias...

10.1111/j.1468-1331.2010.03040.x article EN European Journal of Neurology 2010-05-05

<b><i>Objective:</i></b> To determine the validity of a clinical diagnosis probable or possible dementia with Lewy bodies (DLB) made using International Consensus criteria. <b><i>Background:</i></b> Validation studies based on retrospective chart reviews autopsy-confirmed cases have suggested that diagnostic specificity for DLB is acceptable but case detection rates as low 0.22 been suggested. <b><i>Methods:</i></b> We evaluated first 50 reaching neuropathologic autopsy in cohort to which...

10.1212/wnl.54.5.1050 article EN Neurology 2000-03-14

Age-related white matter changes (ARWMC) on brain MRI have been associated with cognitive, motor, mood and urinary disturbances. These factors are known to contribute disability in elderly people, but the impact of ARWMC their progression transition is not determined. The LADIS (Leukoaraiosis Disability Elderly) study aims at assessing role as an independent predictor initially nondisabled (65–84 years). Subjects who impaired or only 1 item Instrumental Activity Daily Living (IADL) scale,...

10.1159/000081050 article EN Neuroepidemiology 2004-09-24

<h3>OBJECTIVES</h3> Alzheimer's disease and vascular dementia are associated with an increase in changes white matter on MRI. The aims were to investigate whether also occur Lewy bodies examine the relation between lesions cognitive non-cognitive features of bodies, disease, dementia. <h3>METHODS</h3> Proton density T2 weighted images obtained a 1.0 Tesla MRI scanner patients (consensus criteria; n=27, mean age=75.9 years), (NINCDS/ADRDA; n=28, age=77.4 (NINDS/AIREN; n=25, age=76.8 normal...

10.1136/jnnp.67.1.66 article EN Journal of Neurology Neurosurgery & Psychiatry 1999-07-01
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