A5101619582- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Fibroblast Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Electrocatalysts for Energy Conversion
- nanoparticles nucleation surface interactions
- Magnetism in coordination complexes
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanocluster Synthesis and Applications
- Organometallic Complex Synthesis and Catalysis
- Theoretical and Computational Physics
- Solidification and crystal growth phenomena
- Immune Cell Function and Interaction
- Craniofacial Disorders and Treatments
- Machine Learning in Materials Science
- Neutropenia and Cancer Infections
- Cleft Lip and Palate Research
- Asymmetric Synthesis and Catalysis
- Fullerene Chemistry and Applications
- Neurogenesis and neuroplasticity mechanisms
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- CAR-T cell therapy research
- Blood disorders and treatments
- Advanced Battery Materials and Technologies
University of Maryland, Baltimore
2022-2024
Massachusetts Institute of Technology
2015-2023
Stanford University
2000-2023
MIT University
2023
Moscow Institute of Thermal Technology
2023
Cornell University
2023
Fort Hays State University
2023
New York State College of Veterinary Medicine
2023
University of Pennsylvania
2022
University of Illinois Urbana-Champaign
2017-2020
Optimizing the use of expensive precious metals is critical to developing sustainable and low-cost processes for heterogeneous catalysis or electrochemistry. Here, we report a synthesis method that yields core-shell Cu-Ru, Cu-Rh, Cu-Ir nanoparticles with platinum-group segregated on surface. The particles allows maximization surface area these improves catalytic performance. Furthermore, Cu core can be selectively etched obtain nanoshells metal components, leading further increase in active...
The silver(I) species [Ag(benzim(CH2py)2)2]PF6 (1) was prepared by refluxing the ligand precursor [H(benzim(CH2py)2)2]PF6 with Ag2O and aqueous sodium hydroxide in dichloromethane. Simple transmetalation of 1 tetrahydrothiophenegold(I) chloride forms gold(I) analogue [Au(benzim(CH2py)2)2]PF6 (2). addition 2 equiv [Cu(NCCH3)4]PF6 to acetonitrile produces a blue-luminescent, trimetallic complex, [AuCu2(benzim(CH2py)2)2(NCCH3)4](PF6)3·2CH3CN (3·2CH3CN). When blue-luminescent 3·2CH3CN is exposed...
A series of Cu4X4(PPh2py)2 compounds (X = Cl (1), Br (2), I (3), PPh2py 2-(diphenylphosphino)pyridine) were prepared and characterized using X-ray crystallography, NMR, UV-vis, luminescence spectroscopy. The copper chloride bromide clusters have Cu4X4 octahedral cores while the iodide contain an unprecedented butterfly shaped core. Crystallization from appropriate solvent produced solvates 2·2CH2Cl2, 2·2CHCl3, 3·0.5CH2Cl2 where presence lattice solvate influences overall structural...
The area and volume of brain structural features, as assessed by high-resolution three-dimensional magnetic resonance imaging (MRI), are among the most heritable measures relating to human CNS. We have conducted MRI scanning all available monkeys >2 years age (n = 357) from extended multigenerational pedigree Vervet Research Colony (VRC). Using a combination automated manual segmentation we quantified several correlated but distinct phenotypes. estimated heritabilities (h(2)) for these in...
While the function of many leukocytes in transplant biology has been well defined, role eosinophils is controversial and remains poorly explored. Conflicting data exist regarding eosinophils' alloimmunity. Due to their prevalence lung, defined other pulmonary pathologies such as asthma, we set out explore long-term maintenance lung allograft. We noted that depletion results generation donor-specific antibodies. Eosinophil increased memory B cell, plasma antibody-secreting cell...
The successful preparation and isolation of the mixed-metal endohedral fullerene, LaSc2N@Ih-C80, its structural characterization by single-crystal X-ray diffraction are reported. Results from chemically adjusting plasma temperature, energy, reactivity (CAPTEAR) experiments indicate that a 10 wt % addition Cu(NO3)2·2.5H2O to mixture La2O3 Sc2O3 decreases amount C60 C70 found in soot extracts an order magnitude. By combining stoichiometric 2-fold excess La Sc atoms reactor, extract containing...
The trigonally coordinated [AuCu(PPh(2)py)(3)](BF(4))(2) (1) crystallizes in two polymorphs and a pseudopolymorph, each of which contains cation with short Au(I)-Cu(I) separations ∼2.7 Å. Under UV illumination, these crystals luminesce different colors ranging from blue to yellow. structures cations are nearly superimposable, the primary difference resides relative placement anions solvate molecules. As confirmed by time-dependent density functional theory calculations, it is interactions...
The mammalian hippocampus shows marked decline in function with aging across many species, including humans and laboratory rodent models. This frequently manifests memory impairments that occur even the absence of dementia pathology. In humans, a number factors correlate preserved hippocampal aging, such as exercise, cognitive stimulation social ties. While interventional studies animal models clearly indicate exercise lead to preservation, there is relatively little research on whether ties...
Graphite-conjugated catalysts (GCCs) are a promising class of materials that combine many the advantages heterogeneous and homogeneous catalysts. In particular, GCCs containing an aryl-pyridinium active site appear to be effective nonmetal for oxygen reduction reaction (ORR). this study, we analyzed both structural electronic properties dataset molecules nitrogen atoms embedded in aromatic order understand which enable particular bind O2, is necessary step initiation ORR. We found carbon...
A unique type of craniofacial dysostosis, Crouzon syndrome with acanthosis nigricans (CAN), has been attributed to a specific substitution (Ala391Glu) in the fibroblast growth factor receptor 3 (FGFR3) gene. At birth, individuals this disorder have craniosynostosis, ocular proptosis, midface hypoplasia, choanal atresia, hydrocephalus, and they experience onset during childhood. We report three cases compare clinical characteristics our previously reported disorder. Since Ala391Glu FGFR3 is...
A series of Au(I)–Cu(I) N-heterocyclic carbene (NHC) halide complexes [AuCu2(im(CH2py)2)2X]2+ where X = Cl (1), Br (2), I (3) was prepared by refluxing [AuCu2(im(CH2py)2)2(NCCH3)4]3+ with the appropriate in acetonitrile. The compounds were characterized NMR, absorption, and fluorescence spectroscopy. They feature similar solution behavior solid-state photoemissions. structures a rhomboidal [AuCu2X]2+ core which is influenced type halide. Compared to other NHC complexes, 1–3 comprise new...
Congenital muscular dystrophy type 1A (MDC1A) is caused by recessive variants in laminin α2 (LAMA2). Patients have been found to white matter signal abnormalities on magnetic resonance imaging (MRI) but rarely structural brain abnormalities. We describe the autopsy neuropathology a 17-year-old with MRI. Dystrophic pathology was observed skeletal muscle, and sural nerve manifested mild degree of segmental demyelination remyelination. A diffuse, bilateral cobblestone appearance, numerous...
Abstract Adult neural stem and progenitor cells (NSPCs) reside in the dentate gyrus (DG) of hippocampus throughout lifespan most mammalian species. In addition to generating new neurons, NSPCs may alter their niche via secretion growth factors cytokines. We recently showed that adult DG secrete vascular endothelial factor (VEGF), which is critical for maintaining neurogenesis. Here, we asked whether NSPC-derived VEGF alters hippocampal function independent found loss acutely impaired memory,...
Geographic variation in body size is common within many animal species. The causes of this pattern, however, remain largely unexplored most vertebrate groups. Bats are widely distributed globally owing to their ability powered flight. Most bat species encounter a variety climatic conditions across distribution range, making them an ideal taxon for the study ecogeographic patterns size. Here, we used adult least horseshoe bats, Rhinolophus pusillus, test whether geographic was determined by...
Polyhydroxylated piperidines are a functionally rich class of biologically active molecules that have broad therapeutic potential.
// Chunmei Zhao 1 , Benjamin J. Thompson * Kelly Chen Feng Gao Barbara Blouw Mathieu Marella Susan Zimmerman Trevor Kimbler Sheryl Garrovillo Jesse Bahn Lei Huang Zhongdong H. Michael Shepard Sanna Rosengren Christopher D. Thanos and Daniel C. Maneval Halozyme Therapeutics, Inc., San Diego, CA, 92121, USA Formerly of Correspondence to: Zhao, email: czhao@halozyme.com Keywords: hyaluronan; breast cancer; xenograft; tumor microenvironment; CD44 Received: August 05, 2019 Accepted: October 19,...
Cytokine therapy is limited by undesirable off-target side effects as well terminal differentiation and exhaustion of chronically stimulated T cells. Here, we describe the signaling properties a potentially unique cytokine design, where cell surface binding are separated between 2 different families receptors. This fusion protein cytokine, called OMCPmutIL-2, bound with high affinity to cytotoxic lymphocyte-defining immunoreceptor NKG2D but signaled through common γ chain receptor. In...
Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which neuroinflammation increasingly recognized to play a critical function. While innate inflammation has been implicated AD, little known about the contribution of adaptive immune response. Here we performed mass cytometry peripheral blood mononuclear cells combined with unbiased discovery and machine learning techniques found immunologic signature AD characterized by increased numbers CD8+ T effector memory CD45RA+...
We study stripe formation in two-dimensional systems under directional quenching a phase-diffusion approximation including nonadiabatic boundary effects. find through simple traveling waves for all angles relative to the line using an analytic continuation procedure. also present comprehensive analytical asymptotic formulas limiting cases of small and large as well rates. Of particular interest is regime angle slow rate which described by glide motion dislocation along line. A delocalization...
There is currently no consensus in the literature concerning impact of aging on properties hyaluronan (HA) subcutaneous (SC) space. Recombinant human hyaluronidase PH20 (rHuPH20) facilitates SC administration injected therapeutics by depolymerizing HA, facilitating bulk fluid flow, dispersion and absorption. This study assessed intrinsic HA space thus ability rHuPH20 to enhance delivery co-administered therapeutics. Histologic evaluations levels degradation were performed skin samples from...