A5023449944- Spinal Hematomas and Complications
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Muscle Physiology and Disorders
- Case Reports on Hematomas
- RNA regulation and disease
- Spinal Dysraphism and Malformations
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Autoimmune Neurological Disorders and Treatments
- Bat Biology and Ecology Studies
- Hedgehog Signaling Pathway Studies
- Amino Acid Enzymes and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Innovations in Medical Education
- Medical Malpractice and Liability Issues
- Immunotherapy and Immune Responses
- Developmental Biology and Gene Regulation
- Spaceflight effects on biology
- Folate and B Vitamins Research
- Ocular Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Spinal Cord Injury Research
Neurology, Inc
2025
Children's National
2024
University of Iowa
2014-2023
Howard Hughes Medical Institute
2023
Kurdistan University of Medical Sciences
2021
University of Iowa Hospitals and Clinics
2017
Congenital muscular dystrophy type 1A (MDC1A) is caused by recessive variants in laminin α2 (LAMA2). Patients have been found to white matter signal abnormalities on magnetic resonance imaging (MRI) but rarely structural brain abnormalities. We describe the autopsy neuropathology a 17-year-old with MRI. Dystrophic pathology was observed skeletal muscle, and sural nerve manifested mild degree of segmental demyelination remyelination. A diffuse, bilateral cobblestone appearance, numerous...
Physicians often exclude patients with a model for end‐stage liver disease (MELD) score ≥ 18 from transjugular intrahepatic portosystemic shunt (TIPS) procedure due to the concern higher risk of death. We aimed determine if TIPS increased death in these patients. analyzed interaction between and MELD 106 79 intractable ascites without TIPS. performed Cox proportional hazard regression, including both as time‐dependent covariates together their interaction, calculate impact on associated high...
Sonic hedgehog (Shh) signaling plays a major role in vertebrate development, from regulation of proliferation to the patterning various organs. In amniotes, Shh affects dorsoventral inner ear but anteroposterior teleost ears. It remains unknown how altered function relates morphogenetic changes that coincide with evolution limbs and novel auditory organs ear. this study, we used tetrapod, Xenopus laevis, test increasing concentrations signal pathway antagonist, Vismodegib, development....
Matriglycan (-1,3-β-glucuronic acid-1,3-α-xylose-) is a polysaccharide that synthesized on α-dystroglycan, where it functions as high-affinity glycan receptor for extracellular proteins, such laminin, perlecan and agrin, thus anchoring the plasma membrane to matrix. This biological activity closely associated with size of matriglycan. Using high-resolution mass spectrometry site-specific mutant mice, we show first time matriglycan T317/T319 T379 sites α-dystroglycan are not identical....
Prolonged space flight, specifically microgravity, presents a problem for exploration. Animal models with altered connections of the vestibular ear, and thus gravity sensation, would allow examination effects microgravity how various countermeasures can establish normal function. We describe an experimental apparatus to monitor ear manipulations generate asymmetric input on tadpole escape response. To perform movement pattern analysis, imaging was developed that uses high‐speed camera obtain...
We describe a case of quadriplegia from diffuse spinal cord infarction following unregulated cannabis inhalation.
Pseudo-TORCH Syndrome (PTS) encompasses a heterogeneous group of genetic disorders that may clinically and radiologically resemble congenital TORCH infections. These mimickers present with overlapping features manifested as intracranial systemic abnormalities. Collagen type IV alpha 1 chain (COL4A1)-related diseases, characterized by autosomal dominant inheritance, exhibit diverse phenotypic spectrum involving cerebrovascular, renal, ophthalmological, cardiac, muscular Cerebrovascular...
Purpose: Both MELD ≥18 and a need for transjugular intrahepatic portosystemic shunt (TIPS) placement identify patients at increased mortality risk. We evaluated if risk is independently by the of TIPS, in with both high TIPS. Materials Methods: Retrospective single center study receiving an elective TIPS refractory ascites, between 1999 2011. Study Group: 88 ascites who underwent Control group: 109 matched controls did not have Cox multivariable analysis adjusting etiology, age score,...