A5005595749- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Axon Guidance and Neuronal Signaling
- Pluripotent Stem Cells Research
- Single-cell and spatial transcriptomics
- Neuroendocrine regulation and behavior
- Mesenchymal stem cell research
- Radio Astronomy Observations and Technology
- Superconducting and THz Device Technology
- Abdominal Surgery and Complications
- Nerve injury and regeneration
- Biliary and Gastrointestinal Fistulas
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Apelin-related biomedical research
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
The Ohio State University
2018-2025
St. Michael's Hospital
2024-2025
Florida State University
2020-2024
Brain Injury Association of America
2019
Angeline Elizabeth Kirby Memorial Health Center
2018
Stanford University
2004-2016
University of California, Berkeley
2009-2016
Loughborough University
2010
Kavli Institute for Particle Astrophysics and Cosmology
2009
Duke University
2007-2008
The subjective experience of stress leads to reproductive dysfunction in many species, including rodents and humans. Stress effects on reproduction result from multilevel interactions between the hormonal response system, i.e., hypothalamic-pituitary-adrenal (HPA) axis, hypothalamic-pituitary-gonadal (HPG) axis. A novel negative regulator HPG axis known as gonadotropin-inhibitory hormone (GnIH) was recently discovered quail, orthologous neuropeptides RFamide-related peptides (RFRPs) have...
Stress is a potent modulator of the mammalian brain. The highly conserved stress hormone response influences many brain regions, particularly hippocampus, region important for memory function. effect acute on unique population adult neural stem/progenitor cells (NPCs) that resides in hippocampus unclear. We found increased hippocampal cell proliferation and astrocytic fibroblast growth factor 2 (FGF2) expression. occurred independent basolateral amygdala input was mimicked by treating...
Ethologically relevant behavioral testing is a critical component of any study that uses mouse models to the cognitive effects various physiological or pathological changes. The object location task (OLT) and novel recognition (NORT) are two effective tasks commonly used reveal function relative health specific brain regions involved in memory. While both these tests exploit inherent preference mice for novelty memory previously encountered objects, OLT primarily evaluates spatial learning,...
The adult hippocampus hosts a population of neural stem and progenitor cells (NSPCs) that proliferates throughout the mammalian life span. To date, new neurons derived from NSPCs have been primary measure their functional relevance. However, recent studies show undifferentiated may shape environment through secreted growth factors. Whether endogenous secrete functionally relevant factors remains unclear. We hippocampal surprisingly large quantities essential factor VEGF in vitro vivo. This...
Abstract Increased dietary intake of choline early in life improves performance adult rats on memory tasks and prevents their age‐related decline. Because neurogenesis the hippocampus also declines with age, we investigated whether prenatal availability affects hippocampal Sprague–Dawley modifies neurogenic response to environmental stimulation. On embryonic days (ED) 12–17, pregnant ate a choline‐supplemented (SUP‐5 g/kg), sufficient (SFF‐1.1 or choline‐free (DEF) semisynthetic diet. Adult...
The vasculature is a key component of adult brain neural stem cell (NSC) niches. In the mammalian hippocampus, NSCs reside in close contact with dense capillary network. How this niche maintained unclear. We recently found that hippocampal express VEGF, soluble factor chemoattractive properties for vascular endothelia. Here, we show global and NSC-specific VEGF loss led to dissociation their intermediate progenitor daughter cells from local vasculature. Surprisingly, though, no changes...
A 26-year-old man sustained significant traumatic thoracoabdominal injuries following a gunshot. After multiple laparotomies, small-bowel resections, and an extended left hemicolectomy with end-colostomy formation, he developed high-output enterocutaneous fistula (ECF) loss of colostomy output. Computed tomography imaging confirmed ECF from the ileum to anterior abdominal wall. There was also long ileal stricture distal fistula. Owing his complex surgical abdomen proximity flap,...
We describe the QUaD experiment, a millimeter-wavelength polarimeter designed to observe Cosmic Microwave Background (CMB) from site at South Pole. The experiment comprises 2.64 m Cassegrain telescope equipped with cryogenically cooled receiver containing an array of 62 polarization-sensitive bolometers. focal plane contains pixels two different frequency bands, 100 GHz and 150 GHz, angular resolutions 5 arcmin 3.5 arcmin, respectively. high resolution allows observation CMB temperature...
Biological pathways that significantly contribute to sporadic Alzheimer's disease are largely unknown and cannot be observed directly. Cognitive symptoms appear only decades after the molecular onset, further complicating analyses. As a consequence, research is often restricted late-stage post-mortem studies of brain tissue. However, process expected trigger numerous cellular signaling modulate local systemic environment, resulting changes in secreted molecules carry information about...
The mammalian hippocampus shows marked decline in function with aging across many species, including humans and laboratory rodent models. This frequently manifests memory impairments that occur even the absence of dementia pathology. In humans, a number factors correlate preserved hippocampal aging, such as exercise, cognitive stimulation social ties. While interventional studies animal models clearly indicate exercise lead to preservation, there is relatively little research on whether ties...
Inducible Cre recombinase facilitates temporal control of genetic recombination in numerous transgenic model systems, a feature which has made it popular tool for adult neurogenesis studies. One the most common forms inducible Cre, CreER<sup>T2</sup>, requires activation by selective estrogen receptor modulator tamoxifen (TAM) to initiate LoxP-flanked sequences. To date, studies deliver TAM via intraperitoneal injection. But introduction TAM-infused commercial chows recently expanded...
Multipotent neural stem cells (NSCs) are found in several isolated niches of the adult mammalian brain where they have unique potential to assist tissue repair. Modern transcriptomics offer high-throughput methods for identifying disease or injury associated gene expression signatures endogenous NSCs, but require adaptation accommodate rarity NSCs. Bulk RNA sequencing (RNAseq) NSCs requires pooling mice, which impedes application labor-intensive models. Alternatively, single cell RNAseq can...
Objective: Psychosocial factors are associated with increased morbidity and mortality in healthy clinical populations. Behavioral interventions needed to train the large number of people community setting who affected by stressors use coping skills that will reduce these risk factors. The aim current study was evaluate efficacy three forms delivery a standardized, behavioral intervention—the Williams LifeSkills program—designed levels psychosocial nonclinical Methods: One hundred ninety-six...