A5063154019- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Hemispheric Asymmetry in Neuroscience
- Language Development and Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Face Recognition and Perception
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Cerebral Palsy and Movement Disorders
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Attention Deficit Hyperactivity Disorder
- Child and Animal Learning Development
- Amino Acid Enzymes and Metabolism
- Bacterial Infections and Vaccines
- Reading and Literacy Development
- Cytomegalovirus and herpesvirus research
George Washington University
2013-2025
George Washington University Hospital
2022-2025
Children's National
2015-2025
National Hospital
2024-2025
National Institutes of Health
2017-2024
Jefferson Hospital for Neuroscience
2022-2024
Boston Children's Hospital
2021-2023
University of Virginia Health System
2023
University of Colorado Denver
2023
Children's Hospital Colorado
2023
Longitudinal research into adult outcomes in autism remains limited. Unlike previous longitudinal examinations of outcome autism, the twenty participants this study were evaluated across multiple assessments between early childhood (M = 3.9 years) and adulthood 26.6 years). In childhood, responsiveness to joint attention (RJA), language, intelligence assessed. adulthood, parents responded interviews assessing adaptive functioning, autistic symptomology global functioning their children. RJA...
Objective Functional magnetic resonance imaging is sensitive to the variation in language network patterns. Large populations are needed rigorously assess atypical patterns, which, even neurological populations, a minority. Methods We studied 220 patients with focal epilepsy and 118 healthy volunteers who performed an auditory description decision task. compared data‐driven hierarchical clustering approach commonly used priori laterality index (LI) threshold (LI < 0.20 as atypical)...
Abstract Infants gradually learn to share attention, but it is unknown how they acquire skills such as gaze‐following. Deák and Triesch ( ) suggest that gaze‐following could be acquired if infants adults' gaze direction likely aligned with interesting sights. This hypothesis stipulates adults tend look at things find interesting, by noticing this tendency. We tested the plausibility of through video‐based micro‐behavioral analysis naturalistic parent–infant play. The results revealed 3‐...
Individuals with Autism Spectrum Disorders (ASD) typically show impaired eye contact during social interactions. From a young age, they look less at faces than developing (TD) children and tend to avoid direct gaze. However, the reason for this behavior remains controversial; ASD might because perceive eyes as aversive or do not find engagement through mutual gaze rewarding.We monitored pupillary diameter measure of autonomic response in (n = 20, mean age 12.4) TD controls 18, 13.7) while...
Presurgical language assessment can help minimize damage to eloquent cortex during resective epilepsy surgery. Two methods for presurgical mapping are functional MRI (fMRI) and direct cortical stimulation (DCS) of implanted subdural electrodes. We compared fMRI results DCS optimize noninvasive localization assess its validity.
Abnormal eye contact is a core symptom of autism spectrum disorders (ASD), though little understood the neural bases gaze processing in ASD. Competing hypotheses suggest that individuals with ASD avoid due to anxiety-provoking nature direct or eye-gaze cues hold less interest significance children The current study examined effects direction on emotional faces typically developing (TD) and those While undergoing functional magnetic resonance imaging (fMRI), 16 high-functioning adolescents TD...
Summary Objective Children with epilepsy ( EPI ) have a higher rate of attention‐deficit/hyperactivity disorder ADHD ; 28–70%) than typically developing TD children (5–10%); however, attention is multidimensional. Thus, we aimed to characterize the profile difficulties in epilepsy. Methods Seventy‐five localization‐related ages 6–16 years and 75 age‐matched controls were evaluated using multimodal, multidimensional measures including direct performance parent ratings as well intelligence...
<h3>Objectives</h3> How brain MRI lesions associate with outcomes in pediatric anti-NMDA receptor encephalitis (pNMDARE) is unknown. In this study, we correlate T2-hyperintense clinical pNMDARE. <h3>Methods</h3> This was a multicenter retrospective cohort study from 11 institutions. Children younger than 18 years pNMDARE were included. One-year assessed by the modified Rankin Score (mRS) good (mRS ≤2) and poor ≥3) outcomes. <h3>Results</h3> A total of 175 subjects included, 1-year mRS...
Summary Objective Functional magnetic resonance imaging ( fMRI ) activation of the mesial temporal lobe MTL may be important for epilepsy surgical planning. We examined and lateralization during language in children adults with focal epilepsy. Methods One hundred forty‐two controls patients left hemisphere (pediatric: epilepsy, n = 17, mean age 9.9 ± 2.0; controls, 48; 9.1 2.6; adult: 20, 26.7 5.8; 57, 26.2 7.5) underwent 3T using a task (auditory description decision task). Image processing...
To demonstrate an association between magnetic resonance imaging (MRI) findings and pathologic characteristics in children who had surgery for medically refractory epilepsy due to focal cortical dysplasia (FCD).We retrospectively studied 110 surgery. Twenty-seven patients with FCD were included. Thirteen temporal lobe (TLE) 14 extra-temporal (ETLE). Three associated mesial sclerosis. Preoperative 3T MRIs interleaved nine controls blindly re-reviewed categorized according signal alteration....
Improve data-driven research to inform clinical decision-making with pediatric epilepsy surgery patients by expanding the Pediatric Epilepsy Research Consortium Surgery (PERC-Surgery) Workgroup include neuropsychological data. This article reports on process and initial success of this effort characterizes cognitive functioning largest multi-site cohort in United States.Pediatric neuropsychologists from 18 institutions completed surveys regarding practice impact involvement collaborative....
Children with focal epilepsy are at increased risk of language impairment, yet the neural substrate this dysfunction is not known. Using functional magnetic resonance imaging we investigated impact on developing system using measures network topology (spatial organization activation) and synchrony (functional connectivity). We studied healthy children (n = 48, 4–12 years, 24 females) 21, 5–12 nine left hemisphere dominance. Participants performed an age-adjusted auditory description decision...
Summary Objective We aimed to predict language deficits after epilepsy surgery. In addition evaluating surgical factors examined previously, we determined the impact of extent functional magnetic resonance imaging (fMRI) activation that was resected on naming ability. Method Thirty‐five adults (mean age 37.5 ± 10.9 years, 13 male) with temporal lobe completed a preoperative fMRI auditory description decision task, which reliably activates frontal and networks. Patients underwent resections...
The purpose of this study was to evaluate if focal cortical dysplasia (FCD) co-localization functional networks is associated with the temporal distribution epilepsy onset in FCD.International (20 center), retrospective cohort from Multi-Centre Epilepsy Lesion Detection (MELD) project. Patients included >3 years old, had 3D pre-operative T1 magnetic resonance imaging (MRI; 1.5 or 3 T) radiologic histopathologic FCD after surgery. Images processed using MELD protocol, masked...
In the presence of neurological insult, how language and memory networks jointly reorganise provides insights into mechanisms neuroplasticity can inform presurgical planning. As (re)organisation is often studied within a single cognitive modality, interact during in response to epilepsy implications for outcomes less clear. We investigated (1) rates patterns joint (2) their associations with pre- postsurgical function. Individuals (n=162) from three neurosurgical centres underwent Wada...
Evidence to guide the critical care management of children with ruptured brain arteriovenous malformations is lacking. We aimed determine whether there are associations between physiologic parameters and outcome in malformations. performed a single-center retrospective review patients ≤18 years age malformation from 2011 2023. Categorization was based on Pediatric Stroke Outcome Measure. Descriptive statistics were used. Most an rupture had poor at discharge (31/49, 63%) follow-up 3-12...
Abstract Objective To identify predictors of language lateralization derived from functional magnetic resonance imaging (fMRI) in children and adults with left‐ right‐sided focal epilepsy. Methods We conducted a mega‐analysis data 914 individuals 24 samples. used multilevel models to left right hemisphere epilepsy groups. assigned each participant clinical predictor score explore whether there was cumulative influence on increasing atypical lateralization. Results Left greater the combined...
Summary Objective Learning and memory are essential for academic success everyday functioning, but the pattern of skills its relationship to executive functioning in children with focal epilepsy is not fully delineated. We address a gap literature by examining between pediatric population. Methods Seventy 70 typically developing matched on age, intellectual gender underwent neuropsychological assessment, including measures intelligence (Wechsler Abbreviated Scale Intelligence [ WASI...
Summary Objective To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared direct cortical stimulation (DCS) in epilepsy surgery patients. Methods In this prospective case series, 17 patients with drug‐resistant had intracranial monitoring and resection from 2012 2016 1‐year follow‐up. All completed preoperative fMRI, mapping DCS subdural electrodes, pre‐ neuropsychological testing for function, resection. Changes function before after were assessed....