Douglas Galasko
A5072592799- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Functional Brain Connectivity Studies
- Cholinesterase and Neurodegenerative Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Bioinformatics and Genomic Networks
- Ginkgo biloba and Cashew Applications
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Folate and B Vitamins Research
- S100 Proteins and Annexins
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Computational Drug Discovery Methods
- Nuclear Receptors and Signaling
- Neurobiology of Language and Bilingualism
- Epigenetics and DNA Methylation
- Frailty in Older Adults
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Memory and Neural Mechanisms
University of California, San Diego
2016-2025
Northwestern University
2024
Inha University
2024
VA San Diego Healthcare System
2015-2024
Indiana University – Purdue University Indianapolis
2020-2024
VIB-UAntwerp Center for Molecular Neurology
2024
University of Antwerp
2024
University of California, Los Angeles
1995-2024
University of California San Diego Medical Center
2005-2024
University of Iowa
2000-2024
Based on the recent literature and collective experience, an international consortium developed revised guidelines for diagnosis of behavioural variant frontotemporal dementia. The validation process retrospectively reviewed clinical records compared sensitivity proposed earlier criteria in a multi-site sample patients with pathologically verified lobar degeneration. According to criteria, 'possible' dementia requires three six clinically discriminating features (disinhibition,...
Mild cognitive impairment is a transitional state between the changes of normal aging and early Alzheimer's disease.
Thirty-six clinically diagnosed and pathologically confirmed Alzheimer9s disease (AD) patients included 13 with cortical subcortical Lewy bodies (LBs). The LBs appeared to constitute a distinct neuropathologic clinical subset of AD, the body variant (LBV). LBV group showed gross pallor substantia nigra, greater neuron loss in locus ceruleus, innominata, lower neocortical ChAT levels, fewer midfrontal tangles than did pure AD group, along high incidence medial temporal lobe spongiform...
A Clinical Task Force, composed of clinical leaders from Alzheimer's Disease Centers (ADC), was convened by the National Institute on Aging to develop a uniform set assessment procedures characterize individuals with mild Alzheimer disease and cognitive impairment in comparison nondemented aging. The resulting Uniform Data Set (UDS) defines common observations be collected longitudinally ADC participants accordance standard methods. UDS implemented at all ADCs September 1, 2005. obtained are...
Abstract In this clinical study, the cerebrospinal fluid (CSF) level of a Novemberel form β‐amyloid peptide (Aβ) extending to position 42 (Aβ ) was determined in patients with Alzheimer's disease (AD) as well controls. addition measurement CSF Aβ levels, total peptides, microtubule‐associated protein τ, and apolipoprotein E (ApoE) genotype were also assessed. It is interesting that levels found be significantly lower AD relative controls, whereas not. has recently been shown preferentially...
We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer's Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward Jak a
Biomarkers are urgently needed for the diagnosis and monitoring of disease progression in Parkinson’s disease. Both DJ-1 α-synuclein, two proteins critically involved pathogenesis, have been tested as biomarkers several recent studies with inconsistent results. These largely due to variation protein species detected by different antibodies, limited numbers patients some studies, or inadequate control important variables. In this study, nature α-synuclein human cerebrospinal fluid was studied...